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IL13 binds IL13RA:TYK2
Stable Identifier
R-HSA-6786118
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
IL13 binds IL13RA:TYK2 (Homo sapiens)
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The type II Interleukin-13 (IL13) receptor complex (IL13R2) forms with IL13 binding to Interleukin-13 receptor alpha subunit 1 (IL13RA1), which is constitutively bound to Non-receptor tyrosine kinase 2 (TYK2), followed by recruitment of Interleukin-4 receptor subunit alpha (IL4R), which is associated with Janus kinase 2 (JAK2) (Wang et al. 2009). IL13RA1 binds IL13 with low affinity (Kd = 2-10 nmol/L) (Miloux et al. 1997).
Literature References
PubMed ID
Title
Journal
Year
9013879
Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex
Lupker, J
,
Laurent, P
,
Vita, N
,
Miloux, B
,
Bonnin, O
,
Caput, D
,
Ferrara, P
FEBS Lett
1997
Participants
Input
IL13 [extracellular region]
(Homo sapiens)
IL13RA1:TYK2 [plasma membrane]
(Homo sapiens)
Output
IL13:IL13RA:TYK2 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Orthologous Events
IL13 binds IL13RA:TYK2 (Bos taurus)
IL13 binds IL13RA:TYK2 (Canis familiaris)
IL13 binds IL13RA:TYK2 (Mus musculus)
IL13 binds IL13RA:TYK2 (Rattus norvegicus)
IL13 binds IL13RA:TYK2 (Sus scrofa)
Authored
Jupe, S (2015-07-01)
Reviewed
Leibovich, SJ (2016-09-02)
Created
Jupe, S (2015-07-03)
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