Myeloperoxidase (MPO) binds to the bacterial cell surface

Stable Identifier
Reaction [omitted]
Homo sapiens
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Association of MPO with the surfaces of ingested bacteria has been observed microscopically (Selvaraj RJ et al. 1978). This could be a way of directing HOCl for effective killing (Klebanoff SJ et al. 1999). MPO has been shown to bind to the surface of a number of species (Miyasaki KT et al. 1987). However, even with MPO binding, most of the H2O2 would react with unbound MPO.

Literature References
PubMed ID Title Journal Year
10519157 Myeloperoxidase

Klebanoff, SJ

Proc. Assoc. Am. Physicians 1999
206633 Enhanced killing of myeloperoxidase-coated bacteria in the myeloperoxidase-H2O2-Cl- system

Selvaraj, RJ, Paul, BB, Zgliczynski, JM, Sbarra, AJ

J. Infect. Dis. 1978
3032796 Role of high-avidity binding of human neutrophil myeloperoxidase in the killing of Actinobacillus actinomycetemcomitans

Wilson, ME, Zambon, JJ, Miyasaki, KT, Jones, CA

Infect. Immun. 1987
17074761 Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome: implications for microbial killing

Hampton, MB, Livesey, JH, Kettle, AJ, Winterbourn, CC

J. Biol. Chem. 2006
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