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GAR1 [nucleoplasm]
Stable Identifier
R-HSA-6790707
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
H/ACA ribonucleoprotein complex subunit 1, GAR1_HUMAN
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere Extension By Telomerase (Homo sapiens)
Alignment Of The RNA Template On The Telomeric Chromosome End (Homo sapiens)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
GAR1 [nucleoplasm] (Homo sapiens)
Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
GAR1 [nucleoplasm] (Homo sapiens)
Biogenesis and assembly of the telomerase RNP (Homo sapiens)
GAR1 [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
GAR1 [nucleoplasm] (Homo sapiens)
Disassociation of Telomerase RNP and the Chromosome End (Homo sapiens)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
GAR1 [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
GAR1 [nucleoplasm] (Homo sapiens)
Elongation Of The Telomeric Chromosome End (Homo sapiens)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
GAR1 [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
GAR1 [nucleoplasm] (Homo sapiens)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
GAR1 [nucleoplasm] (Homo sapiens)
Elongation of Extended Telomeric Chromosome End (Homo sapiens)
Telomerase Holoenzyme Base-paired to the Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
GAR1 [nucleoplasm] (Homo sapiens)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
GAR1 [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
GAR1 [nucleoplasm] (Homo sapiens)
Recruitment of Telomerase RNP to the Telomeric Chromosome End (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
GAR1 [nucleoplasm] (Homo sapiens)
Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
GAR1 [nucleoplasm] (Homo sapiens)
Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Homo sapiens)
Telomerase Holoenzyme Base-paired to the Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
GAR1 [nucleoplasm] (Homo sapiens)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
GAR1 [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
rRNA modification in the nucleus and cytosol (Homo sapiens)
Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA (Homo sapiens)
Box H/ACA snoRNP [nucleoplasm] (Homo sapiens)
GAR1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NY12 GAR1
Gene Names
GAR1, NOLA1
Chain
chain:1-217
Reference Genes
BioGPS Gene:54433 GAR1
COSMIC (genes):GAR1 GAR1
CTD Gene:54433 GAR1
dbSNP Gene:54433 GAR1
ENSEMBL:ENSG00000109534 GAR1
ENSEMBL_homo_sapiens_GENE:ENSG00000109534.17 GAR1
HGNC:14264 GAR1
KEGG Gene (Homo sapiens):54433 GAR1
Monarch:54433 GAR1
NCBI Gene:54433 GAR1
OMIM:606468 GAR1
UCSC:Q9NY12 GAR1
Reference Transcript
RefSeq:NM_032993.2 GAR1
RefSeq:NM_018983.3 GAR1
Other Identifiers
11723483_at
11758592_s_at
16969700
219110_PM_at
219110_at
2739243
2739245
2739247
2739248
2739251
2739253
2739255
2739256
2739257
2739263
2739265
2739266
54433
62544_s_at
62546_at
8096821
A_23_P58280
GE55321
GO:0000454
GO:0000781
GO:0001522
GO:0001650
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005697
GO:0005730
GO:0006364
GO:0007004
GO:0015030
GO:0031429
GO:0032200
GO:0034513
GO:0042254
GO:0043226
GO:0070034
GO:0072589
GO:0090661
GO:1990904
HMNXSV003035017
ILMN_1749752
ILMN_2412549
TC04000565.hg
g9506712_3p_at
Participates
as a component of
Box H/ACA snoRNP [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
as an input of
Biogenesis and assembly of the telomerase RNP (Homo sapiens)
Inferred To
Gar1 [nucleoplasm]
(Mus musculus)
Gar1 [nucleoplasm]
(Rattus norvegicus)
gar1 [nucleoplasm]
(Dictyostelium discoideum)
gar1 [nucleoplasm]
(Schizosaccharomyces pombe)
GAR1 [nucleoplasm]
(Bos taurus)
GAR1 [nucleoplasm]
(Caenorhabditis elegans)
GAR1 [nucleoplasm]
(Drosophila melanogaster)
GAR1 [nucleoplasm]
(Gallus gallus)
GAR1 [nucleoplasm]
(Plasmodium falciparum)
GAR1 [nucleoplasm]
(Saccharomyces cerevisiae)
GAR1 [nucleoplasm]
(Sus scrofa)
Ghost homologue of GAR1 [nucleoplasm]
(Canis familiaris)
Cross References
RefSeq
NP_127460.1
,
NP_061856.1
OpenTargets
ENSG00000109534
HPA
ENSG00000109534-GAR1
GeneCards
Q9NY12
Ensembl
ENSP00000226796
,
ENST00000226796
,
ENSP00000378127
,
ENST00000394631
,
ENSG00000109534
PRO
Q9NY12
Pharos - Targets
Q9NY12
PDB
7BGB
,
7V9A
,
8OUF
,
8OUE
,
7TRC
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60832 DKC1
1
DKC1 [nucleoplasm]
(R-HSA-163102)
0.793
6
UniProt:Q9NPE3 NOP10
1
NOP10 [nucleoplasm]
(R-HSA-6790665)
0.643
5
UniProt:P54105 CLNS1A
1
CLNS1A [cytosol]
(R-HSA-191796)
0.643
4
UniProt:Q16637 SMN1
2
SMN1 [nucleoplasm]
(R-HSA-191892)
SMN1 [cytosol]
(R-HSA-191839)
0.544
2
UniProt:Q9BUR4 WRAP53
2
WRAP53 [nucleoplasm]
(R-HSA-418386)
Unfolded WRAP53 [cytosol]
(R-HSA-6813830)
0.527
3
UniProt:Q9BRS2 RIOK1
2
RIOK1 [nucleoplasm]
(R-HSA-5226890)
RIOK1 [cytosol]
(R-HSA-6791525)
0.527
3
UniProt:Q8TEQ6 GEMIN5
2
GEMIN5 [cytosol]
(R-HSA-191833)
GEMIN5 [nucleoplasm]
(R-HSA-191765)
0.527
3
UniProt:Q9Y4F1 FARP1
1
FARP1 [cytosol]
(R-HSA-9679578)
0.527
2
UniProt:Q9NQ92 COPRS
1
COPRS [nucleoplasm]
(R-HSA-5212681)
0.527
3
UniProt:O14744 PRMT5
3
p-Y297,304,307-PRMT5 [nucleoplasm]
(R-HSA-5211300)
PRMT5 [nucleoplasm]
(R-HSA-5205609)
PRMT5 [cytosol]
(R-HSA-191876)
0.527
3
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.527
2
UniProt:Q9BQA1 WDR77
3
WDR77 [nucleoplasm]
(R-HSA-5205610)
pT5-WDR77 [nucleoplasm]
(R-HSA-5205602)
WDR77 [cytosol]
(R-HSA-191823)
0.527
2
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