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AP2A2(1-939) [endolysosome membrane]
Stable Identifier
R-HSA-6784819
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endolysosome membrane
Synonyms
Adaptor protein AP2A2
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Internalization of MHC II:Ii clathrin coated vesicle (Homo sapiens)
Clathrin coated MHC class II alpha/beta/Ii nonamer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Homo sapiens)
AP2A2(1-939) [endolysosome membrane] (Homo sapiens)
Uncoating of clathrin-coated vesicles and fusion with endosomes (Homo sapiens)
Clathrin coated MHC class II alpha/beta/Ii nonamer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Homo sapiens)
AP2A2(1-939) [endolysosome membrane] (Homo sapiens)
Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Homo sapiens)
AP2A2(1-939) [endolysosome membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein clearance (Homo sapiens)
LDL clearance (Homo sapiens)
Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Homo sapiens)
Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Homo sapiens)
AP2A2(1-939) [endolysosome membrane] (Homo sapiens)
PCSK9:LDLR:Clathrin:AP2 [endolysosome membrane] (Homo sapiens)
Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Homo sapiens)
AP2A2(1-939) [endolysosome membrane] (Homo sapiens)
PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Homo sapiens)
PCSK9:LDLR:Clathrin:AP2 [endolysosome membrane] (Homo sapiens)
Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Homo sapiens)
AP2A2(1-939) [endolysosome membrane] (Homo sapiens)
VLDLR internalisation and degradation (Homo sapiens)
VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Homo sapiens)
VLDL:PCSK9:Clathrin:AP2 [lysosomal membrane] (Homo sapiens)
Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Homo sapiens)
AP2A2(1-939) [endolysosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O94973 AP2A2
Gene Names
AP2A2, ADTAB, CLAPA2, HIP9, HYPJ, KIAA0899
Chain
chain:1-939
Reference Genes
BioGPS Gene:161 AP2A2
COSMIC (genes):AP2A2 AP2A2
CTD Gene:161 AP2A2
dbSNP Gene:161 AP2A2
ENSEMBL:ENSG00000183020 AP2A2
ENSEMBL_homo_sapiens_GENE:ENSG00000183020.15 AP2A2
HGNC:562 AP2A2
KEGG Gene (Homo sapiens):161 AP2A2
Monarch:161 AP2A2
NCBI Gene:161 AP2A2
OMIM:607242 AP2A2
UCSC:O94973 AP2A2
Reference Transcript
RefSeq:NM_012305.3 AP2A2
RefSeq:NM_001242837.1 AP2A2
Other Identifiers
11741016_a_at
11741017_s_at
11755014_a_at
161
16720440
211779_PM_x_at
211779_x_at
212159_PM_x_at
212159_x_at
212161_3p_at
212161_PM_at
212161_at
215764_3p_x_at
215764_PM_x_at
215764_x_at
32228_at
3316451
3316452
3316453
3316454
3316455
3316471
3316477
3316481
3316484
3316488
3316492
3316493
3316494
3316502
3316508
3316512
3316514
3316515
3316516
3316520
3316528
3316532
3316540
3316542
3316543
3316544
3316546
3316547
3316548
3316549
3316550
3316551
3316552
3316553
3316554
3316555
3316556
3316557
3316558
3316559
3316560
3316562
7937533
A_14_P126629
A_23_P21853
A_24_P339974
A_24_P932418
A_33_P3311863
GE53571
GO:0003674
GO:0005515
GO:0005764
GO:0005768
GO:0005773
GO:0005829
GO:0005886
GO:0005905
GO:0006886
GO:0006897
GO:0008289
GO:0009898
GO:0015031
GO:0016020
GO:0016192
GO:0019900
GO:0019901
GO:0019904
GO:0030117
GO:0030122
GO:0030131
GO:0030666
GO:0030667
GO:0030669
GO:0031410
GO:0035615
GO:0036020
GO:0043226
GO:0045334
GO:0060090
GO:0072583
GO:0097718
GO:0098794
GO:0098884
GO:0101003
HMNXSV003023222
HMNXSV003045833
Hs.19121.0.S2_3p_a_at
Hs.19121.0.S2_3p_at
Hs.19121.0.S2_3p_x_at
Hs.19121.1.S1_3p_a_at
Hs.19121.1.S1_3p_at
ILMN_1803779
PH_hs_0001684
TC11000036.hg
g13544040_3p_s_at
Participates
as a member of
Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Homo sapiens)
Other forms of this molecule
AP2A2(1-939) [ficolin-1-rich granule membrane]
AP2A2(1-939) [secretory granule membrane]
AP2A2(1-939) [plasma membrane]
AP2A2(1-939) [clathrin-coated endocytic vesicle membrane]
AP2A2(1-939) [cytosol]
Inferred To
apl3 [endolysosome membrane]
(Schizosaccharomyces pombe)
AP-2alpha [endolysosome membrane]
(Drosophila melanogaster)
ap2a1-2 [endolysosome membrane]
(Dictyostelium discoideum)
APL3 [endolysosome membrane]
(Saccharomyces cerevisiae)
AP2A2(1-939) [endolysosome membrane]
(Bos taurus)
AP2A2(1-939) [endolysosome membrane]
(Caenorhabditis elegans)
AP2A2(1-939) [endolysosome membrane]
(Canis familiaris)
AP2A2(1-939) [endolysosome membrane]
(Gallus gallus)
AP2A2(1-939) [endolysosome membrane]
(Mus musculus)
AP2A2(1-939) [endolysosome membrane]
(Rattus norvegicus)
AP2A2(1-939) [endolysosome membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001229766.1
,
NP_036437.1
OpenTargets
ENSG00000183020
HPA
ENSG00000183020-AP2A2
GeneCards
O94973
Ensembl
ENSP00000431630
,
ENSG00000183020
,
ENST00000448903
,
ENSP00000413234
,
ENSP00000327694
,
ENST00000528815
,
ENST00000332231
PRO
O94973
Pharos - Targets
O94973
HMDB Protein
HMDBP14130
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.643
5
UniProt:P29353 SHC1
5
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
SHC1 [cytosol]
(R-HSA-74680)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
0.643
4
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.569
4
UniProt:P42566 EPS15
2
p-Y849 EPS15 [cytosol]
(R-HSA-8867028)
EPS15 [cytosol]
(R-HSA-182920)
0.527
2
UniProt:P98078
3
Dab2 [cytosol]
(R-MMU-8862456)
Dab2 [lysosomal membrane]
(R-MMU-2980807)
Dab2 [plasma membrane]
(R-MMU-2980808)
0.499
2
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