Unknown hydroxyproline carrier transports cytosolic HPRO into the mitochondrial matrix

Stable Identifier
R-HSA-6784213
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol, mitochondrial matrix
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Unknown hydroxyproline carrier transports cytosolic HPRO into the mitochondrial matrix
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cytosolic hydroxyproline (HPRO) is transported into the mitochonrial matrix in a saturable process distinct from the one responsible for proline uptake. The carrier that mediates this process has not been identified, however (Atlante et al. 1996).
Literature References
PubMed ID Title Journal Year
8915003 Carrier-mediated transport controls hydroxyproline catabolism in heart mitochondria from spontaneously hypertensive rat

Vulpis, V, Passarella, S, Seccia, TM, Minervini, GM, Pirrelli, A, Marra, E, Atlante, A

FEBS Lett. 1996
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
hydroxyproline transport (0034589)
Catalyst Activity

L-hydroxyproline transmembrane transporter activity of HPRO carrier [mitochondrial inner membrane]

Physical Entity
HPRO carrier [mitochondrial inner membrane] (Homo sapiens)
Activity
L-hydroxyproline transmembrane transporter activity (GO:0034590)
Authored
D'Eustachio, P  (2015-06-19)
Reviewed
Jassal, B  (2016-12-23)
Created
D'Eustachio, P  (2015-06-19)
Cite Us!