IL13 binds IL13RA:TYK2

Stable Identifier
R-HSA-6786118
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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IL13 binds IL13RA:TYK2
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The type II Interleukin-13 (IL13) receptor complex (IL13R2) forms with IL13 binding to Interleukin-13 receptor alpha subunit 1 (IL13RA1), which is constitutively bound to Non-receptor tyrosine kinase 2 (TYK2), followed by recruitment of Interleukin-4 receptor subunit alpha (IL4R), which is associated with Janus kinase 2 (JAK2) (Wang et al. 2009). IL13RA1 binds IL13 with low affinity (Kd = 2-10 nmol/L) (Miloux et al. 1997).
Literature References
PubMed ID Title Journal Year
9013879 Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex

Lupker, J, Laurent, P, Vita, N, Miloux, B, Bonnin, O, Caput, D, Ferrara, P

FEBS Lett 1997
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Orthologous Events
IL13 binds IL13RA:TYK2 (Bos taurus)
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IL13 binds IL13RA:TYK2 (Sus scrofa)
Authored
Jupe, S  (2015-07-01)
Reviewed
Leibovich, SJ  (2016-09-02)
Created
Jupe, S  (2015-07-03)
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