Reactome | Translesion synthesis across unhooked ICL by POLN

Translesion synthesis across unhooked ICL by POLN

Stable Identifier

R-HSA-6786166

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

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Translesion synthesis across unhooked ICL by POLN

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The error-prone DNA polymerase nu (POLN) performs translesion DNA synthesis using the DNA strand with unhooked interstrand crosslink (ICL) as a template, thereby bypassing the unhooked ICL (Moldovan et al. 2010, Yamanaka et al. 2010). The DNA strand with unhooked ICL is subsequently repaired via nucleotide excision repair (NER), while the double strand break (DSB) generated by incision of the stalled replication fork during the unhooking step is repaired via homologous recombination repair (HRR) (reviewed by Kottemann and Smogorzewska 2013, Deans and West 2011).

Literature References

PubMed ID	Title	Journal	Year
19995904	DNA polymerase POLN participates in cross-link repair and homologous recombination Moldovan, GL, Madhavan, MV, Vinciguerra, P, McCaffrey, RM, Mirchandani, KD, D'Andrea, AD	Mol. Cell. Biol.	2010
20102227	Novel enzymatic function of DNA polymerase nu in translesion DNA synthesis past major groove DNA-peptide and DNA-DNA cross-links Rizzo, CJ, Kozekov, ID, Lloyd, RS, Wood, RD, Takata, K, Kolbanovskiy, A, Minko, IG, Yamanaka, K	Chem. Res. Toxicol.	2010
21701511	DNA interstrand crosslink repair and cancer West, SC, Deans, AJ	Nat. Rev. Cancer	2011
23325218	Fanconi anaemia and the repair of Watson and Crick DNA crosslinks Kottemann, MC, Smogorzewska, A	Nature	2013