Reactome | Ub-STAM2 [cytosol]

Ub-STAM2 [cytosol]

Stable Identifier

R-HSA-6782781

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Signal transducing adapter molecule 2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O75886 STAM2

Gene Names

STAM2, HBP

Chain

chain:1-525

Reference Genes

BioGPS Gene:10254 STAM2

COSMIC (genes):STAM2 STAM2

CTD Gene:10254 STAM2

dbSNP Gene:10254 STAM2

ENSEMBL:ENSG00000115145 STAM2

ENSEMBL_homo_sapiens_GENE:ENSG00000115145.10 STAM2

HGNC:11358 STAM2

KEGG Gene (Homo sapiens):10254 STAM2

Monarch:10254 STAM2

NCBI Gene:10254 STAM2

OMIM:606244 STAM2

UCSC:O75886 STAM2

Reference Transcript

RefSeq:NM_005843.5 STAM2

Other Identifiers

10254

11731592_at

11731593_a_at

11731594_at

11731595_x_at

16903794

208194_PM_s_at

208194_s_at

209649_PM_at

209649_at

215044_PM_s_at

215044_s_at

228254_3p_at

228254_PM_at

228254_at

242569_PM_at

242569_at

2581431

2581432

2581433

2581434

2581435

2581436

2581438

2581440

2581443

2581445

2581446

2581447

2581450

2581451

2581452

2581453

2581454

2581455

2581456

2581458

2581459

38525_at

50573_r_at

60468_at

8055890

A_23_P209215

A_24_P62860

GE535132

GE56632

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005829

GO:0006886

GO:0006914

GO:0007165

GO:0008289

GO:0015031

GO:0016020

GO:0016192

GO:0016236

GO:0023052

GO:0030139

GO:0030163

GO:0031410

GO:0031901

GO:0033565

GO:0035091

GO:0036258

GO:0043130

GO:0043226

GO:0043231

GO:0043328

GO:0061024

GO:0090148

HMNXSV003039950

Hs.114624.0.A1_3p_at

Hs.114624.0.A1_3p_x_at

Hs.123778.0.A1_3p_at

Hs.306650.0.S1_3p_s_at

ILMN_1781135

PH_hs_0027585

TC02002432.hg

g5032126_3p_a_at

g6599205_3p_at

Participates

as a component of

USP8:Ub-STAM2:HGS [cytosol] (Homo sapiens)

Other forms of this molecule

STAM2 [cytosol]

Inferred To

Ub-STAM2 [cytosol] (Gallus gallus)

Stam [cytosol] (Drosophila melanogaster)

STAM2 [cytosol] (Bos taurus)

STAM2 [cytosol] (Canis familiaris)

STAM2 [cytosol] (Sus scrofa)

Stam2 [cytosol] (Mus musculus)

Stam2 [cytosol] (Rattus norvegicus)

stam2 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

ubiquitinylated lysine (polyubiquitin chain [cytosol]) at unknown position

Modification

polyubiquitin chain [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_005834.4

OpenTargets

ENSG00000115145

GeneCards

O75886

HPA

ENSG00000115145-STAM2

Ensembl

ENST00000263904, ENSP00000263904, ENSG00000115145

PRO

O75886

Pharos - Targets

O75886

PDB

2L0T, 5CRV, 5IXF, 1X5B, 1X2Q

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95630 STAMBP	1	STAMBP [cytosol] (R-HSA-5693063)	0.839	9
UniProt:Q13094 LCP2	2	p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175) LCP2 [cytosol] (R-HSA-202306)	0.788	9
UniProt:Q969R5 L3MBTL2	2	L3MBTL2 [nucleoplasm] (R-HSA-6804477) polySUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480)	0.666	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.583	3
UniProt:P02545 LMNA	3	LMNA(1-646) [nuclear envelope] (R-HSA-535479) LMNA(1-567)-RAF1(279-648) fusion [cytosol] (R-HSA-6802399) LMNA(1-567)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802537)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:O00311 CDC7	1	CDC7 [nucleoplasm] (R-HSA-51781)	0.556	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.547	3
UniProt:Q92783 STAM	1	STAM [cytosol] (R-HSA-182925)	0.527	3
UniProt:P23458 JAK1	6	p-Y1034,Y1035-JAK1 [cytosol] (R-HSA-9005335) JAK1 [endosome] (R-HSA-8983168) p-JAK1 [cytosol] (R-HSA-8950711) p-Y1034-JAK1 [cytosol] (R-HSA-1112543) JAK1 [cytosol] (R-HSA-451898) p-Y-JAK1 [cytosol] (R-HSA-451921)	0.502	2

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