Reactome | NOP2 [nucleoplasm]

NOP2 [nucleoplasm]

Stable Identifier

R-HSA-6790922

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Probable 28S rRNA, NOP2_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q9UHB9 SRP68

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External Reference Information

External Reference

UniProt:P46087 NOP2

Gene Names

NOP2, NOL1, NSUN1

Chain

chain:1-812

Reference Genes

BioGPS Gene:4839 NOP2

COSMIC (genes):NOP2 NOP2

CTD Gene:4839 NOP2

dbSNP Gene:4839 NOP2

ENSEMBL:ENSG00000111641 NOP2

HGNC:7867 NOP2

KEGG:hsa:4839 NOP2

Monarch:4839 NOP2

NCBI Gene:4839 NOP2

OMIM:164031 NOP2

UCSC:P46087 NOP2

Reference Transcript

Other Identifiers

11736019_a_at

11737775_a_at

11756849_x_at

16760437

1979_s_at

214427_PM_at

214427_at

2674353

3442023

3442025

3442026

3442027

3442028

3442029

3442030

3442031

3442032

3442033

3442034

3442035

3442036

3442037

3442038

3442039

3442040

3442041

3442042

3442043

3442044

3442045

3442046

3442047

3442048

3442049

3442050

3442051

4839

7893289

7960575

A_23_P204364

GE57932

GO:0000027

GO:0000470

GO:0001510

GO:0003723

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0006364

GO:0006396

GO:0008168

GO:0008173

GO:0008284

GO:0008757

GO:0009383

GO:0016740

GO:0032259

GO:0042254

GO:0042273

GO:0043226

GO:0065003

GO:0070475

GO:0140098

GO:1901796

HMNXSV003052327

Hs.15243.0.S1_3p_at

ILMN_1666960

ILMN_1723158

ILMN_2328433

PH_hs_0001422

TC12001142.hg

Participates

as an output of

The NOP2 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer (Homo sapiens)

Cross References

OpenTargets

ENSG00000111641

ENSEMBL

ENST00000545200, ENSP00000313272, ENST00000541778, ENSP00000444437, ENST00000537442, ENST00000382421, ENST00000322166, ENSP00000443150, ENSP00000439422, ENSP00000371858, ENSP00000382392, ENST00000399466

HPA

ENSG00000111641-NOP2

PRO

P46087

Pharos - Targets

P46087

GlyGen

P46087

PDB

8FKY, 8FKU, 8FKW, 8FKT, 8FKV, 8FKX

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y221 NIP7	1	NIP7 [nucleoplasm] (R-HSA-6797236)	0.669	5
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.643	3
UniProt:Q9NW13 RBM28	1	RBM28 [nucleoplasm] (R-HSA-6791192)	0.564	3
UniProt:P04733 MT1F	1	MT1F [cytosol] (R-HSA-5660426)	0.556	3
UniProt:O60684 KPNA6	2	KPNA6 [nucleoplasm] (R-HSA-9734665) KPNA6 [cytosol] (R-HSA-9734672)	0.556	3
UniProt:Q8N1B4 VPS52	1	VPS52 [trans-Golgi network membrane] (R-HSA-6811029)	0.556	3
UniProt:Q96GN5 CDA7L			0.556	3
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.556	3
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.527	2
UniProt:P46777 RPL5	1	RPL5 [cytosol] (R-HSA-72482)	0.527	3
UniProt:Q9UHB9 SRP68	1	SRP68 [cytosol] (R-HSA-445234)	0.527	2
UniProt:Q9UPE1 SRPK3			0.527	2
UniProt:P59923 ZNF445	1	ZNF445 [nucleoplasm] (R-HSA-1247874)	0.527	2
UniProt:Q8WYQ5 DGCR8	1	DGCR8 [nucleoplasm] (R-HSA-1482509)	0.483	2
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.483	4

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