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NOL11 [nucleoplasm]
Stable Identifier
R-HSA-6790684
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nucleolar protein 11, NOL11_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q13901 C1D
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)
NOL11 [nucleoplasm] (Homo sapiens)
47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA (Homo sapiens)
NOL11 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
22916032
NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing
Prieto, JL
,
McStay, B
,
Baserga, SJ
,
McCann, KL
,
Freed, EF
PLoS Genet.
2012
External Reference Information
External Reference
UniProt:Q9H8H0 NOL11
Gene Names
NOL11, L14
Chain
chain:1-719
Reference Genes
BioGPS Gene:25926 NOL11
COSMIC (genes):NOL11 NOL11
CTD Gene:25926 NOL11
dbSNP Gene:25926 NOL11
ENSEMBL:ENSG00000130935 NOL11
ENSEMBL_homo_sapiens_GENE:ENSG00000130935.10 NOL11
HGNC:24557 NOL11
KEGG Gene (Homo sapiens):25926 NOL11
Monarch:25926 NOL11
NCBI Gene:25926 NOL11
OMIM:615366 NOL11
UCSC:Q9H8H0 NOL11
Reference Transcript
RefSeq:NM_001303272.1 NOL11
RefSeq:NM_015462.4 NOL11
Other Identifiers
11722996_a_at
11722997_s_at
16837205
221970_PM_s_at
221970_s_at
25926
3732374
3732377
3732378
3732380
3732382
3732383
3732385
3732387
3732388
3732390
3732391
3732392
3732394
3732395
3732397
3732398
3732402
3732403
3732404
3732405
3732406
3732407
3732408
3732409
3732410
3994692
3994693
3994694
3994696
51140_at
8009366
A_23_P55073
GE56447
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0006351
GO:0006355
GO:0006364
GO:0030490
GO:0034455
GO:0042254
GO:0043226
GO:1901838
HMNXSV003024278
Hs.321105.0.S1_3p_s_at
ILMN_1688971
PH_hs_0002363
TC17000795.hg
Participates
as a component of
SSU Processome [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA
(Homo sapiens)
30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA
(Homo sapiens)
Inferred To
NOL11 [nucleoplasm]
(Bos taurus)
NOL11 [nucleoplasm]
(Canis familiaris)
NOL11 [nucleoplasm]
(Gallus gallus)
NOL11 [nucleoplasm]
(Sus scrofa)
Ghost homologue of NOL11 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of NOL11 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of NOL11 [nucleoplasm]
(Plasmodium falciparum)
Ghost homologue of NOL11 [nucleoplasm]
(Saccharomyces cerevisiae)
Ghost homologue of NOL11 [nucleoplasm]
(Schizosaccharomyces pombe)
Dmel\CG9300 [nucleoplasm]
(Drosophila melanogaster)
Nol11 [nucleoplasm]
(Mus musculus)
Nol11 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_001290201.1
,
NP_056277.2
OpenTargets
ENSG00000130935
GeneCards
Q9H8H0
HPA
ENSG00000130935-NOL11
Ensembl
ENSP00000463219
,
ENST00000253247
,
ENST00000581375
,
ENSG00000130935
,
ENSP00000253247
PRO
Q9H8H0
Pharos - Targets
Q9H8H0
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q969X6 UTP4
1
CIRH1A [nucleoplasm]
(R-HSA-6790662)
0.768
10
UniProt:P22087 FBL
1
FBL [nucleoplasm]
(R-HSA-6790638)
0.564
2
UniProt:Q9UMY1 UTP16
0.527
3
UniProt:Q13901 C1D
1
C1D [nucleoplasm]
(R-HSA-6791515)
0.527
2
UniProt:Q15061 WDR43
1
WDR43 [nucleoplasm]
(R-HSA-6790653)
0.527
2
UniProt:Q5FYB1 ARSI
2
OxA-ARSI [endoplasmic reticulum lumen]
(R-HSA-1614360)
ARSI [endoplasmic reticulum lumen]
(R-HSA-1609671)
0.527
2
UniProt:P32970 CD70
1
CD70 [plasma membrane]
(R-HSA-5667139)
0.527
3
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