Carboxymethylenebutenolidase homolog (CMBL) is a cytosolic hydrolase enzyme present in liver and intestine. It is able to hydrolyse medoxomil-type pro-drugs to their pharmacologically active metabolites. Olmesartan medoxomil (OM) is an angiotensin II type 1 receptor antagonist widely prescribed as an antihypertensive agent. It is hydrolysed by CMBL to its active metabolite olmesartan (OLMS) (Ishizuka et al 2010). True physiological substrates of CMBL remain unknown.
Ikeda, T, Saito, M, Kurihara, A, Kubota, K, Yoshigae, Y, Fujimori, I, Ishizuka, T, Okazaki, O, Noji-Sakikawa, C, Izumi, T, Kato, M
hydrolase activity of CMBL [cytosol]
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