Reactome | AP2A1 [endolysosome membrane]

AP2A1 [endolysosome membrane]

Stable Identifier

R-HSA-6784829

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endolysosome membrane

Synonyms

Adaptor protein AP2A1

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - MHC class II antigen presentation (Homo sapiens)
    - Internalization of MHC II:Ii clathrin coated vesicle (Homo sapiens)
      - Clathrin coated MHC class II alpha/beta/Ii nonamer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Homo sapiens)
        
        AP2A1 [endolysosome membrane] (Homo sapiens)
    - Uncoating of clathrin-coated vesicles and fusion with endosomes (Homo sapiens)
      - Clathrin coated MHC class II alpha/beta/Ii nonamer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Homo sapiens)
        
        AP2A1 [endolysosome membrane] (Homo sapiens)
      - Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Homo sapiens)
        
        AP2A1 [endolysosome membrane] (Homo sapiens)

Transport of small molecules (Homo sapiens)

- Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
  - Plasma lipoprotein clearance (Homo sapiens)
    - LDL clearance (Homo sapiens)
      - Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Homo sapiens)
        
        Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Homo sapiens)
        
        AP2A1 [endolysosome membrane] (Homo sapiens)
        
        PCSK9:LDLR:Clathrin:AP2 [endolysosome membrane] (Homo sapiens)
        
        Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Homo sapiens)
        
        AP2A1 [endolysosome membrane] (Homo sapiens)
      - PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Homo sapiens)
        
        PCSK9:LDLR:Clathrin:AP2 [endolysosome membrane] (Homo sapiens)
        
        Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Homo sapiens)
        
        AP2A1 [endolysosome membrane] (Homo sapiens)
    - VLDLR internalisation and degradation (Homo sapiens)
      - VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Homo sapiens)
        
        VLDL:PCSK9:Clathrin:AP2 [lysosomal membrane] (Homo sapiens)
        
        Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Homo sapiens)
        
        AP2A1 [endolysosome membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95782 AP2A1

Gene Names

AP2A1, ADTAA, CLAPA1

Chain

chain:1-977

Reference Genes

BioGPS Gene:160 AP2A1

COSMIC (genes):AP2A1 AP2A1

CTD Gene:160 AP2A1

dbSNP Gene:160 AP2A1

ENSEMBL:ENSG00000196961 AP2A1

ENSEMBL:ENSG00000196961.13 AP2A1

HGNC:561 AP2A1

KEGG Gene (Homo sapiens):160 AP2A1

Monarch:160 AP2A1

NCBI Gene:160 AP2A1

OMIM:601026 AP2A1

UCSC:O95782 AP2A1

Reference Transcript

Other Identifiers

11728299_x_at

11748811_a_at

11752077_a_at

11752078_x_at

160

16864304

223237_3p_x_at

223237_PM_x_at

223237_x_at

229617_3p_x_at

229617_PM_x_at

229617_x_at

234068_PM_s_at

234068_s_at

3838887

3838888

3838891

3838892

3838893

3838894

3838895

3838896

3838897

3838902

3838904

3838905

3838906

3838907

3838908

3838909

3838911

3838912

3838914

3838916

3838918

3838920

3838921

3838922

3838925

3838926

3838927

3838928

3838929

3838931

3838932

3838933

49206_at

8030470

A_14_P132495

A_14_P200554

A_23_P4885

GE54012

GO:0005515

GO:0005764

GO:0005768

GO:0005773

GO:0005794

GO:0005829

GO:0005886

GO:0005905

GO:0005975

GO:0006886

GO:0006895

GO:0006897

GO:0009898

GO:0010976

GO:0015031

GO:0016020

GO:0016192

GO:0016323

GO:0016324

GO:0019901

GO:0030117

GO:0030122

GO:0030130

GO:0030131

GO:0030136

GO:0030154

GO:0030666

GO:0030669

GO:0031410

GO:0032433

GO:0032991

GO:0035615

GO:0036020

GO:0043226

GO:0044877

GO:0045334

GO:0048260

GO:0048856

GO:0050750

GO:0060090

GO:0072583

GO:0098794

GO:0098884

GO:1900126

GO:1901135

HMNXSV003018745

Hs.296426.1.S1_3p_a_at

Hs.296426.1.S1_3p_s_at

ILMN_1673108

ILMN_1815306

ILMN_2359211

PH_hs_0015334

TC19000747.hg

g12053344_3p_s_at

Participates

as a member of

Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Homo sapiens)

Other forms of this molecule

AP2A1 [endocytic vesicle membrane]

AP2A1 [clathrin-coated endocytic vesicle membrane]

AP2A1 [cytosol]

AP2A1 [plasma membrane]

Inferred To

apl3 [endolysosome membrane] (Schizosaccharomyces pombe)

Ap2a1 [endolysosome membrane] (Mus musculus)

Ap2a1 [endolysosome membrane] (Rattus norvegicus)

AP-2alpha [endolysosome membrane] (Drosophila melanogaster)

ap2a1-2 [endolysosome membrane] (Dictyostelium discoideum)

AP2A1 [endolysosome membrane] (Bos taurus)

AP2A1 [endolysosome membrane] (Caenorhabditis elegans)

AP2A1 [endolysosome membrane] (Canis familiaris)

AP2A1 [endolysosome membrane] (Danio rerio)

AP2A1 [endolysosome membrane] (Sus scrofa)

AP2A1 [endolysosome membrane] (Xenopus tropicalis)

APL3 [endolysosome membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_055018.2, NP_570603.2

OpenTargets

ENSG00000196961

GeneCards

O95782

HPA

ENSG00000196961-AP2A1

Ensembl

ENSP00000346246, ENSP00000351926, ENST00000359032, ENST00000354293, ENSG00000196961

PRO

O95782

Pharos - Targets

O95782

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.671	6
UniProt:P29353 SHC1	5	SHC1 [cytosol] (R-HSA-74680) p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y-SHC1 [cytosol] (R-HSA-162568) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321)	0.643	5