SOCS5 can bind the type I IL4R, reducing its association with JAK1, which results in the inhibition of IL4-mediated STAT6 activation (Seki et al. 2002). Similarly SOCS1 serves as a regulator of IL-4 signaling, diminishing the magnitude and duration of STAT6 activation (Dickensheets et al. 2007).
Matsumoto, A, Kubo, M, Ransom, J, Kishimoto, T, Naka, T, Seki, N, Yoshimura, A, Tsukada, J, Hayashi, K, Seki, Y
Heath, WR, Starr, R, Davey, GM
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