Reactome | RPS6 [nucleoplasm]

RPS6 [nucleoplasm]

Stable Identifier

R-HSA-6790606

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

40S ribosomal protein S6, RS6_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P62753 RPS6

Gene Names

RPS6, OK/SW-cl.2

Chain

chain:1-249

Reference Genes

BioGPS Gene:6194 RPS6

COSMIC (genes):RPS6 RPS6

CTD Gene:6194 RPS6

dbSNP Gene:6194 RPS6

ENSEMBL:ENSG00000137154 RPS6

ENSEMBL:ENSG00000137154.13 RPS6

HGNC:10429 RPS6

KEGG Gene (Homo sapiens):6194 RPS6

Monarch:6194 RPS6

NCBI Gene:6194 RPS6

OMIM:180460 RPS6

UCSC:P62753 RPS6

Reference Transcript

RefSeq:NM_001010.2 RPS6

Other Identifiers

11719464_x_at

11763007_x_at

17092737

18670421

18670422

18670423

18670425

18670426

18670429

18670432

200081_PM_s_at

200081_s_at

201254_PM_x_at

201254_x_at

209134_PM_s_at

209134_s_at

3200714

3200715

3200716

3200718

3200719

3200724

3200725

3200726

3200728

3200733

35125_at

3822012

4012811

6194

8160308

91667_at

A_23_P123563

GO:0000082

GO:0000278

GO:0001890

GO:0002181

GO:0002309

GO:0002376

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005783

GO:0005829

GO:0005840

GO:0005844

GO:0006364

GO:0006412

GO:0006924

GO:0007369

GO:0008284

GO:0012501

GO:0015935

GO:0016020

GO:0019901

GO:0022414

GO:0022605

GO:0022626

GO:0022627

GO:0023052

GO:0030154

GO:0030425

GO:0031929

GO:0032040

GO:0033077

GO:0036464

GO:0042254

GO:0042274

GO:0042593

GO:0043065

GO:0043066

GO:0043226

GO:0044297

GO:0048471

GO:0048821

GO:0048856

GO:0110165

GO:1990904

HMNXSV003054392

ILMN_1656791

ILMN_1808939

M77232_rna1_at

PH_hs_0030081

PH_hs_0039702

TC09000936.hg

TC09000938.hg

g12751054_3p_s_at

Participates

as a component of

This entity regulates

Positively

30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)

Other forms of this molecule

3OHR147-RPS6 [cytosol]

p-5S-RPS6 [cytosol]

RPS6 [cytosol]

Inferred To

RpS6 [nucleoplasm] (Drosophila melanogaster)

wu:fa92e06 [nucleoplasm] (Danio rerio)

rps-6 [nucleoplasm] (Caenorhabditis elegans)

Rps6 [nucleoplasm] (Mus musculus)

Rps6 [nucleoplasm] (Rattus norvegicus)

rps602 [nucleoplasm] (Schizosaccharomyces pombe)

Homologues of RPS6 [nucleoplasm] (Saccharomyces cerevisiae)

rps6 [nucleoplasm] (Dictyostelium discoideum)

rps6 [nucleoplasm] (Xenopus tropicalis)

RPS6 [nucleoplasm] (Bos taurus)

RPS6 [nucleoplasm] (Canis familiaris)

RPS6 [nucleoplasm] (Gallus gallus)

RPS6 [nucleoplasm] (Plasmodium falciparum)

RPS6B [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of RPS6 [nucleoplasm] (Sus scrofa)

RPS6A [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001001.2

OpenTargets

ENSG00000137154

HPA

ENSG00000137154-RPS6

GeneCards

P62753

Ensembl

ENSP00000369757, ENST00000380394, ENSG00000137154

PRO

P62753

Pharos - Targets

P62753

PDB

6FEC, 7WTZ, 6ZUO, 6IP5, 6ZMI, 7WU0, 6F4P, 7WTX, 7QVP, 6ZN5, 6XA1, 6OLG, 6F4Q, 6ZVJ, 4UG0, 7R4X, 7WTU, 7TQL, 4V6X, 7MQA, 6ZVH, 6G53, 6Z6N, 6ZOJ, 6Z6M, 6G4S, 6IP6, 6OLZ, 5T2C, 6ZMO, 6Y2L, 7WTS, 6ZV6, 6IP8, 6G18, 6OM7, 7MQ9, 5A2Q, 6Z6L, 7QP7, 7WTT, 7MQ8, 6G5H, 6ZXF, 6Y0G, 5OA3, 6OLI, 6ZXE, 7QP6, 6QZP, 6ZP4, 6OM0, 6ZME, 5VYC, 6ZXD, 6ZOK, 5AJ0, 6ZON, 7A09, 6OLE, 6OLF, 7K5I, 7WTW, 6ZMT, 6G4W, 5FLX, 7ZJW, 6ZLW, 6ZM7, 7WTV, 6ZMW, 7ZJX, 6ZXH, 6G5I, 5LKS, 6ZXG, 6Y57, 6YBW, 6G51

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.702	6
UniProt:O95793 STAU1			0.7	5
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.65	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.576	3
UniProt:Q14684 RRP1B			0.569	3
UniProt:Q96RG2 PASK			0.558	3
UniProt:P0DTD1-PRO_0000449619 REP			0.528	3
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.527	2
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.495	2
UniProt:Q15397 PUM3			0.483	2
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.483	3
UniProt:O00567 NOP56	2	NOP56 [nucleoplasm] (R-HSA-6790696) NOP56 [cytosol] (R-HSA-391293)	0.483	2
UniProt:Q5C9Z4 NOM1			0.483	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	10
UniProt:Q00005 2ABB			0.462	2
UniProt:Q9BRP8 PYM1			0.462	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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