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NDUFS8 [mitochondrial matrix]
Stable Identifier
R-HSA-6788526
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
NADH-ubiquinone oxidoreductase 23 kDa subunit
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex I biogenesis (Homo sapiens)
IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
NDUF subunits bind to form the IP subcomplex (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
NUBPL transfers 4Fe-4S to Complex I subunits (Homo sapiens)
NDUF subunits [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
NDUF:4Fe-4S subunits [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8 [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00217 NDUFS8
Gene Names
NDUFS8
Chain
transit peptide:1-34, chain:35-210
Reference Genes
BioGPS Gene:4728 NDUFS8
COSMIC (genes):NDUFS8 NDUFS8
CTD Gene:4728 NDUFS8
dbSNP Gene:4728 NDUFS8
ENSEMBL:ENSG00000110717 NDUFS8
HGNC:7715 NDUFS8
KEGG:hsa:4728 NDUFS8
Monarch:4728 NDUFS8
NCBI Gene:4728 NDUFS8
OMIM:602141 NDUFS8
UCSC:O00217 NDUFS8
Reference Transcript
RefSeq:XM_011545053.2 NDUFS8
RefSeq:XM_005274013.1 NDUFS8
RefSeq:NM_002496.3 NDUFS8
RefSeq:XM_005274014.2 NDUFS8
Other Identifiers
11722194_a_at
11761157_a_at
16727995
17118798
203189_PM_s_at
203189_s_at
203190_PM_at
203190_at
232169_PM_x_at
232169_x_at
3337361
3337362
3337363
3337364
3337366
3337367
3337368
3337369
3337370
3337371
3337372
3337373
3337374
3337375
3337376
3337377
3337378
3337379
3337380
3337381
3337382
3337383
3337384
3337385
3337386
38257_at
4728
58954_at
7941976
79643_at
A_14_P100794
A_23_P86774
A_33_P3213463
GE54322
GO:0003824
GO:0003954
GO:0005215
GO:0005515
GO:0005739
GO:0005743
GO:0005759
GO:0006091
GO:0006120
GO:0008137
GO:0009060
GO:0016020
GO:0016491
GO:0016651
GO:0032981
GO:0042776
GO:0043226
GO:0045271
GO:0046872
GO:0051539
GO:0055085
GO:0055086
GO:0065003
GO:1901135
GO:1902600
HMNXSV003005843
HMNXSV003031273
HMNXSV003042975
Hs.90443.1.A1_3p_x_at
ILMN_1794132
PH_hs_0005049
PH_hs_0035485
TC11000703.hg
U65579_at
g4505370_3p_at
Participates
as a member of
NDUF subunits [mitochondrial matrix] (Homo sapiens)
as a component of
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
Inferred To
NDUFS8 [mitochondrial matrix]
(Bos taurus)
NDUFS8 [mitochondrial matrix]
(Caenorhabditis elegans)
NDUFS8 [mitochondrial matrix]
(Canis familiaris)
NDUFS8 [mitochondrial matrix]
(Drosophila melanogaster)
NDUFS8 [mitochondrial matrix]
(Gallus gallus)
NDUFS8 [mitochondrial matrix]
(Mus musculus)
NDUFS8 [mitochondrial matrix]
(Sus scrofa)
ndufs8 [mitochondrial matrix]
(Dictyostelium discoideum)
ndufs8 [mitochondrial matrix]
(Xenopus tropicalis)
Ndufs8 [mitochondrial matrix]
(Rattus norvegicus)
ndufs8a [mitochondrial matrix]
(Danio rerio)
Cross References
ENSEMBL
ENST00000313468
,
ENSP00000315774
OpenTargets
ENSG00000110717
IntEnz
7.1.1.2
HPA
ENSG00000110717-NDUFS8
PRO
O00217
Pharos - Targets
O00217
GlyGen
O00217
Orphanet
NDUFS8
HMDB Protein
HMDBP00152
PDB
5XTB
,
5XTI
,
5XTD
,
5XTH
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75489 NDUFS3
2
NDUFS3 [mitochondrial matrix]
(R-HSA-163927)
NDUFS3 [cytosol]
(R-HSA-9714751)
0.725
7
UniProt:O75380 NDUFS6
1
NDUFS6 [mitochondrial inner membrane]
(R-HSA-163922)
0.643
5
UniProt:Q9NPL8 TIMMDC1
1
TIMMDC1 [mitochondrial inner membrane]
(R-HSA-5689720)
0.527
2
UniProt:Q9P032 NDUFAF4
1
NDUFAF4 [mitochondrial inner membrane]
(R-HSA-5689124)
0.527
5
UniProt:Q9BQ95 ECSIT
2
ECSIT [cytosol]
(R-HSA-168064)
ECSIT [mitochondrial inner membrane]
(R-HSA-5689047)
0.527
2
UniProt:O43920 NDUFS5
1
NDUFS5 [mitochondrial inner membrane]
(R-HSA-60226)
0.527
2
UniProt:Q9P0J0 NDUFA13
8
NDUFA13 [mitochondrial inner membrane]
(R-HSA-59936)
NDUFA13(41-49) [mitochondrial inner membrane]
(R-HSA-9839958)
NDUFA13(100-108) [mitochondrial inner membrane]
(R-HSA-9839959)
NDUFA13(109-144) [mitochondrial inner membrane]
(R-HSA-9839968)
NDUFA13(2-19) [mitochondrial inner membrane]
(R-HSA-9839966)
NDUFA13(69-99) [mitochondrial inner membrane]
(R-HSA-9839964)
NDUFA13(20-40) [mitochondrial inner membrane]
(R-HSA-9839963)
NDUFA13(50-68) [mitochondrial inner membrane]
(R-HSA-9839961)
0.527
3
UniProt:Q8IWL3 HSCB
5
HSCB [mitochondrial matrix]
(R-HSA-1299438)
HSCB(1-30) [mitochondrial matrix]
(R-HSA-8986120)
HSCB(1-235) [mitochondrial inner membrane]
(R-HSA-1299443)
HSCB [mitochondrial inner membrane]
(R-HSA-1299447)
HSCB(1-235) [mitochondrial intermembrane space]
(R-HSA-1299456)
0.462
6
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