Reactome | p-Y701-STAT1 [nucleoplasm]

p-Y701-STAT1 [nucleoplasm]

Stable Identifier

R-HSA-6788624

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Signal transducer and activator of transcription 1-alpha/beta, STAT1_HUMAN

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External Reference Information

External Reference

UniProt:P42224 STAT1

Gene Names

STAT1

Chain

initiator methionine:, chain:2-750

Reference Genes

BioGPS Gene:6772 STAT1

COSMIC (genes):STAT1 STAT1

CTD Gene:6772 STAT1

dbSNP Gene:6772 STAT1

ENSEMBL:ENSG00000115415 STAT1

ENSEMBL_homo_sapiens_GENE:ENSG00000115415.21 STAT1

HGNC:11362 STAT1

KEGG Gene (Homo sapiens):6772 STAT1

Monarch:6772 STAT1

NCBI Gene:6772 STAT1

OMIM:600555 STAT1

UCSC:P42224 STAT1

Reference Transcript

Other Identifiers

11726689_a_at

11726690_a_at

11743353_s_at

16906534

200887_PM_s_at

200887_s_at

209969_PM_s_at

209969_s_at

2592269

2592271

2592272

2592273

2592274

2592275

2592276

2592279

2592281

2592282

2592283

2592284

2592286

2592289

2592292

2592294

2592296

2592298

2592299

2592300

2592303

2592304

2592306

2592309

2592310

2592317

2592318

2592319

2592320

2592321

2592324

2592325

2592326

2592327

2592329

2592330

2592331

2592332

32859_at

32860_g_at

33338_at

33339_g_at

6772

8057744

AFFX-HUMISGF3A/M97935_3_at

AFFX-HUMISGF3A/M97935_5_at

AFFX-HUMISGF3A/M97935_MA_at

AFFX-HUMISGF3A/M97935_MB_at

A_23_P56630

A_24_P274270

GE58182

GO:0000122

GO:0000785

GO:0000977

GO:0000978

GO:0000979

GO:0000981

GO:0001222

GO:0001223

GO:0001937

GO:0002053

GO:0002230

GO:0002376

GO:0003013

GO:0003340

GO:0003677

GO:0003690

GO:0003700

GO:0005164

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006952

GO:0007165

GO:0007166

GO:0007259

GO:0007584

GO:0008015

GO:0008284

GO:0009410

GO:0009612

GO:0010742

GO:0012501

GO:0014070

GO:0016525

GO:0016922

GO:0019899

GO:0023052

GO:0030154

GO:0030424

GO:0030425

GO:0031730

GO:0032727

GO:0032869

GO:0032991

GO:0033209

GO:0034097

GO:0034341

GO:0035035

GO:0035456

GO:0035458

GO:0038113

GO:0042127

GO:0042393

GO:0042542

GO:0042802

GO:0042803

GO:0042981

GO:0043124

GO:0043226

GO:0043434

GO:0043565

GO:0044389

GO:0045296

GO:0045648

GO:0045893

GO:0045944

GO:0046725

GO:0048471

GO:0048661

GO:0048856

GO:0051591

GO:0051607

GO:0051721

GO:0051770

GO:0060333

GO:0060337

GO:0061326

GO:0070106

GO:0070721

GO:0071310

GO:0071345

GO:0071346

GO:0071407

GO:0072136

GO:0072162

GO:0072308

GO:0090575

GO:0098542

GO:0140110

GO:1990841

HMNXSV003020843

HMNXSV003045718

ILMN_1691364

ILMN_1777325

M97935_s_at

M97936_at

PH_hs_0001863

TC02002624.hg

g12803734_3p_a_at

g6274551_3p_s_at

Participates

as a component of

Other forms of this molecule

p-STAT1 [nucleoplasm]

p-STAT1 [cytosol]

p-Y701,S727-STAT1 [cytosol]

p-Y701-STAT1 [nucleoplasm]

p-Y701-STAT1 [cytosol]

STAT1 [cytosol]

Inferred To

Homologues of p-Y701-STAT1 [nucleoplasm] (Dictyostelium discoideum)

phospho-sta-2 [nucleoplasm] (Caenorhabditis elegans)

phospho-stat1a [nucleoplasm] (Danio rerio)

phospho-sta-1 [nucleoplasm] (Caenorhabditis elegans)

phospho-Stat1 [nucleoplasm] (Mus musculus)

phospho-Stat1 [nucleoplasm] (Rattus norvegicus)

phospho-dstD [nucleoplasm] (Dictyostelium discoideum)

phospho-p-Y701-STAT1-1 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-Y701-STAT1-1 [nucleoplasm] (Gallus gallus)

phospho-dstC [nucleoplasm] (Dictyostelium discoideum)

phospho-Stat92E [nucleoplasm] (Drosophila melanogaster)

Homologues of p-Y701-STAT1-1 [nucleoplasm] (Caenorhabditis elegans)

phospho-dstB [nucleoplasm] (Dictyostelium discoideum)

phospho-p-Y701-STAT1 [nucleoplasm] (Dictyostelium discoideum)

phospho-dstA [nucleoplasm] (Dictyostelium discoideum)

phospho-STAT1 [nucleoplasm] (Bos taurus)

phospho-STAT1 [nucleoplasm] (Canis familiaris)

phospho-STAT1 [nucleoplasm] (Sus scrofa)

phospho-stat1 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 701

Coordinate

701

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_006712781.1, NP_644671.1, NP_009330.1

OpenTargets

ENSG00000115415

ZINC - Substances

STAT1_HUMAN

ZINC target

P42224

ZINC - Biogenic

STAT1_HUMAN

PRO

P42224

PDB

1YVL, 8D3F, 1BF5, 7NUF, 2KA6, 3WWT

ZINC - Investigational

STAT1_HUMAN

ZINC - Metabolites

STAT1_HUMAN

GeneCards

P42224

HPA

ENSG00000115415-STAT1

Ensembl

ENST00000409465, ENST00000540176, ENSP00000354394, ENSP00000376136, ENST00000392322, ENST00000361099, ENST00000674080, ENSP00000501225, ENSP00000438703, ENST00000673841, ENSP00000386244, ENST00000415035, ENSP00000388240, ENST00000392323, ENSP00000376137, ENSG00000115415, ENSP00000501164, ENSP00000513582, ENST00000698141

Pharos - Targets

P42224

Orphanet

15563

ZINC - Predictions - Purchasable

STAT1_HUMAN

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52630 STAT2	4	p-Y690-STAT2 [cytosol] (R-HSA-909683) STAT2 [cytosol] (R-HSA-882029) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673) p-Y-STAT2 [cytosol] (R-HSA-8987235)	0.92	19
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.908	10
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.774	7
UniProt:P23458 JAK1	6	p-Y1034,Y1035-JAK1 [cytosol] (R-HSA-9005335) JAK1 [endosome] (R-HSA-8983168) p-JAK1 [cytosol] (R-HSA-8950711) p-Y1034-JAK1 [cytosol] (R-HSA-1112543) JAK1 [cytosol] (R-HSA-451898) p-Y-JAK1 [cytosol] (R-HSA-451921)	0.757	6
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.706	6
UniProt:P15260 IFNGR1	2	IFNGR1 [plasma membrane] (R-HSA-629623) p-Y457-IFNGR1 [plasma membrane] (R-HSA-873798)	0.69	4
IntAct:EBI-9984951 IRF1			0.669	3
UniProt:Q8N9N8 EIF1A			0.666	4
UniProt:P42224 STAT1	8	p-STAT1 [nucleoplasm] (R-HSA-8987140) p-STAT1 [cytosol] (R-HSA-8950418) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [cytosol] (R-HSA-3132766) STAT1 [cytosol] (R-HSA-629622)	0.643	4
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.623	4
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.576	3
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.571	3
UniProt:Q01804 OTUD4			0.556	3
IntAct:EBI-10178797 4005			0.556	3
UniProt:Q13813 SPTAN1	6	SPTAN1 [cytosol] (R-HSA-201601) SPTAN1(1-1185) [cytosol] (R-HSA-202944) SPTAN1(1186-2472) [cytosol] (R-HSA-202964) SPTAN1 [tertiary granule lumen] (R-HSA-6800874) SPTAN1 [extracellular region] (R-HSA-6806322) SPTAN1 [specific granule lumen] (R-HSA-6799533)	0.547	2
UniProt:P03255-2			0.544	2
UniProt:P07239 DUSP			0.544	2
UniProt:Q14765 STAT4	4	p-Y693-STAT4 [nucleoplasm] (R-HSA-8950636) p-STAT4 [cytosol] (R-HSA-8950350) p-Y693-STAT4 [cytosol] (R-HSA-8950343) STAT4 [cytosol] (R-HSA-8950606)	0.536	2
UniProt:Q05397 PTK2	11	pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.536	3
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.536	6
UniProt:P10276 RARA	3	SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) RARA [nucleoplasm] (R-HSA-446164)	0.532	4
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3
UniProt:Q77M19 Q77M19			0.527	4
UniProt:Q997F2 V			0.527	2
UniProt:P0C1C7 W			0.527	2
UniProt:Q00978 IRF9	2	IRF9 [nucleoplasm] (R-HSA-913522) IRF9 [cytosol] (R-HSA-879183)	0.527	3
UniProt:P26664 POLG			0.524	5
IntAct:EBI-10097350 STAT			0.524	2
UniProt:Q4VW77 Q4VW77			0.524	2
UniProt:Q01094 E2F1	2	E2F1 [nucleoplasm] (R-HSA-68639) p-E2F1 [nucleoplasm] (R-HSA-187911)	0.524	2
UniProt:P03255-1			0.508	2
UniProt:P19793 RXRA	4	RXRA [cytosol] (R-HSA-9619757) p-S21-RXRA [nucleoplasm] (R-HSA-5334811) monoSUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) RXRA [nucleoplasm] (R-HSA-381319)	0.508	2
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.508	2
UniProt:P17181 IFNAR1	2	IFNAR1 [plasma membrane] (R-HSA-877334) p-Y466,Y481-IFNAR1 [plasma membrane] (R-HSA-909675)	0.499	2
UniProt:P48551 IFNAR2			0.499	2
IntAct:EBI-9825772 C-FOS PROMOTER REGION			0.499	3
IntAct:EBI-10097414 FOXP3			0.499	2
UniProt:P11277 SPTB	1	SPTB [cytosol] (R-HSA-391565)	0.488	2
UniProt:P27958-PRO_0000037576			0.463	4
UniProt:Q9UIV1 CNOT7	1	CNOT7 [cytosol] (R-HSA-429877)	0.463	2

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