Reactome | PCSK9 [extracellular region]

PCSK9 [extracellular region]

Stable Identifier

R-HSA-6784727

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Proprotein convertase subtilisin/kexin type 9 ecNumber3.4.21.-/ecNumber, PCSK9_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P01130 LDLR

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External Reference Information

External Reference

UniProt:Q8NBP7 PCSK9

Gene Names

PCSK9, NARC1, PSEC0052

Chain

signal peptide:1-30, propeptide:31-152, chain:153-692

Reference Genes

BioGPS Gene:255738 PCSK9

COSMIC (genes):PCSK9 PCSK9

CTD Gene:255738 PCSK9

dbSNP Gene:255738 PCSK9

ENSEMBL:ENSG00000169174 PCSK9

HGNC:20001 PCSK9

KEGG:hsa:255738 PCSK9

Monarch:255738 PCSK9

NCBI Gene:255738 PCSK9

OMIM:607786 PCSK9

UCSC:Q8NBP7 PCSK9

Reference Transcript

RefSeq:NM_174936.3 PCSK9

Participates

as a component of

as an input of

Other forms of this molecule

PCSK9 [endoplasmic reticulum lumen]

p-PCSK9 [endoplasmic reticulum lumen]

PCSK9 [lysosomal membrane]

PCSK9 [endolysosome membrane]

Inferred To

Homologues of PCSK9 [extracellular region] (Saccharomyces cerevisiae)

Homologues of PCSK9 [extracellular region] (Schizosaccharomyces pombe)

isp6 [extracellular region] (Schizosaccharomyces pombe)

Pcsk9 [extracellular region] (Mus musculus)

Pcsk9 [extracellular region] (Rattus norvegicus)

pcsk9 [extracellular region] (Xenopus tropicalis)

YSP3 [extracellular region] (Saccharomyces cerevisiae)

PCSK9 [extracellular region] (Gallus gallus)

PCSK9 [extracellular region] (Sus scrofa)

RRT12 [extracellular region] (Saccharomyces cerevisiae)

psp3 [extracellular region] (Schizosaccharomyces pombe)

PRB1 [extracellular region] (Saccharomyces cerevisiae)

Ghost homologue of PCSK9 [extracellular region] (Bos taurus)

Ghost homologue of PCSK9 [extracellular region] (Caenorhabditis elegans)

Ghost homologue of PCSK9 [extracellular region] (Canis familiaris)

Ghost homologue of PCSK9 [extracellular region] (Dictyostelium discoideum)

Ghost homologue of PCSK9 [extracellular region] (Drosophila melanogaster)

Cross References

Guide to Pharmacology - Targets

2388

OpenTargets

ENSG00000169174

ENSEMBL

ENSP00000303208, ENST00000302118, ENSG00000169174

ZINC - Substances

PCSK9_HUMAN

ZINC target

Q8NBP7

PRO

Q8NBP7

GlyGen

Q8NBP7

PDB

6OM7, 3GCW, 6OLZ, 2QTW, 6U3X, 6U26, 7ANQ, 6U2F, 4K8R, 6E4Y, 6E4Z, 6U2N, 4OV6, 5VLL, 5VLK, 3H42, 5VL7, 6MV5, 6U2P, 2P4E, 5VLH, 5VLA, 6U36, 2W2Q, 6U38, 5VLP, 4NMX, 3M0C, 2PMW, 6OM0, 3P5B, 5OCA, 6U3I, 3GCX, 2XTJ, 3P5C, 3BPS, 2W2M, 4NE9, 3SQO, 2W2N, 2W2O, 2W2P

HPA

ENSG00000169174-PCSK9

GeneCards

PCSK9

Pharos - Targets

Q8NBP7

Orphanet

PCSK9

ZINC - Predictions - Purchasable

PCSK9_HUMAN

HMDB Protein

HMDBP07935

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01130 LDLR	4	LDLR [plasma membrane] (R-HSA-171053) LDLR [clathrin-coated endocytic vesicle membrane] (R-HSA-171105) LDLR [endosome membrane] (R-HSA-171127) LDLR [endolysosome membrane] (R-HSA-6784818)	0.676	10
UniProt:P08253 MMP2	5	MMP2(110-660) [extracellular region] (R-HSA-381456) MMP2(30-660) [extracellular region] (R-HSA-1604364) MMP2(30-66) [extracellular region] (R-HSA-1604347) MMP2(67-660) [extracellular region] (R-HSA-1604345) MMP2(67-109) [extracellular region] (R-HSA-1604371)	0.618	4
UniProt:P07355 ANXA2	6	ANXA2 [azurophil granule lumen] (R-HSA-6798766) ANXA2 [extracellular region] (R-HSA-6806242) p-S26-ANXA2 [cytosol] (R-HSA-9865163) p-Y24,S26-ANXA2 [cytosol] (R-HSA-9865224) ANXA2 [cytosol] (R-HSA-5263667) ANXA2 [external side of plasma membrane] (R-HSA-5336164)	0.61	7
IntAct:EBI-8785901 ANXA2			0.524	2

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