HDHD1:Mg2+ dephosphorylates PURIDP

Stable Identifier
R-HSA-6788295
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Pseudouridine 5'-phosphate (PURIDP) is a potential intermediate in RNA degradation. Pseudouridine 5'-phosphatase (HDHD1) is a Mg2+-dependent enzyme present in erythrocytes that can dephosphorylate PURIDP to pseudouridine (PURID), the fifth-most abundant nucleoside in RNA. PURID is not metabolised in mammals but excreted intact in urine (Preumont et al. 2010).
Literature References
PubMed ID Title Journal Year
20722631 HDHD1, which is often deleted in X-linked ichthyosis, encodes a pseudouridine-5'-phosphatase

Preumont, A, Rzem, R, Vertommen, D, Van Schaftingen, E

Biochem. J. 2010
Participants
Participates
Catalyst Activity

hydrolase activity of HDHD1:Mg2+ [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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