Expression of NDN,TP53

Stable Identifier
R-HSA-6789960
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Signal transducer and activator of transcription 3 (STAT3) is a key regulator of gene expression in response to signaling of many cytokines including interleukin-6 (IL6), Oncostatin M, and leukemia inhibitory factor. Using microarray techniques, hundreds of genes have been reported as potential STAT3 target genes (Dauer et al. 2005, Hsieh et al. 2005). Some of these genes have been proven to be direct STAT3 targets using genome-wide chromatin immunoprecipitation screening (Snyder et al. 2008, Carpenter & Lo 2014). Genes encoding nuclear proteins that are downregulated by STAT3 include Necdin (NDN) (Haviland et al. 2011) and Cellular tumor antigen p53 (TP53) (Niu et al. 2005).
Literature References
PubMed ID Title Journal Year
16107692 Role of Stat3 in regulating p53 expression and function

Cress, WD, Briggs, J, Karras, J, Yu, H, Wright, GM, Huang, M, Niu, G, Pardoll, D, Irby, R, Ma, Y, Jove, R, Wright, KL, Chen, J

Mol. Cell. Biol. 2005
22046235 Necdin, a negative growth regulator, is a novel STAT3 target gene down-regulated in human cancer

Cress, WD, Ma, Y, Jove, R, Bloom, G, Minton, S, Eschrich, S, Haviland, R

PLoS ONE 2011
Participants
Participates
This event is regulated
Authored
Reviewed
Created
Cite Us!