CARNS1 transforms ATP, L-His, b-Ala to CARN

Stable Identifier
R-HSA-6786245
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CARNS1 transforms ATP, L-His, b-Ala to CARN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Carnosine (beta-alanyl-L-histidine) and homocarnosine (gamma-aminobutyryl-L-histidine) are abundant dipeptides in skeletal muscle and brain of most vertebrates. Carnosine synthase 1 (CARNS1) transforms ATP, L-histidine (L-His) and beta-alanine (b-Ala) to carnosine (CARN) with much greater efficiency than synthesis of homocarnosine (Drozak et al. 2010).
Literature References
PubMed ID Title Journal Year
20097752 Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1)

Stroobant, V, Vertommen, D, Veiga-da-Cunha, M, Drozak, J, Van Schaftingen, E

J. Biol. Chem. 2010
Participants
Input
Output
Participates
as an event of
Catalyst Activity

carnosine synthase activity of CARNS1 [cytosol]

Physical Entity
CARNS1 [cytosol] (Homo sapiens)
Activity
carnosine synthase activity (GO:0047730)
Orthologous Events
CARNS1 transforms ATP, L-His, b-Ala to CARN (Bos taurus)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Canis familiaris)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Gallus gallus)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Mus musculus)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Rattus norvegicus)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Sus scrofa)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2015-07-06)
Reviewed
D'Eustachio, P  (2015-09-14)
Created
Jassal, B  (2015-07-06)
Cite Us!