IL4:IL4R:JAK2 binds IL2RG:JAK3

Stable Identifier
R-HSA-6786092
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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IL4:IL4R:JAK2 binds IL2RG:JAK3
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Interleukin 2 receptor gamma subunit (IL2RG), with constitutively-associated Janus kinase 3 (JAK3), binds the IL4:IL4R:JAK2 complex, interacting with IL4 and IL4R to form the ligand-bound type I IL4 receptor complex, IL4R1 (LaPorte et al. 2008).
Literature References
PubMed ID Title Journal Year
18243101 Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system

Keegan, AD, Heller, NM, Qi, X, Vaclavikova, J, Laporte, SL, Juo, ZS, Garcia, KC, Colf, LA

Cell 2008
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Orthologous Events
IL4:IL4R:JAK2 binds IL2RG:JAK3 (Bos taurus)
IL4:IL4R:JAK2 binds IL2RG:JAK3 (Mus musculus)
IL4:IL4R:JAK2 binds IL2RG:JAK3 (Sus scrofa)
Authored
Jupe, S  (2015-07-01)
Reviewed
Leibovich, SJ  (2016-09-02)
Created
Jupe, S  (2015-07-03)
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