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PTPRK [plasma membrane]
Stable Identifier
R-HSA-6785699
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Receptor-type protein-tyrosine phosphatase kappa precursor, RPTPk, RPTP kappa
Locations in the PathwayBrowser for interactor UniProt:P04183 TK1
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
EGFR downregulation (Homo sapiens)
Ubiquitination of stimulated EGFR (CBL:GRB2) (Homo sapiens)
PTPRK [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15262 PTPRK
Gene Names
PTPRK, PTPK
Chain
signal peptide:1-26, chain:27-1439
Reference Genes
BioGPS Gene:5796 PTPRK
COSMIC (genes):PTPRK PTPRK
CTD Gene:5796 PTPRK
dbSNP Gene:5796 PTPRK
ENSEMBL:ENSG00000152894 PTPRK
HGNC:9674 PTPRK
KEGG:hsa:5796 PTPRK
Monarch:5796 PTPRK
NCBI Gene:5796 PTPRK
OMIM:602545 PTPRK
UCSC:Q15262 PTPRK
Reference Transcript
RefSeq:NM_001291981.1 PTPRK
RefSeq:NM_001291984.1 PTPRK
RefSeq:NM_001135648.2 PTPRK
RefSeq:NM_002844.3 PTPRK
Other Identifiers
11724273_a_at
11724274_s_at
11749088_s_at
11762135_at
11763595_a_at
1488_at
17023414
203038_PM_at
203038_at
2973377
2973378
2973379
2973380
2973381
2973384
2973385
2973386
2973387
2973389
2973390
2973391
2973392
2973393
2973394
2973395
2973398
2973400
2973401
2973404
2973406
2973407
2973409
2973410
2973411
2973412
2973417
2973418
2973419
2973420
2973421
2973422
2973423
2973424
2973427
2973441
2973442
2973443
2973447
2973448
2973451
2973452
2973453
2973454
2973455
2973457
2973459
2973473
2973474
2973475
2973476
2973482
2973483
2973484
2973486
2973487
2973488
2973492
2973493
2973495
2973496
2973511
2973512
2973513
2973514
2973529
2973551
2973556
2973557
2973559
2973560
2973561
2973562
2973567
5796
59087_r_at
72815_r_at
78129_at
8129418
A_32_P99100
A_33_P3296482
A_33_P3296497
A_33_P3296499
GE81202
GO:0003824
GO:0004721
GO:0004725
GO:0005001
GO:0005515
GO:0005886
GO:0005911
GO:0005912
GO:0006355
GO:0006470
GO:0007155
GO:0007165
GO:0007179
GO:0008013
GO:0008285
GO:0009986
GO:0010839
GO:0016020
GO:0016311
GO:0016477
GO:0016787
GO:0019901
GO:0030054
GO:0030336
GO:0031256
GO:0034330
GO:0034394
GO:0034614
GO:0034644
GO:0043226
GO:0043231
GO:0045295
GO:0045786
GO:0045892
GO:0048041
GO:0048870
GO:0060089
GO:0070161
GO:0140096
HMNXSV003019405
HMNXSV003037266
HMNXSV003037636
HMNXSV003049142
ILMN_1810962
L77886_at
PH_hs_0023965
TC06002092.hg
g4506316_3p_at
This entity regulates
Negatively
Ubiquitination of stimulated EGFR (CBL:GRB2)
(Homo sapiens)
Inferred To
PTPRK [plasma membrane]
(Bos taurus)
PTPRK [plasma membrane]
(Canis familiaris)
PTPRK [plasma membrane]
(Gallus gallus)
PTPRK [plasma membrane]
(Mus musculus)
PTPRK [plasma membrane]
(Sus scrofa)
Cross References
Guide to Pharmacology - Targets
1859
ENSEMBL
ENST00000618924
,
ENSP00000486442
,
ENSP00000484742
,
ENST00000628183
,
ENSP00000357209
,
ENSP00000357198
,
ENST00000532331
,
ENST00000619256
,
ENST00000618215
,
ENSP00000432973
,
ENSP00000357196
,
ENST00000368213
,
ENST00000368226
,
ENST00000368215
,
ENSP00000483766
,
ENSP00000477791
OpenTargets
ENSG00000152894
HPA
ENSG00000152894-PTPRK
PRO
Q15262
Pharos - Targets
Q15262
HMDB Protein
HMDBP08946
PDB
8A1F
,
2C7S
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06213 INSR
6
p-6Y-INSR(763-1382) [endosome membrane]
(R-HSA-141719)
INSR(763-1382) [endosome membrane]
(R-HSA-141722)
INSR(28-758) [endosome membrane]
(R-HSA-141718)
INSR(763-1382) [plasma membrane]
(R-HSA-74669)
p-6Y-INSR(763-1382) [plasma membrane]
(R-HSA-74670)
INSR(28-758) [plasma membrane]
(R-HSA-74668)
0.59
2
UniProt:P28300 LOX
3
LOX(22-168) [extracellular region]
(R-HSA-2022074)
LOX(22-417) [extracellular region]
(R-HSA-2022071)
LOX [extracellular region]
(R-HSA-2022085)
0.581
4
UniProt:P04183 TK1
1
TK1 [cytosol]
(R-HSA-73500)
0.553
2
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