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Ub-KEAP1 [cytosol]
Stable Identifier
R-HSA-6782766
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
KEAP1, Kelch-like ECH-associated protein 1, KEAP1_HUMAN, KLHL19, KIAA0132
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Homo sapiens)
USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Homo sapiens)
Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Homo sapiens)
Ub-KEAP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14145 KEAP1
Gene Names
KEAP1, INRF2, KIAA0132, KLHL19
Chain
chain:1-624
Reference Genes
BioGPS Gene:9817 KEAP1
COSMIC (genes):KEAP1 KEAP1
CTD Gene:9817 KEAP1
dbSNP Gene:9817 KEAP1
ENSEMBL:ENSG00000079999 KEAP1
ENSEMBL_homo_sapiens_GENE:ENSG00000079999.14 KEAP1
HGNC:23177 KEAP1
KEGG Gene (Homo sapiens):9817 KEAP1
Monarch:9817 KEAP1
NCBI Gene:9817 KEAP1
OMIM:606016 KEAP1
UCSC:Q14145 KEAP1
Reference Transcript
RefSeq:XM_005260174.1 KEAP1
RefSeq:NM_012289.3 KEAP1
RefSeq:XM_005260173.1 KEAP1
RefSeq:XM_011528452.1 KEAP1
RefSeq:NM_203500.1 KEAP1
Other Identifiers
11716444_a_at
16868743
202417_PM_at
202417_at
35322_at
3850364
3850365
3850366
3850367
3850369
3850370
3850371
3850372
3850373
3850374
3850376
3850377
3850378
3850379
3850381
8034034
9817
A_23_P119141
D50922_at
GE57257
GO:0001701
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005783
GO:0005815
GO:0005829
GO:0005856
GO:0005884
GO:0006351
GO:0006355
GO:0006511
GO:0006914
GO:0008152
GO:0010506
GO:0016234
GO:0016567
GO:0030154
GO:0030163
GO:0030496
GO:0031463
GO:0032436
GO:0032991
GO:0034451
GO:0034599
GO:0036211
GO:0042802
GO:0043226
GO:0043433
GO:0045604
GO:0048856
GO:0060090
GO:0061629
GO:0070887
GO:0071353
GO:0097718
GO:1990756
HMNXSV003035494
ILMN_1711787
ILMN_2410771
ILMN_2410772
PH_hs_0003698
TC19001166.hg
g6912451_3p_at
Participates
as a member of
Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Homo sapiens)
Other forms of this molecule
ub-KEAP1 [cytosol]
KEAP1 [cytosol]
Inferred To
Keap1 [cytosol]
(Drosophila melanogaster)
Keap1 [cytosol]
(Mus musculus)
Keap1 [cytosol]
(Rattus norvegicus)
KEAP1 [cytosol]
(Bos taurus)
KEAP1 [cytosol]
(Canis familiaris)
KEAP1 [cytosol]
(Sus scrofa)
keap1b [cytosol]
(Danio rerio)
Modified Residues
Name
ubiquitinylated lysine (polyubiquitin chain [cytosol]) at unknown position
Modification
polyubiquitin chain [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_005260231.1
,
XP_011526754.1
,
XP_005260230.1
,
NP_036421.2
,
NP_987096.1
Guide to Pharmacology - Targets
2757
OpenTargets
ENSG00000079999
ZINC - Substances
KEAP1_HUMAN
HPA
ENSG00000079999-KEAP1
GeneCards
Q14145
ZINC target
Q14145
Ensembl
ENST00000393623
,
ENST00000171111
,
ENSP00000171111
,
ENSP00000377245
,
ENSG00000079999
PRO
Q14145
Pharos - Targets
Q14145
ZINC - Predictions - Purchasable
KEAP1_HUMAN
PDB
6LRZ
,
2FLU
,
8EHV
,
7Q6Q
,
5WFV
,
8IVG
,
8EJR
,
7K2Q
,
5WFL
,
7X4X
,
4L7B
,
7K2E
,
4L7C
,
7XM5
,
5GIT
,
5WIY
,
7K2P
,
4IFN
,
5F72
,
7K2D
,
8X34
,
7K2M
,
7Q5H
,
3VNH
,
1U6D
,
7K2A
,
8PKW
,
7K2L
,
7XM2
,
4CXT
,
8IXS
,
8PKV
,
7K2I
,
6TYM
,
4L7D
,
5WHO
,
8WFG
,
7K29
,
6TYP
,
7K2H
,
1ZGK
,
4IFL
,
7XM4
,
3VNG
,
7Q96
,
7XM3
,
5DAF
,
5NLB
,
6W68
,
6FMQ
,
6HWS
,
8IVR
,
8EJS
,
4IQK
,
6W69
,
7Q6S
,
5WHL
,
6FMP
,
7K2R
,
4CXI
,
6WCQ
,
7K2S
,
4N1B
,
4CXJ
,
5X54
,
7X4W
,
6SP4
,
6T7Z
,
7K2N
,
7EXI
,
6V6Z
,
6UF0
,
7K2O
,
6ROG
,
8PKX
,
6FFM
,
7K2C
,
4IFJ
,
7K2B
,
7K2J
,
7XOT
,
6T7V
,
7K2K
,
5WG1
,
7K28
,
4XMB
,
6W67
,
6W66
,
7K2F
,
7K2G
,
6SP1
,
6Z6A
,
6TG8
,
4IN4
,
3ZGC
,
5DAD
,
3ZGD
,
8PKU
,
7Q8R
Interactors (77)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16236 NFE2L2
13
p-S,T,S558-NFE2L2 [nucleoplasm]
(R-HSA-9795736)
p-S40, S344, S347- NFE2L2 [nucleoplasm]
(R-HSA-9762050)
p-S344, S347,T-NFE2L2 [nucleoplasm]
(R-HSA-9762048)
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762058)
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762055)
ub-NFE2L2 [cytosol]
(R-HSA-9758077)
p-S40-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760018)
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760033)
NFE2L2 [cytosol]
(R-HSA-201566)
p-S,T-NFE2L2 [cytosol]
(R-HSA-8932311)
p-S40-NFE2L2 [cytosol]
(R-HSA-8932290)
p-S,T-NFE2L2 [nucleoplasm]
(R-HSA-9715110)
p-S40-NFE2L2 [nucleoplasm]
(R-HSA-9715109)
0.978
39
UniProt:Q13501 SQSTM1
7
SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711967)
SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711954)
K7 ub-SQSTM1 [cytosol]
(R-HSA-9759088)
p-S349 SQSTM1 [cytosol]
(R-HSA-9766524)
ub K420 p-S349 SQSTM1 [cytosol]
(R-HSA-9766536)
SQSTM1 [nucleoplasm]
(R-HSA-210961)
SQSTM1 [cytosol]
(R-HSA-193937)
0.967
21
UniProt:Q9NY33 DPP3
1
DPP3 [cytosol]
(R-HSA-9795741)
0.907
13
UniProt:Q13257 MAD2L1
2
MAD2L1 [cytosol]
(R-HSA-141400)
Activated MAD2L1 [cytosol]
(R-HSA-141447)
0.831
8
UniProt:P62495 ETF1
3
Me-Q185-ETF1 [cytosol]
(R-HSA-6800157)
4OHK63-ETF1 [cytosol]
(R-HSA-9629948)
ETF1 [cytosol]
(R-HSA-54433)
0.831
8
UniProt:Q86YC2 PALB2
20
PALB2 Y28C [nucleoplasm]
(R-HSA-9724169)
PALB2 L35P [nucleoplasm]
(R-HSA-9724168)
PALB2 L24S [nucleoplasm]
(R-HSA-9724172)
PALB2 L21A [nucleoplasm]
(R-HSA-9704339)
PALB2 R37H [nucleoplasm]
(R-HSA-9724178)
PALB2 L21F [nucleoplasm]
(R-HSA-9704347)
PALB2 E12* [nucleoplasm]
(R-HSA-9704349)
PALB2 R37C [nucleoplasm]
(R-HSA-9724188)
PALB2 L35F [nucleoplasm]
(R-HSA-9704338)
PALB2 L947F [nucleoplasm]
(R-HSA-9724554)
PALB2 G1043D [nucleoplasm]
(R-HSA-9724584)
PALB2 T1030I [nucleoplasm]
(R-HSA-9704424)
PALB2 T841Qfs*10 [nucleoplasm]
(R-HSA-9704749)
PALB2 L1119P [nucleoplasm]
(R-HSA-9724589)
PALB2 L947S [nucleoplasm]
(R-HSA-9724557)
PALB2 L1143P [nucleoplasm]
(R-HSA-9704428)
PALB2 L1070P [nucleoplasm]
(R-HSA-9724556)
PALB2 C77Vfs*100 [nucleoplasm]
(R-HSA-9704738)
PALB2 L939W [nucleoplasm]
(R-HSA-9704417)
PALB2 L961P [nucleoplasm]
(R-HSA-9724583)
0.8
6
UniProt:Q9BRX9 WDR83
1
WDR83 [endosome membrane]
(R-HSA-5672942)
0.781
7
UniProt:O95198 KLHL2
1
KLHL2 [cytosol]
(R-HSA-8863217)
0.77
7
UniProt:Q6P9E2 Q6P9E2
0.718
6
UniProt:Q96TA1 NIBA2
0.718
9
UniProt:P06454-2 PTMA
0.718
6
UniProt:Q6P1L5 F117B
0.718
6
UniProt:P54619 PRKAG1
2
PRKAG1 [nucleoplasm]
(R-HSA-2151202)
PRKAG1 [cytosol]
(R-HSA-380946)
0.718
6
UniProt:P62310 LSM3
2
LSM3 [nucleoplasm]
(R-HSA-6806807)
LSM3 [cytosol]
(R-HSA-429894)
0.718
6
UniProt:Q14494 NF2L1
0.704
28
UniProt:Q9Y3Q8 T22D4
0.687
4
UniProt:Q13618 CUL3
3
G76-NEDD8-K712-CUL3 [cytosol]
(R-HSA-8952516)
CUL3 [nucleoplasm]
(R-HSA-5635033)
CUL3 [cytosol]
(R-HSA-975979)
0.666
5
UniProt:P02724 GYPA
1
GYPA [plasma membrane]
(R-HSA-8867204)
0.666
4
UniProt:Q9NPC3 CIP1
0.666
4
UniProt:Q9UH77 KLHL3
1
KLHL3 [cytosol]
(R-HSA-8863198)
0.666
5
UniProt:O14525-2 ASTN1
0.618
4
UniProt:O14920 IKBKB
3
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
0.61
6
UniProt:P45381 ASPA
1
ASPA [cytosol]
(R-HSA-5691513)
0.601
4
UniProt:Q04206 RELA
7
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.592
4
UniProt:O95166 GABARAP
3
GABARAP [autophagosome membrane]
(R-HSA-5683634)
GABARAP(1-117) [cytosol]
(R-HSA-5682696)
GABARAP [cytosol]
(R-HSA-975521)
0.59
5
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:B8Q183 B8Q183
0.556
4
UniProt:Q9NX09 DDIT4
1
DDIT4 [cytosol]
(R-HSA-5632374)
0.556
3
UniProt:P68400 CSNK2A1
2
CSNK2A1 [nucleoplasm]
(R-HSA-6805057)
CSNK2A1 [cytosol]
(R-HSA-201713)
0.556
3
UniProt:P02458-1 COL2A1
0.556
3
UniProt:Q2NKX9 CB068
0.556
3
UniProt:P05107 ITGB2
4
ITGB2 [specific granule membrane]
(R-HSA-6803284)
ITGB2 [ficolin-1-rich granule membrane]
(R-HSA-6803310)
ITGB2 [tertiary granule membrane]
(R-HSA-6803342)
ITGB2 [plasma membrane]
(R-HSA-198010)
0.556
3
UniProt:A9UGY9 A9UGY9
0.556
3
UniProt:Q14440 Q14440
0.556
3
UniProt:P05362 ICAM1
1
ICAM1 [plasma membrane]
(R-HSA-197683)
0.556
3
UniProt:P58317 ZN121
0.556
3
UniProt:Q9BYX4 IFIH1
3
IFIH1 [cytosol]
(R-HSA-913536)
K48polyUb-IFIH1 [cytosol]
(R-HSA-3080557)
PolyUb-IFIH1 [cytosol]
(R-HSA-6782812)
0.556
3
UniProt:Q6P6B1 ERIC5
0.556
3
UniProt:Q9P202 WHRN
1
WHRN [cytosol]
(R-HSA-204726)
0.556
3
UniProt:Q96HA8 NTAQ1
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:Q9UGK3 STAP2
2
p-Y250-STAP2 [plasma membrane]
(R-HSA-8848079)
STAP2 [cytosol]
(R-HSA-8848028)
0.556
3
UniProt:O60336 MABP1
0.556
3
UniProt:Q9NX65 ZSCAN32
1
ZSCAN32 [nucleoplasm]
(R-HSA-1247547)
0.556
3
UniProt:A0A0C4DFT7 A0A0C4DFT7
0.556
3
UniProt:Q9BWT7 CAR10
0.556
3
UniProt:Q49AR9 Q49AR9
0.556
3
UniProt:Q8TDV0 GP151
0.556
3
UniProt:Q9UKX7 NUP50
1
NUP50 [nucleoplasm]
(R-HSA-157740)
0.556
3
UniProt:Q8N573-5 OXR1
0.556
3
UniProt:Q9NZJ9 NUDT4
1
NUDT4 [cytosol]
(R-HSA-1604676)
0.556
3
UniProt:Q9BTE3-2 MCMBP
0.556
3
UniProt:Q96GM5 SMARCD1
1
SMARCD1 [nucleoplasm]
(R-HSA-389255)
0.556
3
UniProt:P17709
7
HK3 [secretory granule lumen]
(R-SCE-6801511-3)
HK3 [extracellular region]
(R-SCE-6806457-3)
HK3 [ficolin-1-rich granule lumen]
(R-SCE-6801527-3)
GCK [nucleoplasm]
(R-SCE-450102-3)
HK3 [cytosol]
(R-SCE-70412-3)
GCK [cytosol]
(R-SCE-450094-3)
HK1 [cytosol]
(R-SCE-70395-3)
0.556
3
UniProt:P38109 ATG42
0.556
3
UniProt:Q4KMZ1 IQCC
0.556
3
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.556
3
UniProt:Q8N4I8 Q8N4I8
0.556
3
UniProt:Q96JC9 EAF1
1
EAF1 [nucleoplasm]
(R-HSA-8932787)
0.556
3
UniProt:Q9H1Y0 ATG5
3
ATG5 [phagocytic vesicle membrane]
(R-HSA-5205636)
GlyK130-ATG5 [cytosol]
(R-HSA-5683582)
ATG5 [cytosol]
(R-HSA-936010)
0.556
3
UniProt:Q9P0N9 TBC1D7
1
TBC1D7 [cytosol]
(R-HSA-8854154)
0.556
3
UniProt:P02452 COL1A1
20
3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023648)
3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023667)
GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023604)
GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022999)
3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023559)
3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023582)
COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1650777)
3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1985659)
3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022446)
3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022951)
3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022954)
5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1985663)
Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396137)
Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396440)
Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396471)
Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396464)
Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396068)
Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396388)
Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396315)
Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396441)
0.556
3
UniProt:Q15149 PLEC
3
PLEC(2396-4684) [cytosol]
(R-HSA-350618)
PLEC(1-2395) [cytosol]
(R-HSA-350638)
PLEC [cytosol]
(R-HSA-201575)
0.544
3
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [cytosol]
(R-HSA-5205651)
0.527
2
UniProt:P33151 CDH5
2
p-S665-VE-cadherin [plasma membrane]
(R-HSA-5357435)
VE-cadherin [plasma membrane]
(R-HSA-418992)
0.527
2
UniProt:Q8IVL6 P3H3
1
LEPREL2 [endoplasmic reticulum lumen]
(R-HSA-1650821)
0.527
2
UniProt:Q9BTE3 MCMBP
0.527
2
UniProt:Q86VM9 ZCH18
0.527
2
UniProt:Q96HS1 PGAM5
0.527
3
UniProt:Q9Y3R4 NEU2
1
NEU2 [cytosol]
(R-HSA-1605759)
0.527
2
UniProt:P54274 TERF1
1
TERF1 [nucleoplasm]
(R-HSA-164618)
0.508
2
UniProt:O88351
2
phospho-p-S177,S181-IKBKB [cytosol]
(R-MMU-202506)
IKBKB [cytosol]
(R-MMU-168114)
0.508
2
UniProt:P15314
1
Irf1 [nucleoplasm]
(R-MMU-983456)
0.499
2
UniProt:P58004 SESN2
1
SESN2 [cytosol]
(R-HSA-5629143)
0.499
3
UniProt:Q5JTC6 AMER1
5
AMER1 [cytosol]
(R-HSA-1504189)
AMER1 R353* [cytosol]
(R-HSA-9663939)
AMER1 R358* [cytosol]
(R-HSA-4839640)
AMER1 S210* [cytosol]
(R-HSA-5251492)
AMER1 R497* [cytosol]
(R-HSA-9663943)
0.499
2
UniProt:Q9UF56 FBXL17
1
FBXL17 [nucleoplasm]
(R-HSA-9708570)
0.462
7
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