Reactome | BPHL hydrolyses VACV to ACV

BPHL hydrolyses VACV to ACV

Stable Identifier

R-HSA-6784959

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, mitochondrial outer membrane

ReviewStatus

5/5

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Valacyclovir (VACV) is the 5'-valyl ester prodrug of acyclovir (ACV), an effective anti-herpetic drug. Systemic bioavailability of ACV in humans is up to five times higher when administered orally as the prodrug. After intestinal absorption, valacyclovir hydrolase (BPHL) mediates the rapid and complete hydrolysis to VACV to ACV (Kim et al. 2003, Lai et al. 2008). The subcellular location of human BPHL is unknown but rat Bhpl localises to the mitochondrial membrane (Kim et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
18256025	Molecular basis of prodrug activation by human valacyclovirase, an alpha-amino acid ester hydrolase Amidon, GL, Lee, KD, Xu, Z, Zhou, J, Lai, L	J. Biol. Chem.	2008
12732646	Identification of a human valacyclovirase: biphenyl hydrolase-like protein as valacyclovir hydrolase Kim, S, Amidon, GL, Lee, KD, Provoda, CJ, Chu, XY, Kim, I	J. Biol. Chem.	2003