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AP2B1 [endolysosome membrane]
Stable Identifier
R-HSA-6784827
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endolysosome membrane
Synonyms
AP-2 beta 2
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Internalization of MHC II:Ii clathrin coated vesicle (Homo sapiens)
Clathrin coated MHC class II alpha/beta/Ii nonamer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
AP2B1 [endolysosome membrane] (Homo sapiens)
Uncoating of clathrin-coated vesicles and fusion with endosomes (Homo sapiens)
Clathrin coated MHC class II alpha/beta/Ii nonamer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
AP2B1 [endolysosome membrane] (Homo sapiens)
Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
AP2B1 [endolysosome membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein clearance (Homo sapiens)
LDL clearance (Homo sapiens)
Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Homo sapiens)
Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
AP2B1 [endolysosome membrane] (Homo sapiens)
PCSK9:LDLR:Clathrin:AP2 [endolysosome membrane] (Homo sapiens)
Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
AP2B1 [endolysosome membrane] (Homo sapiens)
PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Homo sapiens)
PCSK9:LDLR:Clathrin:AP2 [endolysosome membrane] (Homo sapiens)
Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
AP2B1 [endolysosome membrane] (Homo sapiens)
VLDLR internalisation and degradation (Homo sapiens)
VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Homo sapiens)
VLDL:PCSK9:Clathrin:AP2 [lysosomal membrane] (Homo sapiens)
Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
AP2B1 [endolysosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P63010 AP2B1
Gene Names
AP2B1, ADTB2, CLAPB1
Chain
initiator methionine:, chain:2-937
Reference Genes
BioGPS Gene:163 AP2B1
COSMIC (genes):AP2B1 AP2B1
CTD Gene:163 AP2B1
dbSNP Gene:163 AP2B1
ENSEMBL:ENSG00000006125 AP2B1
ENSEMBL_homo_sapiens_GENE:ENSG00000006125.18 AP2B1
HGNC:563 AP2B1
KEGG Gene (Homo sapiens):163 AP2B1
Monarch:163 AP2B1
NCBI Gene:163 AP2B1
OMIM:601025 AP2B1
UCSC:P63010 AP2B1
Reference Transcript
RefSeq:XM_005257938.2 AP2B1
RefSeq:NM_001282.2 AP2B1
RefSeq:XM_017024286.1 AP2B1
RefSeq:XM_011524455.2 AP2B1
RefSeq:XM_005257937.3 AP2B1
RefSeq:NM_001030006.1 AP2B1
RefSeq:XM_017024284.1 AP2B1
Other Identifiers
11716261_a_at
11716262_a_at
163
16833345
200612_PM_s_at
200612_s_at
200615_PM_s_at
200615_s_at
36161_at
3718683
3718684
3718686
3718696
3718700
3718703
3718706
3718707
3718708
3718709
3718710
3718712
3718713
3718714
3718715
3718717
3718718
3718721
3718722
3718723
3718724
3718725
3718730
3718732
3718735
3718739
3718740
3718741
4014722
4014723
4014724
4014729
4014731
4014733
4014735
4014738
8006542
A_23_P55149
A_24_P253827
GE57939
GO:0001822
GO:0003279
GO:0003281
GO:0005048
GO:0005515
GO:0005764
GO:0005768
GO:0005773
GO:0005829
GO:0005886
GO:0005905
GO:0006886
GO:0006897
GO:0007507
GO:0009898
GO:0015031
GO:0016020
GO:0016192
GO:0030117
GO:0030122
GO:0030131
GO:0030276
GO:0030666
GO:0030669
GO:0031090
GO:0031410
GO:0035615
GO:0035904
GO:0036020
GO:0043226
GO:0045202
GO:0045334
GO:0048488
GO:0048856
GO:0060090
GO:0060976
GO:0072583
GO:0098793
GO:0098794
GO:0098884
GO:0098978
GO:0099590
HMNXSV003043367
Hs.74626.0.A1_3p_s_at
ILMN_1681998
ILMN_2331735
M34175_at
PH_hs_0024131
TC17000399.hg
g4557468_3p_a_at
Participates
as a component of
Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
Other forms of this molecule
AP2B1 [clathrin-coated endocytic vesicle membrane]
AP2B1 [cytosol]
AP2B1 [plasma membrane]
Inferred To
AP2B1 [endolysosome membrane]
(Bos taurus)
AP2B1 [endolysosome membrane]
(Canis familiaris)
AP2B1 [endolysosome membrane]
(Gallus gallus)
AP2B1 [endolysosome membrane]
(Sus scrofa)
APL1 [endolysosome membrane]
(Saccharomyces cerevisiae)
ap1b1 [endolysosome membrane]
(Dictyostelium discoideum)
apb-1 [endolysosome membrane]
(Caenorhabditis elegans)
apl2 [endolysosome membrane]
(Schizosaccharomyces pombe)
apl1 [endolysosome membrane]
(Schizosaccharomyces pombe)
AP-1-2beta [endolysosome membrane]
(Drosophila melanogaster)
APL2 [endolysosome membrane]
(Saccharomyces cerevisiae)
ap2b1 [endolysosome membrane]
(Danio rerio)
ap2b1 [endolysosome membrane]
(Xenopus tropicalis)
Ap2b1 [endolysosome membrane]
(Mus musculus)
Ap2b1 [endolysosome membrane]
(Rattus norvegicus)
Homologues of AP2B1 [endolysosome membrane]
(Saccharomyces cerevisiae)
Homologues of AP2B1 [endolysosome membrane]
(Schizosaccharomyces pombe)
Cross References
RefSeq
XP_016879773.1
,
NP_001025177.1
,
NP_001273.1
,
XP_005257995.1
,
XP_011522757.1
,
XP_016879775.1
,
XP_005257994.1
OpenTargets
ENSG00000006125
GeneCards
P63010
HPA
ENSG00000006125-AP2B1
Ensembl
ENST00000610402
,
ENST00000618940
,
ENSG00000006125
,
ENSP00000483185
,
ENST00000621914
,
ENSP00000482315
,
ENSP00000482835
PRO
P63010
Pharos - Targets
P63010
PDB
4UQI
,
6YAH
,
7OHO
,
1E42
,
6QH5
,
5M5R
,
2JKR
,
7Z5C
,
6YAE
,
2IV8
,
6YAI
,
7OM8
,
2XA7
,
2VGL
,
2G30
,
6QH7
,
2JKT
,
6QH6
,
6YAF
,
6URI
,
7OG1
,
2IV9
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.809
7
UniProt:Q15811 ITSN1
1
ITSN1 [cytosol]
(R-HSA-3006481)
0.764
5
UniProt:Q5SW96 LDLRAP1
2
LDLRAP1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869097)
LDLRAP1 [plasma membrane]
(R-HSA-171143)
0.681
4
UniProt:P12236 SLC25A6
2
SLC25A6 [mitochondrial inner membrane]
(R-HSA-49745)
SLC25A6 [mitochondrial intermembrane space]
(R-HSA-1955374)
0.666
4
UniProt:Q2M2I8 AAK1
1
AAK1 [cytosol]
(R-HSA-8854795)
0.643
3
UniProt:P42566 EPS15
2
EPS15 [cytosol]
(R-HSA-182920)
p-Y849 EPS15 [cytosol]
(R-HSA-8867028)
0.643
4
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.569
5
UniProt:Q9UHB7 AFF4
1
AFF4 [nucleoplasm]
(R-HSA-8932788)
0.556
3
UniProt:Q99757 TXN2
2
TXN2 [mitochondrial matrix]
(R-HSA-3323048)
2xHC-TXN2 [mitochondrial matrix]
(R-HSA-3323059)
0.556
3
UniProt:P52292 KPNA2
2
KPNA2 [nucleoplasm]
(R-HSA-206045)
KPNA2 [cytosol]
(R-HSA-205976)
0.556
3
UniProt:P49757 NUMB
1
NUMB [plasma membrane]
(R-HSA-443595)
0.527
4
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:Q96D71 REPS1
1
REPS1 [cytosol]
(R-HSA-8862265)
0.527
3
UniProt:Q9UBC2 EPS15L1
2
EPS15L1 [plasma membrane]
(R-HSA-182937)
EPS15L1 [cytosol]
(R-HSA-8935900)
0.527
3
UniProt:P29353 SHC1
5
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
SHC1 [cytosol]
(R-HSA-74680)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
0.527
3
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