JAK1 binds IL4R in IL13-bound IL13R type II

Stable Identifier
R-HSA-6786110
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
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JAK1 binds IL4R in IL13-bound IL13R type II
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In response to Interleukin-13 ( IL13) binding, Janus kinase 1 (JAK1) binds to Interleukin-4 receptor alpha subunit (IL4R) (Roy et al. 2002). IL4R has 2 JAK binding motifs so it is believed that IL4R can bind JAK2 constitutively and additionally bind JAK1 upon ligand binding. The molecular trigger for JAK1 binding is not clear.

Literature References
PubMed ID Title Journal Year
12223527 IL-13 signal transduction in human monocytes: phosphorylation of receptor components, association with Jaks, and phosphorylation/activation of Stats

Roy, B, Ford, D, Maizel, AL, Cathcart, MK, Bhattacharjee, A, Xu, B

J. Leukoc. Biol. 2002
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Authored
Jupe, S  (2015-07-01)
Reviewed
Leibovich, SJ  (2016-09-02)
Created
Jupe, S  (2015-07-03)
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