Reactome | PolyUb-MYC [nucleoplasm]

PolyUb-MYC [nucleoplasm]

Stable Identifier

R-HSA-6783169

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

MYC

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Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP28 deubiquitinates CLSPN and MYC (Homo sapiens)
        
        USP28:PolyUb-CLSPN, PolyUb-MYC [nucleoplasm] (Homo sapiens)
        
        PolyUb-CLSPN, PolyUb-MYC [nucleoplasm] (Homo sapiens)
        
        PolyUb-MYC [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01106 MYC

Gene Names

MYC, BHLHE39

Chain

chain:1-454

Reference Genes

BioGPS Gene:4609 MYC

COSMIC (genes):MYC MYC

CTD Gene:4609 MYC

dbSNP Gene:4609 MYC

ENSEMBL:ENSG00000136997 MYC

HGNC:7553 MYC

KEGG:hsa:4609 MYC

Monarch:4609 MYC

NCBI Gene:4609 MYC

OMIM:190080 MYC

UCSC:P01106 MYC

Reference Transcript

RefSeq:NM_002467.4 MYC

Other Identifiers

11745021_a_at

17072669

1827_s_at

1936_s_at

1973_s_at

202431_PM_s_at

202431_s_at

239931_PM_at

239931_at

3115510

3115511

3115512

3115513

3115514

3115515

3115516

3115517

3115518

3115519

3115520

3115521

3115522

3115523

3115524

3115525

3115526

3115527

37724_at

4609

69992_at

8148317

A_14_P123915

A_14_P128991

A_14_P137636

A_14_P138867

A_23_P215956

A_24_P178011

A_24_P38363

A_33_P3245163

GE57537

GE760380

GE85078

GO:0000082

GO:0000122

GO:0000165

GO:0000785

GO:0000978

GO:0000981

GO:0001046

GO:0001221

GO:0001227

GO:0001228

GO:0001658

GO:0002053

GO:0003677

GO:0003700

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005635

GO:0005654

GO:0005730

GO:0005737

GO:0005783

GO:0005791

GO:0006325

GO:0006338

GO:0006355

GO:0006357

GO:0006879

GO:0006974

GO:0008150

GO:0008284

GO:0009410

GO:0010332

GO:0010468

GO:0010564

GO:0010628

GO:0012501

GO:0016020

GO:0032204

GO:0032206

GO:0032873

GO:0032986

GO:0032991

GO:0034644

GO:0042802

GO:0043066

GO:0043226

GO:0043280

GO:0044027

GO:0044195

GO:0044346

GO:0044877

GO:0045656

GO:0045727

GO:0045893

GO:0045944

GO:0046983

GO:0048146

GO:0048147

GO:0050679

GO:0051276

GO:0051782

GO:0060633

GO:0070371

GO:0070848

GO:0070888

GO:0071074

GO:0071456

GO:0071466

GO:0071943

GO:0090096

GO:0090571

GO:0098772

GO:0140110

GO:0140297

GO:0140537

GO:1902255

GO:1902895

GO:1904672

GO:1905761

HMNXSV003025638

HMNXSV003038212

Hs.202453.0.A1_3p_at

ILMN_1680618

ILMN_2110908

L00058_at

M13929_s_at

PH_hs_0023009

TC08000749.hg

g12962934_3p_a_at

Participates

as a member of

PolyUb-CLSPN, PolyUb-MYC [nucleoplasm] (Homo sapiens)

Other forms of this molecule

MYC [nucleoplasm]

Inferred To

Myc [nucleoplasm] (Mus musculus)

Myc [nucleoplasm] (Rattus norvegicus)

MYC [nucleoplasm] (Bos taurus)

MYC [nucleoplasm] (Canis familiaris)

MYC [nucleoplasm] (Gallus gallus)

MYC [nucleoplasm] (Sus scrofa)

Modified Residues

Name

ubiquitinylated lysine (PolyUb [nucleoplasm]) at unknown position

Modification

PolyUb [nucleoplasm]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_002458.2

OpenTargets

ENSG00000136997

ENSEMBL

ENSP00000499105, ENSP00000516745, ENSP00000478887, ENSP00000367207, ENST00000621592, ENST00000652288, ENST00000707116, ENST00000707113, ENST00000707115, ENST00000707114, ENSP00000430235, ENST00000524013, ENSP00000516742, ENSP00000516743, ENSP00000516744

HPA

ENSG00000136997-MYC

ZINC - Substances

MYC_HUMAN

ZINC target

P01106

PRO

P01106

Pharos - Targets

P01106

GlyGen

P01106

Orphanet

MYC

ZINC - Predictions - Purchasable

MYC_HUMAN

PDB

5I50, 5I4Z, 6C4U, 6E16, 1A93, 6G6L, 8OTT, 6G6K, 7T1Y, 8X8V, 2A93, 8OTS, 8X8S, 8Q1N, 8J2Q, 6G6J, 6E24, 8WLG, 1MV0, 7T1Z, 1EE4, 2OR9, 1NKP, 4Y7R

Interactors (148)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61244 MAX	1	MAX [nucleoplasm] (R-HSA-3006627)	0.982	50
UniProt:Q9Y4A5 TRRAP	1	TRRAP [nucleoplasm] (R-HSA-3322951)	0.886	8
UniProt:Q969H0 FBXW7	1	FBXW7 [cytosol] (R-HSA-391304)	0.832	7
UniProt:Q13105 ZBTB17	1	ZBTB17 [nucleoplasm] (R-HSA-535577)	0.775	9
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.775	20
UniProt:Q96L91 EP400	1	EP400 [nucleoplasm] (R-HSA-3321987)	0.763	6
UniProt:Q9Y5Q9 GTF3C3	1	GTF3C3 [nucleoplasm] (R-HSA-83691)	0.75	5
UniProt:Q8N163 CCAR2	2	DBC1 [nucleoplasm] (R-HSA-3371479) p-T454-DBC1 [nucleoplasm] (R-HSA-3371569)	0.749	9
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.731	7
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.71	5
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.69	4
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.688	5
UniProt:Q15029 EFTUD2	1	EFTUD2 [nucleoplasm] (R-HSA-71883)	0.677	6
UniProt:O94906 PRPF6	1	PRPF6 [nucleoplasm] (R-HSA-71881)	0.669	3
UniProt:Q9NTJ3 SMC4	3	SMC4 [nucleoplasm] (R-HSA-1629795) SMC4 [cytosol] (R-HSA-2517876) p-S-SMC4 [cytosol] (R-HSA-2529018)	0.669	3
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.669	3
UniProt:P42704 LRPPRC	1	LRPPRC [mitochondrial matrix] (R-HSA-5336174)	0.669	3
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.666	4
UniProt:Q9UBB4 ATX10			0.666	4
UniProt:P55084 HADHB	1	HADHB [mitochondrial inner membrane] (R-HSA-77266)	0.643	3
UniProt:Q14669 TRIP12	1	TRIP12 [cytosol] (R-HSA-976046)	0.632	7
UniProt:P52164	1	Max [nucleoplasm] (R-RNO-3006627)	0.632	4
UniProt:Q8TAD8 SNIP1	1	SNIP1 [nucleoplasm] (R-HSA-3222315)	0.625	9
UniProt:O15169 AXIN1	11	AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) ub-AXIN1 [cytosol] (R-HSA-4641133) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503)	0.623	10
UniProt:Q62141	1	Sin3b [nucleoplasm] (R-MMU-349685)	0.616	8
UniProt:O96019 ACTL6A	1	ACTL6A [nucleoplasm] (R-HSA-2980912)	0.615	3
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.615	3
UniProt:P03204 EBNA6			0.61	11
UniProt:O75182 SIN3B	1	SIN3B [nucleoplasm] (R-HSA-3006450)	0.607	7
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.602	4
UniProt:P49841 GSK3B	4	GSK3B [cytosol] (R-HSA-2997551) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [nucleoplasm] (R-HSA-2022823) GSK3B del304-316 [cytosol] (R-HSA-5339682)	0.597	3
UniProt:O00499-10 BIN1			0.593	3
UniProt:P11802 CDK4	3	p-T172-CDK4 [nucleoplasm] (R-HSA-113830) CDK4 [nucleoplasm] (R-HSA-113843) CDK4 [cytosol] (R-HSA-68330)	0.592	2
UniProt:Q8N3Y1 FBXW8	1	FBXW8 [cytosol] (R-HSA-976017)	0.567	3
UniProt:P06788 VE7			0.567	5
UniProt:Q13263 TRIM28	3	TRIM28 [nucleoplasm] (R-HSA-974998) SUMO2-K554,K575,K676,K750,K779,K804-TRIM28 [nucleoplasm] (R-HSA-9842867) SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm] (R-HSA-3782600)	0.564	2
UniProt:O95347 SMC2	2	SMC2 [cytosol] (R-HSA-2517875) SMC2 [nucleoplasm] (R-HSA-1629792)	0.564	2
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.564	2
UniProt:Q92922 SMARCC1	1	SMARCC1 [nucleoplasm] (R-HSA-389257)	0.564	2
UniProt:O00567 NOP56	2	NOP56 [nucleoplasm] (R-HSA-6790696) NOP56 [cytosol] (R-HSA-391293)	0.564	2
UniProt:Q9UHI6 DDX20	2	DDX20 [nucleoplasm] (R-HSA-191847) DDX20 [cytosol] (R-HSA-191838)	0.564	2
UniProt:Q8TEX9 IPO4			0.564	2
UniProt:P17480 UBTF	2	UBTF [nucleoplasm] (R-HSA-73683) p-UBTF [nucleoplasm] (R-HSA-76039)	0.564	2
UniProt:Q9Y678 COPG1	4	COPG1 [endoplasmic reticulum membrane] (R-HSA-6810960) COPG1 [Golgi membrane] (R-HSA-6808747) COPG1 [transport vesicle] (R-HSA-6808749) COPG1 [cytosol] (R-HSA-199987)	0.564	2
UniProt:P17812 CTPS1	1	CTPS1 [cytosol] (R-HSA-73536)	0.564	2
UniProt:Q96T76 MMS19	1	MMS19 [cytosol] (R-HSA-2161121)	0.564	2
UniProt:Q9NTI5 PDS5B	4	PDS5B [cytosol] (R-HSA-2484800) PDS5B [chromosome] (R-HSA-2466361) PDS5B [chromosome, centromeric region] (R-HSA-2468263) PDS5B [nucleoplasm] (R-HSA-2468051)	0.564	2
UniProt:P35249 RFC4	1	RFC4 [nucleoplasm] (R-HSA-68429)	0.564	2
UniProt:P30876 POLR2B	1	POLR2B [nucleoplasm] (R-HSA-63504)	0.564	2
UniProt:O60313 OPA1	4	OPA1 [mitochondrial inner membrane] (R-HSA-8867508) OPA1(88-194) [mitochondrial inner membrane] (R-HSA-8867509) OPA1(195-960) [mitochondrial inner membrane] (R-HSA-8867513) OPA1 [mitochondrial inner membrane] (R-HSA-5333636)	0.564	2
UniProt:Q13576 IQGAP2	3	IQGAP2 [plasma membrane] (R-HSA-6804811) IQGAP2 [secretory granule membrane] (R-HSA-6804779) IQGAP2 [cytosol] (R-HSA-5625975)	0.564	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.564	2
UniProt:P56192 MARS1	1	MARS [cytosol] (R-HSA-379657)	0.564	2
UniProt:Q92974 ARHGEF2	1	ARHGEF2 [cytosol] (R-HSA-195101)	0.564	2
UniProt:Q8WUM0 NUP133	2	NUP133 [nuclear envelope] (R-HSA-157743) NUP133 [cytosol] (R-HSA-376251)	0.564	2
UniProt:Q07864 POLE	1	POLE [nucleoplasm] (R-HSA-68473)	0.564	2
UniProt:Q9GZR7 DDX24			0.564	2
UniProt:Q9HAV4 XPO5	2	XPO5 [cytosol] (R-HSA-847719) XPO5 [nucleoplasm] (R-HSA-847721)	0.564	2
UniProt:Q8N1F7 NUP93	2	NUP93 [cytosol] (R-HSA-9634167) NUP93 [nuclear envelope] (R-HSA-157749)	0.564	2
UniProt:Q3KQU3 MA7D1			0.564	2
UniProt:O75643 SNRNP200	1	SNRNP200 [nucleoplasm] (R-HSA-71885)	0.564	2
UniProt:P16615 ATP2A2	2	ATP2A2 [platelet dense tubular network membrane] (R-HSA-427903) ATP2A2 [endoplasmic reticulum membrane] (R-HSA-391962)	0.564	2
UniProt:Q96P70 IPO9			0.564	2
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.564	2
UniProt:Q9BQG0 MYBBP1A	1	MYBBP1A [nucleoplasm] (R-HSA-5250650)	0.564	2
UniProt:Q9NRZ9 HELLS	1	HELLS [nucleoplasm] (R-HSA-9839382)	0.564	2
UniProt:Q13085 ACACA	2	ACACA [cytosol] (R-HSA-1660609) Btn-ACACA [cytosol] (R-HSA-2976730)	0.564	2
UniProt:P52701 MSH6	2	MSH6 L222* [nucleoplasm] (R-HSA-5632954) MSH6 [nucleoplasm] (R-HSA-5357528)	0.564	2
UniProt:A5D8W4 A5D8W4			0.556	3
UniProt:P55212 CASP6	5	CASP6(194-293) [cytosol] (R-HSA-266128) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:Q13148 TADBP			0.556	6
UniProt:Q01658 DR1	1	DR1 [nucleoplasm] (R-HSA-3662280)	0.556	3
UniProt:O75400-2 PRPF40A			0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 [plasma membrane] (R-HSA-170842) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905)	0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
UniProt:Q9Y371 SHLB1			0.556	3
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:P28329-3 P283293			0.556	3
UniProt:Q00403 GTF2B	1	GTF2B [nucleoplasm] (R-HSA-65888)	0.556	3
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.556	3
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940)	0.556	3
UniProt:P06307 CCK	1	CCK [extracellular region] (R-HSA-388539)	0.556	3
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.556	3
UniProt:P17980 PSMC3	5	PSMC3 [cytosol] (R-HSA-68774) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429)	0.547	2
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.547	2
UniProt:Q92616 GCN1	1	GCN1 [cytosol] (R-HSA-9633010)	0.547	2
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.547	2
UniProt:Q8TCG1 CIP2A			0.544	2
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.536	2
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591)	0.536	2
UniProt:P68366 TUBA4A	9	TUBA4A [cytosol] (R-HSA-191694) TUBA4A [axonemal microtubule] (R-HSA-5610443) TUBA4A [extracellular region] (R-HSA-350734) Polyglutamyl-TUBA4A [cytosol] (R-HSA-8867386) L-isoglutamyl polyglycyl-TUBA4A [cytosol] (R-HSA-8867378) TUBA4A unfolded [cytosol] (R-HSA-392771) TUBA4A folding intermediate [cytosol] (R-HSA-392800) Ac K40 TUBA4A [axonemal microtubule] (R-HSA-5624859) AcK-TUBA4A [cytosol] (R-HSA-5618318)	0.527	5
UniProt:Q9UKN8 GTF3C4	1	GTF3C4 [nucleoplasm] (R-HSA-83689)	0.527	2
UniProt:P56134 ATP5MF	1	ATP5MF [mitochondrial inner membrane] (R-HSA-50516)	0.527	2
UniProt:Q15678 PTPN14	1	PTPN14 [nucleoplasm] (R-HSA-9008917)	0.527	2
UniProt:P36542 ATP5F1C	1	ATP5F1C [mitochondrial matrix] (R-HSA-164577)	0.527	2
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.527	3
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.527	2
UniProt:P02545 LMNA	3	LMNA(1-567)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802537) LMNA(1-567)-RAF1(279-648) fusion [cytosol] (R-HSA-6802399) LMNA(1-646) [nuclear envelope] (R-HSA-535479)	0.527	3
UniProt:Q6PIV2 FOXR1			0.527	3
UniProt:Q9BRK5 CAB45			0.527	2
UniProt:Q14697 GANAB	1	GANAB [endoplasmic reticulum lumen] (R-HSA-532674)	0.527	2
UniProt:O60762 DPM1	4	DPM1 R92G [endoplasmic reticulum membrane] (R-HSA-4717370) DPM1 Q210Rfs4 [endoplasmic reticulum membrane] (R-HSA-4717361) DPM1 G111Lfs45 [endoplasmic reticulum membrane] (R-HSA-4717383) DPM1 [endoplasmic reticulum membrane] (R-HSA-162865)	0.527	2
IntAct:EBI-6620396 PYR1			0.527	2
UniProt:Q15233 NONO			0.527	2
UniProt:Q6PJQ5 FOXR2			0.527	2
UniProt:O75306 NDUFS2	1	NDUFS2 [mitochondrial matrix] (R-HSA-6788520)	0.527	2
UniProt:P0C0S5 H2AZ1	1	H2AFZ [extracellular region] (R-HSA-977575)	0.527	2
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.527	2
UniProt:Q9Y6N5 SQRDL	3	2xHC-SQRDL(1-450) [mitochondrial inner membrane] (R-HSA-1614613) SQRDL(1-450) [mitochondrial inner membrane] (R-HSA-1614646) CysS-SQRDL(1-450) [mitochondrial inner membrane] (R-HSA-1614576)	0.527	2
UniProt:O43823 AKAP8			0.527	2
UniProt:P53597 SUCLG1	1	SUCLG1 [mitochondrial matrix] (R-HSA-156623)	0.527	2
UniProt:P24928 POLR2A	7	POLR2A [nucleoplasm] (R-HSA-63502) p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-113420) p-3S-POLR2A [nucleoplasm] (R-HSA-6797701) Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-6781855) p-S5(CTD)-POLR2A [nucleoplasm] (R-HSA-77100) p-S5,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6810226) p-S2,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6814543)	0.527	4
UniProt:P78346 RPP30	1	RPP30 [nucleoplasm] (R-HSA-5696779)	0.527	2
UniProt:O60264 SMARCA5	1	SMARCA5 [nucleoplasm] (R-HSA-417140)	0.527	2
UniProt:Q9Y6M1 IGF2BP2	1	IGF2BP2 [cytosol] (R-HSA-428302)	0.527	2
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.527	2
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435)	0.527	3
UniProt:P26641 EEF1G	3	EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol] (R-HSA-9710850) EEF1G(1-343)-ALK(1106-1620) fusion [cytosol] (R-HSA-9710839) EEF1G [cytosol] (R-HSA-156925)	0.527	2
UniProt:Q8N6T7 SIRT6	1	SIRT6 [nucleoplasm] (R-HSA-5685963)	0.524	3
UniProt:O43524 FOXO3	11	FOXO3 [nucleoplasm] (R-HSA-199305) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) FOXO3 [cytosol] (R-HSA-5687032) p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010)	0.524	3
UniProt:Q86XR8 CEP57	1	CEP57 [cytosol] (R-HSA-380271)	0.524	3
UniProt:Q15059 BRD3			0.524	3
UniProt:P04020 VE7			0.508	2
UniProt:A9UHW6 MI4GD			0.508	2
UniProt:P03129 VE7			0.508	2
UniProt:O00499-11 BIN1			0.508	2
UniProt:O95983 MBD3	1	MBD3 [nucleoplasm] (R-HSA-4657010)	0.499	3
UniProt:P03070 LT			0.499	2
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.499	2
IntAct:EBI-1648030 CDK4			0.499	2
UniProt:O75928 PIAS2	1	PIAS2 [nucleoplasm] (R-HSA-2993787)	0.499	4
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.499	4
UniProt:O95619 YEATS4	1	YEATS4 [nucleoplasm] (R-HSA-3322940)	0.483	2
UniProt:Q03164 KMT2A	6	KMT2A [cytosol] (R-HSA-9818584) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593)	0.483	2
UniProt:P04843 RPN1	1	RPN1 [endoplasmic reticulum membrane] (R-HSA-264994)	0.483	2
UniProt:Q9NV56 MRGBP	1	MRGBP [nucleoplasm] (R-HSA-3322953)	0.483	2
UniProt:P40939 HADHA	1	HADHA [mitochondrial inner membrane] (R-HSA-77264)	0.483	2
UniProt:Q9H2F5 EPC1	1	EPC1 [nucleoplasm] (R-HSA-3321978)	0.483	2
UniProt:P58317 ZN121			0.482	2
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.463	3
UniProt:O15111 CHUK	4	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615) p-Y187,Y198-CHUK [cytosol] (R-HSA-9861501)	0.463	3
UniProt:P12956 XRCC6	5	XRCC6 [nucleoplasm] (R-HSA-58272) XRCC6 [cytosol] (R-HSA-3134813) XRCC6 [secretory granule lumen] (R-HSA-6801312) XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300)	0.462	3
UniProt:Q15022 SUZ12	2	SUZ12 [nucleoplasm] (R-HSA-212217) monoSUMO1-K75-SUZ12 [nucleoplasm] (R-HSA-4615932)	0.462	4
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.462	2
UniProt:Q9DH70 Q9DH70			0.462	2
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.462	6

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