HAO2 tetramer oxidises 2OH-PALM

Stable Identifier
R-HSA-6787811
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
Synonyms
2-hydroxyhexadecanoate + O2 => 2-oxohexadecanoate + H2O2
ReviewStatus
5/5
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HAO2 tetramer oxidises 2OH-PALM
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Fatty acids can be metabolised by two distinct pathways; alpha- and beta-oxidation. Peroxisomal hydroxyacid oxidase 2 (HAO2) is thought to take part in alpha-oxidation of long chain fatty acids such as 2-hydroxypalmitate (2OH-PALM). HAO2 functions as a homotetramer and is highly expressed in liver and kidney (Jones et al. 2000).
Literature References
PubMed ID Title Journal Year
10777549 Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases

Jones, JM, Morrell, JC, Gould, SJ

J Biol Chem 2000
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Catalyst Activity

(S)-2-hydroxy-acid oxidase activity of HAO2 tetramer [peroxisomal matrix]

Physical Entity
HAO2 tetramer [peroxisomal matrix] (Homo sapiens)
Activity
(S)-2-hydroxy-acid oxidase activity (GO:0003973)
Orthologous Events
HAO2 tetramer oxidises 2OH-PALM (Bos taurus)
HAO2 tetramer oxidises 2OH-PALM (Caenorhabditis elegans)
HAO2 tetramer oxidises 2OH-PALM (Canis familiaris)
HAO2 tetramer oxidises 2OH-PALM (Drosophila melanogaster)
HAO2 tetramer oxidises 2OH-PALM (Gallus gallus)
HAO2 tetramer oxidises 2OH-PALM (Mus musculus)
HAO2 tetramer oxidises 2OH-PALM (Rattus norvegicus)
HAO2 tetramer oxidises 2OH-PALM (Schizosaccharomyces pombe)
HAO2 tetramer oxidises 2OH-PALM (Sus scrofa)
HAO2 tetramer oxidises 2OH-PALM (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2015-07-17)
Reviewed
D'Eustachio, P  (2015-09-14)
Created
Jassal, B  (2015-07-17)
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