Reactome | ZRANB1 [cytosol]

ZRANB1 [cytosol]

Stable Identifier

R-HSA-6781939

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitin thioesterase ZRANB1, ZRAN1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P13010 XRCC5

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External Reference Information

External Reference

UniProt:Q9UGI0 ZRANB1

Gene Names

ZRANB1, TRABID

Chain

chain:1-708

Reference Genes

BioGPS Gene:54764 ZRANB1

COSMIC (genes):ZRANB1 ZRANB1

CTD Gene:54764 ZRANB1

dbSNP Gene:54764 ZRANB1

ENSEMBL:ENSG00000019995 ZRANB1

ENSEMBL_homo_sapiens_GENE:ENSG00000019995.6 ZRANB1

HGNC:18224 ZRANB1

KEGG Gene (Homo sapiens):54764 ZRANB1

Monarch:54764 ZRANB1

NCBI Gene:54764 ZRANB1

OMIM:611749 ZRANB1

UCSC:Q9UGI0 ZRANB1

Reference Transcript

Other Identifiers

11727497_x_at

11727498_at

11727499_s_at

11758596_s_at

11758984_at

16710360

225130_PM_at

225130_at

225131_PM_at

225131_at

225138_PM_at

225138_at

3269341

3269342

3269343

3269344

3269355

3269358

3269359

3269361

3269366

3269368

3269369

3269376

3269377

3269378

3269379

3269380

3269381

3269382

3269383

3269385

3269387

3370743

43473_at

49688_at

54764

61267_at

65838_s_at

7931226

83098_at

A_14_P105497

A_14_P117940

A_24_P389714

A_24_P9809

A_33_P3261565

GE55302

GO:0003824

GO:0004843

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006508

GO:0007010

GO:0008233

GO:0008234

GO:0016055

GO:0016477

GO:0016787

GO:0022604

GO:0023052

GO:0030163

GO:0030177

GO:0031593

GO:0035523

GO:0036211

GO:0043226

GO:0043231

GO:0046872

GO:0048856

GO:0048870

GO:0070530

GO:0070536

GO:0071947

GO:0101005

GO:0140096

GO:1990168

HMNXSV003009721

Hs.26320.0.S1_3p_at

Hs.26320.0.S2_3p_at

Hs.26320.0.S3_3p_at

ILMN_1757742

PH_hs_0002321

TC10000909.hg

p33382

Participates

as a member of

OTUD7B,TNFAIP3,ZRANB1 [cytosol] (Homo sapiens)

as a component of

ZRANB1:K63polyUb-APC [cytosol] (Homo sapiens)

as an input of

ZRANB1 binds APC (Homo sapiens)

Inferred To

trbd [cytosol] (Drosophila melanogaster)

ZRANB1 [cytosol] (Bos taurus)

ZRANB1 [cytosol] (Canis familiaris)

ZRANB1 [cytosol] (Danio rerio)

ZRANB1 [cytosol] (Gallus gallus)

ZRANB1 [cytosol] (Mus musculus)

ZRANB1 [cytosol] (Sus scrofa)

ZRANB1 [cytosol] (Xenopus tropicalis)

Zranb1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_060050.2, XP_016871846.1, XP_005269983.1

OpenTargets

ENSG00000019995

HPA

ENSG00000019995-ZRANB1

GeneCards

Q9UGI0

Ensembl

ENST00000359653, ENSP00000352676, ENSG00000019995

PRO

Q9UGI0

Pharos - Targets

Q9UGI0

PDB

5AF6, 3ZRH

Interactors (144)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30039 PBLD			0.756	6
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.675	4
UniProt:P53582 METAP1	1	METAP1 [cytosol] (R-HSA-2534097)	0.601	4
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.558	2
UniProt:Q15287 RNPS1	2	RNPS1 [nucleoplasm] (R-HSA-156778) RNPS1 [cytosol] (R-HSA-159256)	0.556	3
UniProt:P13010 XRCC5	4	XRCC5 [extracellular region] (R-HSA-6806530) XRCC5 [secretory granule lumen] (R-HSA-6801297) XRCC5 [cytosol] (R-HSA-3134849) XRCC5 [nucleoplasm] (R-HSA-58274)	0.556	3
UniProt:Q15560 TCEA2			0.556	3
UniProt:Q9Y2I9-2 Q9Y2I92			0.556	3
UniProt:Q3KQV3 ZNF792	1	ZNF792 [nucleoplasm] (R-HSA-3110242)	0.556	3
UniProt:P57075-2 UBASH3A			0.556	3
UniProt:Q9BSW7 SYT17			0.556	3
UniProt:Q8IVT4 Q8IVT4			0.556	3
UniProt:Q96C24 SYTL4	2	SYTL4 [platelet alpha granule membrane] (R-HSA-8862959) SYTL4 [plasma membrane] (R-HSA-8862971)	0.556	3
UniProt:O75564-2 O755642			0.556	3
IntAct:EBI-22335676 CCSB ORF ID			0.556	3
UniProt:Q6ZNH5 ZN497			0.556	3
UniProt:Q9UK58 CCNL1			0.556	3
UniProt:Q86XF7 ZN575			0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:P61326 MAGOH	1	MAGOH [nucleoplasm] (R-HSA-156658)	0.556	3
UniProt:Q9H0I2 ENKD1			0.556	3
UniProt:O95696 BRD1	1	BRD1 [nucleoplasm] (R-HSA-3318450)	0.556	3
UniProt:Q9BVV2 FND11			0.556	3
UniProt:Q96EG3 ZN837			0.556	3
UniProt:Q14119 VEZF1			0.556	3
UniProt:Q9HC52 CBX8	1	CBX8 [nucleoplasm] (R-HSA-389117)	0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q96BZ8 LENG1	1	LENG1 [nucleoplasm] (R-HSA-9769590)	0.556	3
UniProt:Q9BZE0 GLIS2			0.556	3
UniProt:O43189 PHF1	1	PHF1 [nucleoplasm] (R-HSA-5084105)	0.556	3
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.556	3
UniProt:Q6NYC8 PPR18			0.556	3
UniProt:P59910 DJB13			0.556	3
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.556	3
UniProt:Q9UFB7 ZBT47			0.556	3
UniProt:Q8NE01 CNNM3			0.556	3
UniProt:O15371 EIF3D	1	EIF3D [cytosol] (R-HSA-72548)	0.556	3
UniProt:P19544-6 WT1			0.556	3
UniProt:Q9NVQ4-2 FAIM			0.556	3
UniProt:B7ZLI8 B7ZLI8			0.556	3
UniProt:Q07002 CDK18			0.556	3
UniProt:Q96B67 ARRD3			0.556	3
UniProt:P0DI81-3 TRAPPC2			0.556	3
UniProt:Q8N8B7-2 TCEANC			0.556	3
UniProt:Q9BRJ7 TIRR			0.556	3
UniProt:Q8TAP4-4 LMO3			0.556	3
UniProt:Q96HB5 CC120			0.556	3
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.556	3
UniProt:Q96SQ5 ZNF587	1	ZNF587 [nucleoplasm] (R-HSA-2127565)	0.556	3
UniProt:P09067 HXB5			0.556	3
UniProt:O15442-2 MPPED1			0.556	3
UniProt:Q9UBL6-2 CPNE7			0.556	3
UniProt:O60941-5 DTNB			0.556	3
UniProt:Q9BUZ4 TRAF4			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:O15481 MAGB4			0.556	3
UniProt:P50548 ERF	3	p-T526-ERF [nucleoplasm] (R-HSA-3209166) p-T526-ERF [cytosol] (R-HSA-3209167) ERF [nucleoplasm] (R-HSA-2534321)	0.556	3
UniProt:O43809 NUDT21	1	NUDT21 [nucleoplasm] (R-HSA-72010)	0.556	3
UniProt:Q3SY00 T10IP			0.556	3
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.556	3
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.556	3
UniProt:P15622-3 ZNF250			0.556	3
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.556	3
UniProt:Q8NHY3 GA2L2			0.556	3
UniProt:Q9UII6 DS13B			0.556	3
UniProt:X5D778 X5D778			0.556	3
UniProt:Q96PC2 IP6K3	1	IP6K3 [cytosol] (R-HSA-1604594)	0.556	3
UniProt:Q16512 PKN1	3	p-T774-PKN1 [nucleoplasm] (R-HSA-5625721) p-T774-PKN1 [cytosol] (R-HSA-5623651) PKN1 [cytosol] (R-HSA-5623613)	0.556	3
UniProt:Q8IYE1 CCD13			0.556	3
UniProt:Q3B820 F161A			0.556	3
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.556	3
UniProt:Q8TAE8 GADD45GIP1	1	GADD45GIP1 [mitochondrial matrix] (R-HSA-5368253)	0.556	3
UniProt:Q99633 PRPF18	1	PRPF18 [nucleoplasm] (R-HSA-5688093)	0.556	3
UniProt:Q96NL3 ZNF599	1	ZNF599 [nucleoplasm] (R-HSA-2127571)	0.556	3
UniProt:Q8WUT1 Q8WUT1			0.556	3
UniProt:Q5T6S3 PHF19	1	PHF19 [nucleoplasm] (R-HSA-5084115)	0.556	3
UniProt:Q9P2K5-2 MYEF2			0.556	3
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.556	3
UniProt:Q9P0T4 ZN581			0.556	3
UniProt:O75419 CDC45	1	CDC45 [nucleoplasm] (R-HSA-68563)	0.556	3
UniProt:Q9H707 ZNF552	1	ZNF552 [nucleoplasm] (R-HSA-1973877)	0.556	3
UniProt:Q9UJV3-2 MID2			0.556	3
UniProt:Q96H86 ZNF764	1	ZNF764 [nucleoplasm] (R-HSA-3343766)	0.556	3
UniProt:Q9H257-2 CARD9			0.556	3
UniProt:Q9Y247 FA50B			0.556	3
UniProt:Q9HC98-4 NEK6			0.556	3
UniProt:P17021 ZNF17	1	ZNF17 [nucleoplasm] (R-HSA-974984)	0.556	3
UniProt:Q6DHY5 TBC3G			0.556	6
UniProt:Q8WWY3 PRPF31	1	PRPF31 [nucleoplasm] (R-HSA-6806772)	0.556	3
UniProt:Q8TBH0 ARRD2			0.556	3
UniProt:O95931 CBX7			0.556	3
UniProt:Q9BU76 MMTAG2	3	MMTAG2 [secretory granule lumen] (R-HSA-6801073) MMTAG2 [extracellular region] (R-HSA-6806452) MMTAG2 [ficolin-1-rich granule lumen] (R-HSA-6801074)	0.556	3
UniProt:Q9BT49 THAP7			0.556	3
UniProt:Q5T619 ZN648			0.556	3
UniProt:Q9UEG4 ZN629			0.556	3
UniProt:Q494U1-3 PLEKHN1			0.556	3
UniProt:Q96BV0 ZNF775	1	ZNF775 [nucleoplasm] (R-HSA-3110230)	0.556	3
UniProt:Q9ULM2 ZNF490	1	ZNF490 [nucleoplasm] (R-HSA-1247870)	0.556	3
UniProt:P0DTD1-PRO_0000449633 REP			0.556	3
UniProt:Q12774 ARHGEF5	1	ARHGEF5 [cytosol] (R-HSA-8873909)	0.556	3
UniProt:Q9UJ04 TSYL4			0.556	3
UniProt:Q8WXF1-2 PSPC1			0.556	3
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.556	3
UniProt:Q9C086 INO80B	1	INO80B [nucleoplasm] (R-HSA-5689599)	0.556	3
UniProt:Q5T7W7 TSTD2			0.556	3
UniProt:Q96FJ0 STAMBPL1	1	STAMBPL1 [cytosol] (R-HSA-6783264)	0.556	3
UniProt:A6NER0 TBC3F			0.556	3
UniProt:Q96PV4 PNMA5			0.556	3
UniProt:Q8TBE0 BAHD1			0.556	3
UniProt:O94955 RHOBTB3	1	RHOBTB3 [trans-Golgi network membrane] (R-HSA-6813908)	0.556	3
UniProt:Q8NA54 IQUB			0.556	3
UniProt:Q9Y228 T3JAM			0.556	3
UniProt:O43602-2 DCX			0.556	3
UniProt:Q15973 ZNF124	1	ZNF124 [nucleoplasm] (R-HSA-975017)	0.556	3
UniProt:Q9H5Z6-2 FAM124B			0.556	3
UniProt:Q14005-2 Q140052			0.556	3
UniProt:Q8N715 CC185			0.556	3
UniProt:O43395 PRPF3	1	PRPF3 [nucleoplasm] (R-HSA-6806806)	0.556	3
UniProt:P35590 TIE1			0.556	3
UniProt:P31273 HOXC8	1	HOXC8 [nucleoplasm] (R-HSA-3222311)	0.556	3
UniProt:P55081 MFAP1	1	MFAP1 [nucleoplasm] (R-HSA-2396419)	0.556	3
UniProt:Q63ZY3 KANK2			0.556	3
UniProt:O95872 GPAN1			0.556	3
UniProt:O15160 POLR1C	2	POLR1C [nucleoplasm] (R-HSA-63498) POLR1C [cytosol] (R-HSA-1964454)	0.556	3
UniProt:Q96MY7 F161B			0.556	3
UniProt:Q9UGP5-2 POLL			0.556	3
UniProt:Q9BXS5 AP1M1	7	AP1M1 [cytoplasmic vesicle membrane] (R-HSA-351196) AP1M1 [Golgi membrane] (R-HSA-350805) AP1M1 [lysosomal membrane] (R-HSA-432708) AP1M1 [trans-Golgi network membrane] (R-HSA-2130512) AP1M1 [cytosol] (R-HSA-167700) AP1M1 [plasma membrane] (R-HSA-6806311) AP1M1 [specific granule membrane] (R-HSA-6799365)	0.556	3
UniProt:Q8IVW4 CDKL3			0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:O95363 FARS2	1	FARS2(1-?) [mitochondrial matrix] (R-HSA-379565)	0.556	3
UniProt:Q9UKW4 VAV3	2	VAV3 [cytosol] (R-HSA-430152) p-Y173-VAV3 [cytosol] (R-HSA-442287)	0.556	3
UniProt:Q9H0E2 TOLLIP	4	TOLLIP [cytosol] (R-HSA-446885) TOLLIP [azurophil granule lumen] (R-HSA-6799709) TOLLIP [extracellular region] (R-HSA-6800448) TOLLIP [specific granule lumen] (R-HSA-6799719)	0.556	3
UniProt:Q8WXB1 METTL21A	1	METTL21A [nucleoplasm] (R-HSA-8876682)	0.556	3
UniProt:Q9HAQ2 KIF9	1	KIF9 [cytosol] (R-HSA-984616)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	3
UniProt:Q7L5A3 ATOSB			0.556	3
UniProt:Q7Z4V0 ZN438			0.556	3
UniProt:O43167 ZBT24			0.556	3
UniProt:Q8IZW8 TNS4	1	TNS4 [cytosol] (R-HSA-201624)	0.556	3
UniProt:Q9H9D4 ZN408			0.556	3
UniProt:Q8TAU3 ZNF417	1	ZNF417 [nucleoplasm] (R-HSA-1247539)	0.556	3
UniProt:Q86YV0 RASAL3	1	RASAL3 [cytosol] (R-HSA-5658226)	0.556	3
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.556	3
UniProt:Q96IQ9 ZN414			0.527	2

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