Reactome | NOP2 [nucleoplasm]

NOP2 [nucleoplasm]

Stable Identifier

R-HSA-6790922

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Probable 28S rRNA, NOP2_HUMAN

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External Reference Information

External Reference

UniProt:P46087 NOP2

Gene Names

NOP2, NOL1, NSUN1

Chain

chain:1-812

Reference Genes

BioGPS Gene:4839 NOP2

COSMIC (genes):NOP2 NOP2

CTD Gene:4839 NOP2

dbSNP Gene:4839 NOP2

ENSEMBL:ENSG00000111641 NOP2

ENSEMBL_homo_sapiens_GENE:ENSG00000111641.13 NOP2

HGNC:7867 NOP2

KEGG Gene (Homo sapiens):4839 NOP2

Monarch:4839 NOP2

NCBI Gene:4839 NOP2

OMIM:164031 NOP2

UCSC:P46087 NOP2

Reference Transcript

Other Identifiers

11736019_a_at

11737775_a_at

11756849_x_at

16760437

1979_s_at

214427_PM_at

214427_at

2674353

3442025

3442026

3442027

3442028

3442030

3442032

3442033

3442034

3442036

3442037

3442038

3442039

3442041

3442042

3442044

3442046

3442047

3442048

3442049

3442050

3442051

4839

7893289

7960575

A_23_P204364

GE57932

GO:0000027

GO:0000470

GO:0001510

GO:0003723

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0006364

GO:0006396

GO:0008168

GO:0008173

GO:0008284

GO:0008757

GO:0009383

GO:0016740

GO:0023052

GO:0032259

GO:0042254

GO:0043226

GO:0065003

GO:0070475

GO:0140098

GO:1901796

HMNXSV003052327

Hs.15243.0.S1_3p_at

ILMN_1666960

ILMN_1723158

ILMN_2328433

PH_hs_0001422

TC12001142.hg

Participates

as an output of

The NOP2 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer (Homo sapiens)

Cross References

RefSeq

XP_005253748.1, NP_001245238.1, NP_006161.2, NP_001028886.1, NP_001245237.1, NP_001245239.1

OpenTargets

ENSG00000111641

GeneCards

P46087

HPA

ENSG00000111641-NOP2

Ensembl

ENST00000545200, ENSP00000443150, ENSP00000313272, ENST00000382421, ENSP00000439422, ENST00000541778, ENST00000537442, ENST00000322166, ENSP00000444437, ENST00000399466, ENSG00000111641, ENSP00000382392, ENSP00000371858

PRO

P46087

Pharos - Targets

P46087

PDB

8FKT, 8FKV, 8FKX, 8FKU, 8FKW, 8FKY

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y221 NIP7	1	NIP7 [nucleoplasm] (R-HSA-6797236)	0.669	5
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.643	3
UniProt:Q9NW13 RBM28	1	RBM28 [nucleoplasm] (R-HSA-6791192)	0.564	3
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.556	3
UniProt:Q96GN5 CDA7L			0.556	3
UniProt:Q8N1B4 VPS52	1	VPS52 [trans-Golgi network membrane] (R-HSA-6811029)	0.556	3
UniProt:O60684 KPNA6	2	KPNA6 [nucleoplasm] (R-HSA-9734665) KPNA6 [cytosol] (R-HSA-9734672)	0.556	3
UniProt:P04733 MT1F	1	MT1F [cytosol] (R-HSA-5660426)	0.556	3
UniProt:P59923 ZNF445	1	ZNF445 [nucleoplasm] (R-HSA-1247874)	0.527	2
UniProt:Q9UPE1 SRPK3			0.527	2
UniProt:Q9UHB9 SRP68	1	SRP68 [cytosol] (R-HSA-445234)	0.527	2
UniProt:P46777 RPL5	1	RPL5 [cytosol] (R-HSA-72482)	0.527	3
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.527	2
UniProt:P62753 RPS6	4	RPS6 [nucleoplasm] (R-HSA-6790606) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) p-5S-RPS6 [cytosol] (R-HSA-165727) RPS6 [cytosol] (R-HSA-72381)	0.483	4
UniProt:Q8WYQ5 DGCR8	1	DGCR8 [nucleoplasm] (R-HSA-1482509)	0.483	2

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