Reactome | Gap-filling DNA repair synthesis and ligation in TC-NER

Gap-filling DNA repair synthesis and ligation in TC-NER

Stable Identifier

R-HSA-6782210

Type

Pathway

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Gap-filling DNA repair synthesis and ligation in TC-NER

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In transcription-coupled nucleotide excision repair (TC-NER), similar to global genome nucleotide excision repair (GG-NER), DNA polymerases delta or epsilon, or the Y family DNA polymerase kappa, fill in the single stranded gap that remains after dual incision. DNA ligases LIG1 or LIG3, subsequently seal the single stranded nick by ligating the 3' end of the newly synthesized patch with the 5' end of incised DNA (Staresincic et al. 2009, Ogi et al. 2010, Arakawa et al. 2012, Paul-Konietzko et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
20227374	Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells Limsirichaikul, S, Takenaka, K, Yamashita, S, Cloney, R, Lehmann, AR, Miki, Y, Mullenders, LH, Ogi, T, Overmeer, RM, Fousteri, M, Niimi, A, Jaspers, NG, Volker, M, Nakazawa, Y	Mol. Cell	2010
26131740	DNA Ligases I and III Support Nucleotide Excision Repair in DT40 Cells with Similar Efficiency Arakawa, H, Paul-Konietzko, K, Iliakis, G, Thomale, J	Photochem Photobiol	2015
22127868	Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells Arakawa, H, Bednar, T, Wang, M, Mladenov, E, Bencsik-Theilen, AA, Iliakis, G, Paul, K	Nucleic Acids Res	2012
19279666	Coordination of dual incision and repair synthesis in human nucleotide excision repair Wijgers, N, Staresincic, L, Schärer, OD, Gourdin, AM, Fagbemi, AF, Enzlin, JH, Dunand-Sauthier, I, Clarkson, SG, Giglia-Mari, G, Vermeulen, W	EMBO J.	2009