Reactome | GMDS [cytosol]

GMDS [cytosol]

Stable Identifier

R-HSA-6787620

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

GDP-mannose 4,6 dehydratase ecNumber4.2.1.47/ecNumber, GMDS_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9NWT6 HIF1AN

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        GDP-fucose biosynthesis (Homo sapiens)
        
        GMDS dehydrates GDP-Man to GDP-DHDMan (Homo sapiens)
        
        GMDS [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60547 GMDS

Gene Names

GMDS

Chain

initiator methionine:, chain:2-372

Reference Genes

BioGPS Gene:2762 GMDS

COSMIC (genes):GMDS GMDS

CTD Gene:2762 GMDS

dbSNP Gene:2762 GMDS

ENSEMBL:ENSG00000112699 GMDS

HGNC:4369 GMDS

KEGG:hsa:2762 GMDS

Monarch:2762 GMDS

NCBI Gene:2762 GMDS

OMIM:602884 GMDS

UCSC:O60547 GMDS

Reference Transcript

Other Identifiers

11754571_a_at

17015033

204875_PM_s_at

204875_s_at

214106_PM_s_at

214106_s_at

2762

2938639

2938640

2938641

2938642

2938643

2938644

2938645

2938646

2938647

2938648

2938649

2938662

2938663

2938675

2938678

2938685

2938729

2938730

2938731

2938732

2938738

2938739

2938741

2938742

2938753

2938767

2938771

2938775

2938786

2938799

2938800

2938801

2938802

35071_s_at

74052_at

79560_r_at

8123562

A_23_P72068

A_33_P3413296

GE54369

GE748446

GE869123

GO:0003824

GO:0005515

GO:0005737

GO:0005829

GO:0007219

GO:0008446

GO:0016829

GO:0019673

GO:0042350

GO:0042351

GO:0042802

GO:0043226

GO:0055086

GO:0070062

GO:0070401

GO:1901135

HMNXSV003000954

HMNXSV003001366

HMNXSV003031125

Hs.6487.1.A1_3p_s_at

ILMN_1711227

PH_hs_0005859

TC06001213.hg

g4504030_3p_s_at

Inferred To

GMDS [cytosol] (Bos taurus)

GMDS [cytosol] (Caenorhabditis elegans)

GMDS [cytosol] (Canis familiaris)

GMDS [cytosol] (Dictyostelium discoideum)

GMDS [cytosol] (Drosophila melanogaster)

GMDS [cytosol] (Gallus gallus)

GMDS [cytosol] (Mus musculus)

GMDS [cytosol] (Plasmodium falciparum)

GMDS [cytosol] (Sus scrofa)

Gmds [cytosol] (Rattus norvegicus)

gmds [cytosol] (Xenopus tropicalis)

Cross References

ENSEMBL

ENST00000530927, ENSP00000436726, ENSG00000112699, ENST00000380815, ENSP00000370194

OpenTargets

ENSG00000112699

GeneCards

GMDS

HPA

ENSG00000112699-GMDS

PRO

O60547

Pharos - Targets

O60547

GlyGen

O60547

HMDB Protein

HMDBP00385

PDB

6GPJ, 5IN5, 6Q94, 1T2A, 5IN4, 6GPK, 6GPL

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60547 GMDS	1	GMDS [cytosol] (R-HSA-6787620)	0.8	6
UniProt:Q96HA8 NTAQ1			0.718	6
UniProt:Q9NWT6 HIF1AN	1	HIF1AN [cytosol] (R-HSA-1234154)	0.643	4
UniProt:O43448 KCNAB3	1	KCNAB3 [plasma membrane] (R-HSA-1297367)	0.556	3
UniProt:P38340 NTM1			0.556	3
UniProt:O95271 TNKS	1	TNKS [cytosol] (R-HSA-3640825)	0.527	2
UniProt:Q9H2K2 TNKS2	1	TNKS2 [cytosol] (R-HSA-3640824)	0.527	2

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