Reactome | RPS14 [nucleoplasm]

RPS14 [nucleoplasm]

Stable Identifier

R-HSA-6790669

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

40S ribosomal protein S14, RS14_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q00005 2ABB

Expand all

External Reference Information

External Reference

UniProt:P62263 RPS14

Gene Names

RPS14, PRO2640

Chain

initiator methionine:, chain:2-151

Reference Genes

BioGPS Gene:6208 RPS14

COSMIC (genes):RPS14 RPS14

CTD Gene:6208 RPS14

dbSNP Gene:6208 RPS14

ENSEMBL:ENSG00000164587 RPS14

ENSEMBL_homo_sapiens_GENE:ENSG00000164587.13 RPS14

HGNC:10387 RPS14

KEGG Gene (Homo sapiens):6208 RPS14

Monarch:6208 RPS14

NCBI Gene:6208 RPS14

OMIM:130620 RPS14

UCSC:P62263 RPS14

Reference Transcript

Other Identifiers

11715540_s_at

11725714_a_at

11725715_x_at

17001674

208645_3p_s_at

208645_PM_s_at

208645_s_at

208646_PM_at

208646_at

2323749

2881414

2881415

2881416

2881417

2881421

2881423

2881426

2881428

2881429

2881430

2881431

32412_at

6208

8115158

A_23_P81492

A_24_P37939

GE80130

GE86729

GO:0000028

GO:0000122

GO:0002181

GO:0002376

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0005840

GO:0005925

GO:0006351

GO:0006355

GO:0006412

GO:0006417

GO:0014069

GO:0015935

GO:0016020

GO:0022626

GO:0022627

GO:0030154

GO:0030218

GO:0030490

GO:0032040

GO:0042254

GO:0042274

GO:0043226

GO:0045182

GO:0045202

GO:0048027

GO:0048856

GO:0065003

GO:0070062

GO:1990904

HMNXSV003039360

HMNXSV003046014

HMNXSV003053506

Hs.244621.3.S1_3p_at

ILMN_1666635

ILMN_2338785

M13934_cds2_at

TC05001937.hg

TC05003306.hg

g7959918_3p_a_at

g7959918_3p_at

g7959918_3p_x_at

Participates

as a component of

This entity regulates

Positively

30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)

Other forms of this molecule

RPS14 [cytosol]

Inferred To

RPS14B [nucleoplasm] (Saccharomyces cerevisiae)

rps1402 [nucleoplasm] (Schizosaccharomyces pombe)

Homologues of RPS14 [nucleoplasm] (Schizosaccharomyces pombe)

RPS14 [nucleoplasm] (Bos taurus)

RPS14 [nucleoplasm] (Canis familiaris)

RPS14 [nucleoplasm] (Gallus gallus)

RPS14 [nucleoplasm] (Sus scrofa)

Ghost homologue of RPS14 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of RPS14 [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of RPS14 [nucleoplasm] (Xenopus tropicalis)

rps14 [nucleoplasm] (Danio rerio)

rps14 [nucleoplasm] (Dictyostelium discoideum)

Rps14 [nucleoplasm] (Mus musculus)

Rps14 [nucleoplasm] (Rattus norvegicus)

rps-14 [nucleoplasm] (Caenorhabditis elegans)

rps1401 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001020241.1, NP_005608.1, NP_001020242.1

OpenTargets

ENSG00000164587

GeneCards

P62263

HPA

ENSG00000164587-RPS14

Ensembl

ENSP00000311028, ENSG00000164587, ENSP00000385425, ENST00000407193, ENST00000521466, ENSP00000428509, ENST00000312037, ENST00000401695, ENSP00000385958

PRO

P62263

Pharos - Targets

P62263

Orphanet

17749

PDB

7WTW, 8T4S, 6ZON, 6ZM7, 5FLX, 6Z6N, 5A2Q, 8GLP, 8PPL, 6ZLW, 6ZMW, 6Z6M, 6G18, 7A09, 8IFD, 8Y0W, 5T2C, 7WTU, 6OM7, 5VYC, 6G51, 6OLZ, 5AJ0, 8JDM, 8G5Y, 6G4S, 6ZMO, 7TQL, 4UG0, 6ZV6, 6Y0G, 6YBD, 7WTX, 6IP5, 6G5I, 6ZXH, 7R4X, 6OLG, 6XA1, 6ZUO, 7QP7, 8PPK, 7XNY, 6ZXF, 6ZXG, 4V6X, 6OLF, 7QP6, 6ZN5, 8OZ0, 6OLE, 8JDK, 6ZXE, 6ZOK, 7XNX, 8G6J, 7WTV, 6G53, 6Z6L, 6ZVH, 6G4W, 6ZXD, 8JDL, 5LKS, 6ZMT, 6ZOJ, 7K5I, 6FEC, 7WU0, 7WTZ, 6IP8, 6YBW, 7MQA, 8IFE, 6Y57, 8G60, 8G61, 8Y0X, 6ZMI, 5OA3, 6OM0, 6QZP, 7WTT, 6Y2L, 6ZP4, 6G5H, 6IP6, 6ZME, 7MQ9, 8JDJ, 6OLI, 7WTS, 7MQ8

Interactors (57)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13601 KRR1	1	KRR1 [nucleoplasm] (R-HSA-6790611)	0.742	6
UniProt:P61247 RPS3A	2	RPS3A [nucleoplasm] (R-HSA-6791182) RPS3A [cytosol] (R-HSA-72373)	0.669	4
UniProt:Q16594 TAF9	1	TAF9 [nucleoplasm] (R-HSA-212452)	0.667	4
UniProt:Q9Y3D8 AK6	1	AK6 [nucleoplasm] (R-HSA-6788786)	0.666	4
UniProt:Q2NL82 TSR1	2	TSR1 [nucleoplasm] (R-HSA-6791574) TSR1 [cytosol] (R-HSA-6791570)	0.643	3
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.615	3
UniProt:O00233 PSMD9	1	PSMD9 [cytosol] (R-HSA-68810)	0.611	3
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.597	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.569	6
UniProt:O15479 MAGB2			0.564	2
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.527	2
UniProt:P86790 CCZ1B	1	CCZ1B [cytosol] (R-HSA-8877440)	0.527	3
UniProt:Q9GZR2 REXO4			0.527	2
UniProt:Q9NVU7 SDA1			0.527	2
UniProt:P84098 RPL19	1	RPL19 [cytosol] (R-HSA-72424)	0.527	2
UniProt:Q8N9T8 KRI1			0.527	3
UniProt:Q68D10 SPT2			0.527	2
UniProt:Q9H8G1 ZNF430	1	ZNF430 [nucleoplasm] (R-HSA-1247517)	0.527	2
UniProt:Q96SB4 SRPK1	2	SRPK1 [nucleoplasm] (R-HSA-9821984) SRPK1 [cytosol] (R-HSA-9729349)	0.527	2
UniProt:P39019 RPS19	2	RPS19 [nucleoplasm] (R-HSA-6798710) RPS19 [cytosol] (R-HSA-72343)	0.527	2
UniProt:Q15050 RRS1			0.527	2
UniProt:P58317 ZN121			0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q03701 CEBPZ			0.527	2
UniProt:Q9H8H2 DDX31			0.527	2
UniProt:O43422 P52K			0.527	3
UniProt:Q9GZR7 DDX24			0.527	2
UniProt:Q9Y3T9 NOC2L	1	NOC2L [nucleoplasm] (R-HSA-3222129)	0.527	2
UniProt:Q9BVI4 NOC4L	1	NOC4L [nucleoplasm] (R-HSA-6790616)	0.527	2
UniProt:Q96MG8 PCMD1			0.527	2
UniProt:Q14692 BMS1	1	BMS1 [nucleoplasm] (R-HSA-6790720)	0.527	2
UniProt:P61313 RPL15	1	RPL15 [cytosol] (R-HSA-72416)	0.527	2
UniProt:Q9Y4C8 RBM19			0.527	2
UniProt:P62280 RPS11	2	RPS11 [nucleoplasm] (R-HSA-6791212) RPS11 [cytosol] (R-HSA-72327)	0.527	2
UniProt:P30414 NKTR			0.527	2
UniProt:Q96EM0 T3HPD			0.527	3
UniProt:Q9H0A0 NAT10	1	NAT10 [nucleoplasm] (R-HSA-6791008)	0.527	2
UniProt:Q5JTH9 RRP12			0.527	2
UniProt:P62277 RPS13	2	RPS13 [nucleoplasm] (R-HSA-6791198) RPS13 [cytosol] (R-HSA-72331)	0.527	2
UniProt:Q9H6S0 YTDC2			0.527	2
UniProt:P62910 RPL32	1	RPL32 [cytosol] (R-HSA-72456)	0.527	2
UniProt:Q15397 PUM3			0.527	2
UniProt:Q6PK04 CC137			0.527	2
UniProt:Q96JK2 DCAF5	1	DCAF5 [nucleoplasm] (R-HSA-8955189)	0.527	2
UniProt:Q9NVP1 DDX18			0.527	2
UniProt:O43167 ZBT24			0.527	2
UniProt:Q13523 PRPF4B	1	PRPF4B [nucleoplasm] (R-HSA-9769525)	0.527	2
UniProt:Q9NW13 RBM28	1	RBM28 [nucleoplasm] (R-HSA-6791192)	0.527	2
UniProt:Q9ULX3 NOB1	2	NOB1 [nucleoplasm] (R-HSA-6791536) NOB1 [cytosol] (R-HSA-6791524)	0.527	2
UniProt:Q9H5J8 TAF1D	1	TAF1D [nucleoplasm] (R-HSA-5138533)	0.527	2
UniProt:P62249 RPS16	2	RPS16 [nucleoplasm] (R-HSA-6791196) RPS16 [cytosol] (R-HSA-72337)	0.527	2
UniProt:Q96GA3 LTV1	2	LTV1 [nucleoplasm] (R-HSA-6791566) LTV1 [cytosol] (R-HSA-6791520)	0.527	3
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.527	2
UniProt:Q15361 TTF1	1	TTF1 [nucleoplasm] (R-HSA-74974)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12
UniProt:Q00005 2ABB			0.462	2

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