Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
NDUFS8 [mitochondrial matrix]
Stable Identifier
R-HSA-6788526
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
NADH-ubiquinone oxidoreductase 23 kDa subunit
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex I biogenesis (Homo sapiens)
IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
NDUF subunits bind to form the IP subcomplex (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
NUBPL transfers 4Fe-4S to Complex I subunits (Homo sapiens)
NDUF subunits [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
NDUF:4Fe-4S subunits [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00217 NDUFS8
Gene Names
NDUFS8
Chain
transit peptide:1-34, chain:35-210
Reference Genes
BioGPS Gene:4728 NDUFS8
COSMIC (genes):NDUFS8 NDUFS8
CTD Gene:4728 NDUFS8
dbSNP Gene:4728 NDUFS8
ENSEMBL:ENSG00000110717 NDUFS8
ENSEMBL_homo_sapiens_GENE:ENSG00000110717.13 NDUFS8
HGNC:7715 NDUFS8
KEGG Gene (Homo sapiens):4728 NDUFS8
Monarch:4728 NDUFS8
NCBI Gene:4728 NDUFS8
OMIM:602141 NDUFS8
UCSC:O00217 NDUFS8
Reference Transcript
RefSeq:XM_005274014.2 NDUFS8
RefSeq:NM_002496.3 NDUFS8
RefSeq:XM_005274013.1 NDUFS8
RefSeq:XM_011545053.2 NDUFS8
Other Identifiers
11722194_a_at
203189_PM_s_at
203189_s_at
203190_PM_at
203190_at
3337361
3337367
3337370
3337375
3337377
3337383
3337385
3337386
38257_at
4728
58954_at
7941976
A_23_P86774
A_33_P3213463
GE54322
GO:0003824
GO:0003954
GO:0005215
GO:0005515
GO:0005739
GO:0005743
GO:0005747
GO:0005759
GO:0006091
GO:0006120
GO:0006979
GO:0007005
GO:0008137
GO:0009060
GO:0016020
GO:0016491
GO:0016651
GO:0032981
GO:0042776
GO:0043226
GO:0046872
GO:0051536
GO:0051539
GO:0055086
GO:0065003
GO:0070469
GO:1901135
HMNXSV003005843
ILMN_1794132
PH_hs_0005049
TC11000703.hg
U65579_at
g4505370_3p_at
Participates
as a member of
NDUF subunits [mitochondrial matrix] (Homo sapiens)
as a component of
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
Inferred To
NDUFS8 [mitochondrial matrix]
(Bos taurus)
NDUFS8 [mitochondrial matrix]
(Caenorhabditis elegans)
NDUFS8 [mitochondrial matrix]
(Canis familiaris)
NDUFS8 [mitochondrial matrix]
(Drosophila melanogaster)
NDUFS8 [mitochondrial matrix]
(Gallus gallus)
NDUFS8 [mitochondrial matrix]
(Mus musculus)
NDUFS8 [mitochondrial matrix]
(Sus scrofa)
ndufs8 [mitochondrial matrix]
(Danio rerio)
ndufs8 [mitochondrial matrix]
(Dictyostelium discoideum)
ndufs8 [mitochondrial matrix]
(Xenopus tropicalis)
Ndufs8 [mitochondrial matrix]
(Rattus norvegicus)
Cross References
RefSeq
XP_005274071.1
,
XP_005274070.1
,
NP_002487.1
,
XP_011543355.1
OpenTargets
ENSG00000110717
IntEnz
7.1.1.2
HPA
ENSG00000110717-NDUFS8
GeneCards
O00217
Ensembl
ENSG00000110717
,
ENST00000313468
,
ENSP00000315774
PRO
O00217
Pharos - Targets
O00217
Orphanet
16532
HMDB Protein
HMDBP00152
PDB
5XTB
,
5XTH
,
5XTI
,
5XTD
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75489 NDUFS3
2
NDUFS3 [mitochondrial matrix]
(R-HSA-163927)
NDUFS3 [cytosol]
(R-HSA-9714751)
0.643
6
UniProt:O75380 NDUFS6
1
NDUFS6 [mitochondrial inner membrane]
(R-HSA-163922)
0.527
2
UniProt:Q8IWL3 HSCB
5
HSCB [mitochondrial matrix]
(R-HSA-1299438)
HSCB [mitochondrial inner membrane]
(R-HSA-1299447)
HSCB(1-235) [mitochondrial inner membrane]
(R-HSA-1299443)
HSCB(1-30) [mitochondrial matrix]
(R-HSA-8986120)
HSCB(1-235) [mitochondrial intermembrane space]
(R-HSA-1299456)
0.462
6
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text