USP13 binds UFD1L:SKP2

Stable Identifier
R-HSA-6781922
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In the nucleus USP13 binds UFD1 which acts as a scaffold connecting USP13 to SKP2. USP13 mediates the deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD) by counteracting APC/C(Cdh1)-mediated SKP2 ubiquitination (Chen et al. 2011).
Literature References
PubMed ID Title Journal Year
21571647 Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control

Gutierrez, GJ, Ronai, ZA, Chen, M

Proc. Natl. Acad. Sci. U.S.A. 2011
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!