TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe)

Stable Identifier
R-HSA-6782859
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe)
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TRMT5 transfers a methyl group from S-adenosylmethionine to the 1 position of guanosine-37 of tRNA(Phe) (Brulé et al. 2004, Christian et al. 2013). The yeast homolog, TRM5, catalyzes the same reaction.
Literature References
PubMed ID Title Journal Year
23887145 Conservation of structure and mechanism by Trm5 enzymes

Gamper, H, Christian, T, Hou, YM

RNA 2013
15248782 Isolation and characterization of the human tRNA-(N1G37) methyltransferase (TRM5) and comparison to the Escherichia coli TrmD protein

Elliott, M, Brulé, H, Holmes, WM, Redlak, M, Zehner, ZE

Biochemistry 2004
Participants
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Output
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Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

tRNA (guanine(37)-N(1))-methyltransferase activity of TRMT5 [nucleoplasm]

Physical Entity
TRMT5 [nucleoplasm] (Homo sapiens)
Activity
tRNA (guanine(37)-N(1))-methyltransferase activity (GO:0052906)
Inferred From
TRM5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe) (Saccharomyces cerevisiae)
Authored
May, B  (2015-06-08)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-06-09)
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