Reactome | PolyUb-IFIH1 [cytosol]

PolyUb-IFIH1 [cytosol]

Stable Identifier

R-HSA-6782812

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IFIH1, MDA5, Interferon-induced helicase C domain-containing protein 1

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Homo sapiens)
        
        USP17:PolyUb-RCE1, PolyUb-CDC25A, PolyUb-DDX58, PolyUb-IFIH1 [cytosol] (Homo sapiens)
        
        PolyUb-RCE1, PolyUb-CDC25A, PolyUb-DDX58, PolyUb-IFIH1 [cytosol] (Homo sapiens)
        
        PolyUb-IFIH1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BYX4 IFIH1

Gene Names

IFIH1, MDA5, RH116

Chain

chain:1-1025

Reference Genes

BioGPS Gene:64135 IFIH1

COSMIC (genes):IFIH1 IFIH1

CTD Gene:64135 IFIH1

dbSNP Gene:64135 IFIH1

ENSEMBL:ENSG00000115267 IFIH1

ENSEMBL_homo_sapiens_GENE:ENSG00000115267.10 IFIH1

HGNC:18873 IFIH1

KEGG Gene (Homo sapiens):64135 IFIH1

Monarch:64135 IFIH1

NCBI Gene:64135 IFIH1

OMIM:606951 IFIH1

UCSC:Q9BYX4 IFIH1

Reference Transcript

RefSeq:NM_022168.3 IFIH1

Other Identifiers

11724346_a_at

11761686_at

1555464_PM_at

1555464_at

16904365

219209_PM_at

219209_at

2584208

2584209

2584210

2584211

2584213

2584215

2584216

2584218

2584219

2584220

2584221

2584222

2584223

2584224

2584225

2584226

2584227

2584228

2584229

2584230

2584234

2584235

2584236

2584238

2584239

2584240

2584241

2584242

51920_at

64135

8056285

GE62756

GO:0000166

GO:0002376

GO:0002753

GO:0003677

GO:0003723

GO:0003724

GO:0003725

GO:0003727

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005739

GO:0005829

GO:0008270

GO:0009597

GO:0009615

GO:0016787

GO:0016887

GO:0016925

GO:0023052

GO:0032727

GO:0032728

GO:0032755

GO:0032760

GO:0034344

GO:0036211

GO:0038187

GO:0039530

GO:0042802

GO:0043021

GO:0043226

GO:0045071

GO:0045087

GO:0046872

GO:0050896

GO:0051259

GO:0051607

GO:0060089

GO:0060337

GO:0060760

GO:0065003

GO:0071360

GO:0098542

GO:0098586

GO:0140098

GO:0140374

GO:0140640

GO:0140657

HMNXSV003051681

Hs2Affx.1.318.S1_3p_at

PH_hs_0024506

TC02002481.hg

g11545921_3p_at

Participates

as a member of

PolyUb-RCE1, PolyUb-CDC25A, PolyUb-DDX58, PolyUb-IFIH1 [cytosol] (Homo sapiens)

Other forms of this molecule

IFIH1 [cytosol]

K48polyUb-IFIH1 [cytosol]

Inferred To

helF [cytosol] (Dictyostelium discoideum)

Ifih1 [cytosol] (Rattus norvegicus)

Homologues of PolyUb-IFIH1 [cytosol] (Caenorhabditis elegans)

Homologues of PolyUb-IFIH1 [cytosol] (Saccharomyces cerevisiae)

ifih1 [cytosol] (Danio rerio)

drh-1 [cytosol] (Caenorhabditis elegans)

PolyUb-IFIH1 [cytosol] (Bos taurus)

PolyUb-IFIH1 [cytosol] (Caenorhabditis elegans)

PolyUb-IFIH1 [cytosol] (Canis familiaris)

PolyUb-IFIH1 [cytosol] (Mus musculus)

PolyUb-IFIH1 [cytosol] (Saccharomyces cerevisiae)

PolyUb-IFIH1 [cytosol] (Sus scrofa)

Modified Residues

Name

ubiquitinylated lysine (PolyUb [cytosol]) at unknown position

Modification

PolyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_071451.2

Guide to Pharmacology - Targets

2921

OpenTargets

ENSG00000115267

HPA

ENSG00000115267-IFIH1

GeneCards

Q9BYX4

Ensembl

ENST00000649979, ENST00000421365, ENSG00000115267, ENSP00000497271, ENSP00000408450

PRO

Q9BYX4

Pharos - Targets

Q9BYX4

Orphanet

22885

HMDB Protein

HMDBP11796

PDB

4GL2, 3GA3, 7DNI, 2RQB, 7JL2, 3B6E, 7DNJ, 7JL0

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.775	7
UniProt:P05161 ISG15	4	ISG15 [nucleoplasm] (R-HSA-5653665) K164-PCNA-G157-ISG15 [nucleoplasm] (R-HSA-5653745) ISG15 [cytosol] (R-HSA-936552) K168-PCNA-G157-ISG15 [nucleoplasm] (R-HSA-5653744)	0.623	7
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.621	3
UniProt:Q3LXA3 TKFC	1	TKFC [cytosol] (R-HSA-918185)	0.616	5
UniProt:Q14145 KEAP1	3	Ub-KEAP1 [cytosol] (R-HSA-6782766) ub-KEAP1 [cytosol] (R-HSA-9766647) KEAP1 [cytosol] (R-HSA-976038)	0.556	3
UniProt:O14730 RIOK3	1	RIOK3 [cytosol] (R-HSA-6791522)	0.543	6
UniProt:Q14164 IKBKE	5	monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535) IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) K63polyUb-K30,K401-IKBKE [cytosol] (R-HSA-9730436) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521)	0.499	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.463	2
UniProt:P0DTD2 9b	3	p-S53-9b [cytosol] (R-COV-9758478) 9b [cytosol] (R-COV-9694649) 9b [mitochondrial outer membrane] (R-COV-9709803)	0.463	2

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