ADAT1 deaminates adenosine-37 in tRNA(Ala)

Stable Identifier
R-HSA-6782336
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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ADAT1 deaminates adenosine-37 in tRNA(Ala)
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ADAT1 deaminates adenosine-37 of tRNA(Ala) yielding inosine-37, which may then be methylated to N1-methylinosine-37 (Maas et al. 1999). The homologue in Saccharomyces, Tad1p, catalyzes the same reaction, indicating the deamination of adenosine-37 is highly conserved in eukaryotes.
Literature References
PubMed ID Title Journal Year
10430867 Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes

Gerber, AP, Maas, S, Rich, A

Proc. Natl. Acad. Sci. U.S.A. 1999
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Output
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Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

tRNA-specific adenosine deaminase activity of ADAT1 [nucleoplasm]

Physical Entity
ADAT1 [nucleoplasm] (Homo sapiens)
Activity
tRNA-specific adenosine deaminase activity (GO:0008251)
Inferred From
TAD1 deaminates adenosine-37 in tRNA(Ala) yielding inosine-37 (Saccharomyces cerevisiae)
Authored
May, B  (2015-05-30)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-06-06)
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