Reactome | DECR2 reduces LCtE-CoA to t3enoyl-CoA

DECR2 reduces LCtE-CoA to t3enoyl-CoA

Stable Identifier

R-HSA-6786720

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix, peroxisomal membrane

ReviewStatus

5/5

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Saturated and unsaturated fats can undergo beta-oxidation in the mitochondrion and peroxisomes. The only major difference known so far is that peroxisomes can process linear as well as branched unsaturated fatty acid enoyl-CoA esters with much longer chains (>C20) when compared with the mitochondrion. Peroxisomal 2,4-dienoyl-CoA reductase (DECR2) mediates the reduction of long-chain enoyl-CoA esters (LCtE-CoA) to form trans-3-enoyl-CoA esters (t3enoyl-CoA) (De Nys et al. 2001, Hua et al. 2012). DECR2 functions as an auxiliary enzyme for fatty acid beta-oxidation where very long-chain and long-chain fatty acids are shortened in peroxisomes and shuttled to the mitochondrion for complete degradation.

Literature References

PubMed ID	Title	Journal	Year
22745130	Studies of human 2,4-dienoyl CoA reductase shed new light on peroxisomal β-oxidation of unsaturated fatty acids Shaw, N, Wang, J, Liu, ZJ, Wu, D, Hua, T, Ding, W	J. Biol. Chem.	2012
11514237	Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase De Nys, K, Van Veldhoven, PP, Fransen, M, Meyhi, E, Mannaerts, GP	Biochim. Biophys. Acta	2001