Reactome | FUK phosphorylates beta-Fuc to Fuc1P

FUK phosphorylates beta-Fuc to Fuc1P

Stable Identifier

R-HSA-6787540

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        GDP-fucose biosynthesis (Homo sapiens)
        
        FUK phosphorylates beta-Fuc to Fuc1P (Homo sapiens)

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In the GDP-fucose salvage pathway, beta-L-fucose (beta-Fuc) arising from the turnover of glycoproteins and glycolipids in the liver and other tissues is reutilised via a two-step pathway. The first step is the phosphorylation of L-fucose (L-Fuc) to fucose-1-phosphate (Fuc1P) by L-fucose kinase (FUK) (Hinderlich et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
12056818	Identification of human L-fucose kinase amino acid sequence Blume, A, Ghaderi, D, Berger, M, Bauer, C, Chen, H, Hinderlich, S	Biochem. Biophys. Res. Commun.	2002