Reactome | RPS3A [nucleoplasm]

RPS3A [nucleoplasm]

Stable Identifier

R-HSA-6791182

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

fullName evidence="2"40S ribosomal protein S3a, RS3A_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P61247 RPS3A

Gene Names

RPS3A, FTE1, MFTL

Chain

initiator methionine:, chain:2-264

Reference Genes

BioGPS Gene:6189 RPS3A

COSMIC (genes):RPS3A RPS3A

CTD Gene:6189 RPS3A

dbSNP Gene:6189 RPS3A

ENSEMBL:ENSG00000145425 RPS3A

ENSEMBL_homo_sapiens_GENE:ENSG00000145425.10 RPS3A

ENSEMBL_homo_sapiens_GENE:ENSG00000292158.1 RPS3A

HGNC:10421 RPS3A

KEGG Gene (Homo sapiens):6189 RPS3A

Monarch:6189 RPS3A

NCBI Gene:6189 RPS3A

OMIM:180478 RPS3A

UCSC:P61247 RPS3A

Reference Transcript

RefSeq:NM_001006.4 RPS3A

Other Identifiers

11716320_x_at

1653_at

16971413

18670014

18670019

18670020

18670021

18670022

18670023

18670025

18670027

18670028

18670029

18670030

200099_PM_s_at

200099_s_at

201257_PM_x_at

201257_x_at

212391_PM_x_at

212391_x_at

2612273

2640149

2683221

2747386

2747387

2747392

2747394

2747396

2747397

2747404

2747406

2864032

2870769

2870772

3061872

3062954

3062956

3062958

3062959

3062962

3062963

3084158

3084759

3122846

3124697

3124911

3255508

3255510

3255512

3259229

3359842

3379154

3482604

3596234

3596235

3596236

3621007

3621014

3790794

3790796

3957133

6189

7894205

7894971

7894982

7988031

8097782

8103222

8141050

8141222

A_23_P144497

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005783

GO:0005829

GO:0005840

GO:0005925

GO:0006412

GO:0006413

GO:0012501

GO:0022626

GO:0022627

GO:0030154

GO:0032040

GO:0042254

GO:0042274

GO:0043066

GO:0043226

GO:0045202

GO:0048027

GO:0070062

GO:1990904

HMNXSV003004860

HMNXSV003018368

Hs.77039.1.S1_3p_x_at

ILMN_1657722

ILMN_1673638

ILMN_2139943

M84711_at

PH_hs_0029871

g4506722_3p_x_at

Participates

as a component of

18SE pre-40S particle [nucleoplasm] (Homo sapiens)

This entity regulates

Positively

30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)

Other forms of this molecule

RPS3A [cytosol]

Inferred To

RPS3A [nucleoplasm] (Bos taurus)

RPS3A [nucleoplasm] (Canis familiaris)

RPS3A [nucleoplasm] (Plasmodium falciparum)

RPS3A [nucleoplasm] (Sus scrofa)

RpS3A [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of RPS3A [nucleoplasm] (Gallus gallus)

RPS1B [nucleoplasm] (Saccharomyces cerevisiae)

rps-1 [nucleoplasm] (Caenorhabditis elegans)

rps101 [nucleoplasm] (Schizosaccharomyces pombe)

Rps3a [nucleoplasm] (Mus musculus)

Rps3a [nucleoplasm] (Rattus norvegicus)

rps3a [nucleoplasm] (Danio rerio)

rps3a [nucleoplasm] (Dictyostelium discoideum)

rps3a [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_000997.1

OpenTargets

ENSG00000145425

HPA

ENSG00000145425-RPS3A

GeneCards

P61247

Ensembl

ENSP00000346050, ENSG00000145425, ENST00000274065

PRO

P61247

Pharos - Targets

P61247

PDB

6XA1, 6ZXD, 6Z6N, 6ZM7, 6IP6, 6IP5, 5LKS, 5T2C, 7WTZ, 6ZOJ, 6Y0G, 6G4S, 6OLI, 4V6X, 5VYC, 6G18, 7WU0, 6ZME, 7QP6, 6ZXF, 8PPL, 6G4W, 6ZUO, 7WTS, 6IP8, 6OLZ, 7A09, 6G53, 6ZXE, 6G51, 8PPK, 7MQ9, 5A2Q, 7MQ8, 6ZV6, 6OLE, 8IFE, 6ZXG, 7WTT, 8G6J, 7XNX, 8IFD, 6OM7, 6Y57, 6ZXH, 7XNY, 7WTW, 4UG0, 8G60, 6Z6L, 6ZMT, 7WTX, 8JDJ, 7QVP, 8JDK, 6G5H, 6FEC, 6OLG, 5OA3, 6Z6M, 6OLF, 6G5I, 6ZN5, 6ZOK, 8JDL, 8JDM, 8T4S, 6ZVJ, 6ZMW, 6ZVH, 7K5I, 8G61, 5FLX, 8GLP, 6YBD, 6OM0, 6ZON, 6Y2L, 7WTV, 7TQL, 6QZP, 7WTU, 8OZ0, 5AJ0, 6ZP4, 8Y0X, 8Y0W, 7QP7, 6ZMI, 6YBW, 8G5Z, 7MQA, 8G5Y, 7R4X, 6ZLW, 6ZMO

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62263 RPS14	2	RPS14 [nucleoplasm] (R-HSA-6790669) RPS14 [cytosol] (R-HSA-72333)	0.669	4
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.635	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.569	9
UniProt:P62906 RPL10A	1	RPL10A [cytosol] (R-HSA-72404)	0.564	2
UniProt:Q9NX58 LYAR			0.564	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:P16104 H2AFX	7	Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583)	0.527	2
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.527	2
UniProt:P42696 RBM34			0.527	2
UniProt:Q9NZM5 NOP53			0.527	2
UniProt:P62280 RPS11	2	RPS11 [nucleoplasm] (R-HSA-6791212) RPS11 [cytosol] (R-HSA-72327)	0.527	2
UniProt:P62241 RPS8	2	RPS8 [nucleoplasm] (R-HSA-6791203) RPS8 [cytosol] (R-HSA-72385)	0.527	3
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.527	4
UniProt:P15880 RPS2	3	RPS2 [nucleoplasm] (R-HSA-6790655) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [cytosol] (R-HSA-72347)	0.527	3
UniProt:Q15050 RRS1			0.527	2
UniProt:Q15397 PUM3			0.527	2
UniProt:P17026 ZNF22			0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.527	3
UniProt:O95793 STAU1			0.527	2
UniProt:Q1ED39 KNOP1			0.527	2
UniProt:P10412 H1-4	1	HIST1H1E [nucleoplasm] (R-HSA-211251)	0.527	2
UniProt:Q96ME7 ZN512			0.527	2
UniProt:Q96HE9 PRR11			0.527	2
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.495	2
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.483	2
UniProt:P62753 RPS6	4	RPS6 [nucleoplasm] (R-HSA-6790606) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) p-5S-RPS6 [cytosol] (R-HSA-165727) RPS6 [cytosol] (R-HSA-72381)	0.483	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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