Reactome | PTPRJ [plasma membrane]

PTPRJ [plasma membrane]

Stable Identifier

R-HSA-6785269

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Receptor-type tyrosine-protein phosphatase eta, CD148

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q12913 PTPRJ

Gene Names

PTPRJ, DEP1

Chain

signal peptide:1-35, chain:36-1337

Reference Genes

BioGPS Gene:5795 PTPRJ

COSMIC (genes):PTPRJ PTPRJ

CTD Gene:5795 PTPRJ

dbSNP Gene:5795 PTPRJ

ENSEMBL:ENSG00000149177 PTPRJ

ENSEMBL_homo_sapiens_GENE:ENSG00000149177.15 PTPRJ

HGNC:9673 PTPRJ

KEGG Gene (Homo sapiens):5795 PTPRJ

Monarch:5795 PTPRJ

NCBI Gene:5795 PTPRJ

OMIM:600925 PTPRJ

UCSC:Q12913 PTPRJ

Reference Transcript

Other Identifiers

11728971_at

11728972_a_at

11736511_at

11756011_a_at

16724633

1697_s_at

210173_PM_at

210173_at

227396_PM_at

227396_at

3329980

3329984

3329985

3329986

3330038

3330041

3330042

3330043

3330044

3330045

3330046

3330047

3330048

3330050

3330051

3330052

3330053

3330054

3330057

3330058

3330060

3330061

3330064

3330065

3330066

3330068

3330069

3330070

3330071

3330072

3330073

3330074

3330075

3330076

3330077

3330078

3330079

3330080

3330081

3330082

3330083

40583_at

44024_at

5795

73378_at

7939839

A_14_P125829

A_23_P405049

A_24_P921321

A_33_P3309561

D37781_s_at

GE62543

GE852110

GO:0001525

GO:0001772

GO:0002376

GO:0003013

GO:0003824

GO:0004721

GO:0004725

GO:0005161

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0005911

GO:0006470

GO:0007155

GO:0008013

GO:0008285

GO:0009986

GO:0010642

GO:0016020

GO:0016192

GO:0016311

GO:0016787

GO:0016791

GO:0019221

GO:0019901

GO:0023052

GO:0030154

GO:0030155

GO:0030183

GO:0030308

GO:0030336

GO:0031410

GO:0032587

GO:0032760

GO:0034330

GO:0035335

GO:0035579

GO:0035584

GO:0036211

GO:0042059

GO:0042995

GO:0043116

GO:0043226

GO:0043407

GO:0043410

GO:0045295

GO:0045296

GO:0045785

GO:0048008

GO:0048856

GO:0048870

GO:0050731

GO:0050766

GO:0050852

GO:0050860

GO:0050918

GO:0051019

GO:0051894

GO:0051897

GO:0051898

GO:0060242

GO:0060369

GO:0070062

GO:0070097

GO:0070161

GO:0140096

HMNXSV003026351

HMNXSV003044689

Hs.306163.0.A1_3p_at

ILMN_1731589

PH_hs_0010301

TC11000412.hg

TC11002664.hg

U10886_at

g633072_3p_at

Participates

as a member of

Other forms of this molecule

PTPRJ [specific granule membrane]

Inferred To

PTP3 [plasma membrane] (Saccharomyces cerevisiae)

sdf-9 [plasma membrane] (Caenorhabditis elegans)

Homologues of PTPRJ [plasma membrane] (Caenorhabditis elegans)

Homologues of PTPRJ [plasma membrane] (Dictyostelium discoideum)

Homologues of PTPRJ [plasma membrane] (Drosophila melanogaster)

Homologues of PTPRJ [plasma membrane] (Saccharomyces cerevisiae)

Homologues of PTPRJ [plasma membrane] (Schizosaccharomyces pombe)

eak-6 [plasma membrane] (Caenorhabditis elegans)

pyp2 [plasma membrane] (Schizosaccharomyces pombe)

ptpA1-2 [plasma membrane] (Dictyostelium discoideum)

ptpB [plasma membrane] (Dictyostelium discoideum)

pyp3 [plasma membrane] (Schizosaccharomyces pombe)

PTP2 [plasma membrane] (Saccharomyces cerevisiae)

Ptp36E [plasma membrane] (Drosophila melanogaster)

PTP1 [plasma membrane] (Saccharomyces cerevisiae)

dep-1 [plasma membrane] (Caenorhabditis elegans)

pyp1 [plasma membrane] (Schizosaccharomyces pombe)

PTPRJ [plasma membrane] (Bos taurus)

PTPRJ [plasma membrane] (Caenorhabditis elegans)

PTPRJ [plasma membrane] (Canis familiaris)

PTPRJ [plasma membrane] (Drosophila melanogaster)

PTPRJ [plasma membrane] (Gallus gallus)

PTPRJ [plasma membrane] (Mus musculus)

Ptp4E [plasma membrane] (Drosophila melanogaster)

Ptprj [plasma membrane] (Rattus norvegicus)

ptpC [plasma membrane] (Dictyostelium discoideum)

Cross References

RefSeq

NP_002834.3, NP_001091973.1

Guide to Pharmacology - Targets

1858

OpenTargets

ENSG00000149177

IntEnz

3.1.3.48

HPA

ENSG00000149177-PTPRJ

GeneCards

Q12913

Ensembl

ENSP00000400010, ENST00000440289, ENST00000418331, ENSP00000409733, ENSG00000149177

PRO

Q12913

Pharos - Targets

Q12913

HMDB Protein

HMDBP08945

PDB

2CFV, 7U01, 2NZ6, 7U08, 2DLE

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08581 MET	7	p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032) MET [plasma membrane] (R-HSA-419603) p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973)	0.733	5
UniProt:O60716 CTNND1	1	CTNND1 [plasma membrane] (R-HSA-418996)	0.724	5
UniProt:P09619 PDGFRB	3	p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039) PDGFRB [plasma membrane] (R-HSA-186767) p-12Y-PDGFRB [plasma membrane] (R-HSA-186803)	0.715	4
UniProt:P27361 MAPK3	6	MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [nucleoplasm] (R-HSA-73724) MAPK3 [cytosol] (R-HSA-59284) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359)	0.697	5
UniProt:Q12913 PTPRJ	2	PTPRJ [plasma membrane] (R-HSA-6785269) PTPRJ [specific granule membrane] (R-HSA-6799570)	0.658	3
UniProt:P35968 KDR	4	p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane] (R-HSA-9673636) VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane] (R-HSA-9673613) VEGFR2 [plasma membrane] (R-HSA-195382) p-6Y-VEGFR2 [plasma membrane] (R-HSA-4420103)	0.645	4
UniProt:P17948 FLT1	1	VEGFR1 [plasma membrane] (R-HSA-3004464)	0.623	2
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.609	2
UniProt:Q13480 GAB1	4	GAB1 [cytosol] (R-HSA-179795) p-5Y-GAB1 [cytosol] (R-HSA-180344) p-Y627,Y659-GAB1 [cytosol] (R-HSA-180496) p-Y-GAB1 [cytosol] (R-HSA-8855306)	0.609	2
UniProt:P28482 MAPK1	18	MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.578	7
UniProt:O00214 LEG8			0.527	3
UniProt:P17931 LGALS3	3	LGALS3 [ficolin-1-rich granule membrane] (R-HSA-6803307) LGALS3 [plasma membrane] (R-HSA-879445) LGALS3 [secretory granule membrane] (R-HSA-6803327)	0.527	4
UniProt:P0DTC3 3a	9	O-glycosyl 3a [virion membrane] (R-COV-9694395) O-glycosyl 3a [endocytic vesicle membrane] (R-COV-9694729) O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694386) GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694658) 3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694716) 3a [endoplasmic reticulum lumen] (R-COV-9694584) O-glycosyl 3a [endolysosome membrane] (R-COV-9754541) O-glycosyl 3a [plasma membrane] (R-COV-9694433) O-glycosyl 3a [extracellular region] (R-COV-9694387)	0.483	2

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