Reactome | FCF1 [nucleoplasm]

FCF1 [nucleoplasm]

Stable Identifier

R-HSA-6790672

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

rRNA-processing protein FCF1 homolog, FCF1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q8NEX9 SDR9C7

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External Reference Information

External Reference

UniProt:Q9Y324 FCF1

Gene Names

FCF1, C14orf111, CGI-35

Chain

chain:1-198

Reference Genes

BioGPS Gene:51077 FCF1

COSMIC (genes):FCF1 FCF1

CTD Gene:51077 FCF1

dbSNP Gene:51077 FCF1

ENSEMBL:ENSG00000119616 FCF1

ENSEMBL_homo_sapiens_GENE:ENSG00000119616.11 FCF1

HGNC:20220 FCF1

KEGG Gene (Homo sapiens):51077 FCF1

Monarch:51077 FCF1

NCBI Gene:51077 FCF1

UCSC:Q9Y324 FCF1

Reference Transcript

RefSeq:NM_015962.4 FCF1

Other Identifiers

11739430_x_at

11739431_x_at

11753299_a_at

11753300_x_at

11762067_at

11762068_x_at

16786475

212499_PM_s_at

212499_s_at

219927_PM_at

219927_at

240928_PM_at

240928_at

2769896

3544217

3544220

3544224

3544225

3544227

3544229

3544231

3544233

3544234

3544235

3544236

3544237

3544238

3544239

3544240

3544242

3544244

51077

78285_i_at

78288_f_at

7975713

84019_at

A_24_P56407

A_32_P202092

A_33_P3264505

GE58630

GO:0000447

GO:0000480

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0006364

GO:0032040

GO:0042254

GO:0042274

GO:0043226

HMNXSV003001537

HMNXSV003026824

Hs.162102.0.A1_3p_at

ILMN_2189869

ILMN_2189870

PH_hs_0016622

TC14000462.hg

g7705729_3p_s_at

Participates

as a component of

SSU Processome [nucleoplasm] (Homo sapiens)

This entity regulates

Positively

30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)

Inferred To

Bka [nucleoplasm] (Drosophila melanogaster)

Fcf1 [nucleoplasm] (Mus musculus)

Fcf1 [nucleoplasm] (Rattus norvegicus)

FCF1 [nucleoplasm] (Bos taurus)

FCF1 [nucleoplasm] (Caenorhabditis elegans)

FCF1 [nucleoplasm] (Canis familiaris)

FCF1 [nucleoplasm] (Gallus gallus)

FCF1 [nucleoplasm] (Plasmodium falciparum)

FCF1 [nucleoplasm] (Saccharomyces cerevisiae)

FCF1 [nucleoplasm] (Sus scrofa)

fcf1 [nucleoplasm] (Dictyostelium discoideum)

fcf1 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_057046.1

OpenTargets

ENSG00000119616

GeneCards

Q9Y324

HPA

ENSG00000119616-FCF1

Ensembl

ENST00000341162, ENSG00000119616, ENSP00000344393

PRO

Q9Y324

Pharos - Targets

Q9Y324

PDB

7MQ8, 7MQ9, 7MQA

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5MJ68 SPDYC			0.556	3
UniProt:Q9P287 BCCIP			0.556	3
UniProt:P47929 LGALS7	1	LGALS7 [cytosol] (R-HSA-9861116)	0.527	2
UniProt:O60437 PPL	2	PPL [cytosol] (R-HSA-6810850) PPL [cornified envelope] (R-HSA-8847709)	0.527	2
UniProt:P36952 SPB5			0.527	2
UniProt:P07476 IVL	2	IVL [cornified envelope] (R-HSA-8847720) IVL [cytosol] (R-HSA-6810837)	0.527	2
UniProt:P17931 LGALS3	3	LGALS3 [ficolin-1-rich granule membrane] (R-HSA-6803307) LGALS3 [plasma membrane] (R-HSA-879445) LGALS3 [secretory granule membrane] (R-HSA-6803327)	0.527	2
UniProt:P42357 HAL	1	HAL [cytosol] (R-HSA-70897)	0.527	2
UniProt:Q92817 EVPL	2	EVPL [cornified envelope] (R-HSA-8847741) EVPL [cytosol] (R-HSA-6810853)	0.527	2
UniProt:P20930 FLG	2	FLG(?-?) [cytosol] (R-HSA-6810859) FLG(1-4061) [cytosol] (R-HSA-8849818)	0.527	2
UniProt:O43240 KLK10			0.527	2
UniProt:Q53RT3 APRV1			0.527	2
UniProt:P61020 RAB5B	8	RAB5B [secretory granule membrane] (R-HSA-6804966) RAB5B [plasma membrane] (R-HSA-6804984) GGC-RAB5B [macropinosome membrane] (R-HSA-9837696) RAB5B [cytosol] (R-HSA-8870412) GGC-RAB5B [cytosol] (R-HSA-8870434) GGC-RAB5B [early endosome membrane] (R-HSA-8875327) RAB5B [early endosome membrane] (R-HSA-2029080) GGC-RAB5B [clathrin-coated endocytic vesicle membrane] (R-HSA-8871126)	0.527	2
UniProt:Q9NZT1 CALML5	3	CALML5 [cytosol] (R-HSA-9839523) CALML5 [extracellular region] (R-HSA-6806470) CALML5 [ficolin-1-rich granule lumen] (R-HSA-6801291)	0.527	2
UniProt:Q8NEX9 SDR9C7	1	SDR9C7 [endoplasmic reticulum membrane] (R-HSA-4084690)	0.527	2
UniProt:P05120 SERPINB2	2	SERPINB2 [plasma membrane] (R-HSA-159004) SERPINB2 [extracellular region] (R-HSA-158997)	0.527	2
UniProt:Q6UWP8 SBSN	1	SBSN [secretory granule lumen] (R-HSA-9839544)	0.527	2
UniProt:P50452 SERPINB8	1	SERPINB8 [plasma membrane] (R-HSA-2990856)	0.527	2
UniProt:Q9Y446 PKP3	2	PKP3 [cornified envelope] (R-HSA-8847728) PKP3 [plasma membrane] (R-HSA-6814399)	0.527	2
UniProt:Q8IW75 SPA12			0.527	2
UniProt:P02511 CRYAB	1	CRYAB [nucleoplasm] (R-HSA-6806336)	0.527	2
UniProt:Q6ZVX7 FBX50			0.527	2
UniProt:P31944 CASP14	2	CASP14(6-146) [cytosol] (R-HSA-8847667) CASP14(153-242) [cytosol] (R-HSA-8847687)	0.527	2
UniProt:P48163 ME1	2	p-S336-ME1 [cytosol] (R-HSA-9861606) ME1 [cytosol] (R-HSA-400119)	0.527	2
UniProt:Q5T749 KPRP	1	KPRP [cytosol] (R-HSA-9839614)	0.527	2
UniProt:P58107 EPIPL			0.527	2

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