Reactome | SKIV2L2 [nucleoplasm]

SKIV2L2 [nucleoplasm]

Stable Identifier

R-HSA-6791189

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Superkiller viralicidic activity 2-like 2 ecNumber3.6.4.13/ecNumber, SK2L2_HUMAN, MTREX, MTR4

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P42285 MTREX

Gene Names

MTREX, DOB1, KIAA0052, MTR4, SKIV2L2

Chain

initiator methionine:1, chain:2-1042

Reference Genes

BioGPS Gene:23517 MTREX

COSMIC (genes):MTREX MTREX

CTD Gene:23517 MTREX

dbSNP Gene:23517 MTREX

ENSEMBL:ENSG00000039123.16 MTREX

HGNC:18734 MTREX

KEGG Gene (Homo sapiens):23517 MTREX

Monarch:23517 MTREX

NCBI Gene:23517 MTREX

OMIM:618122 MTREX

UCSC:P42285 MTREX

Reference Transcript

RefSeq:NM_015360.4 MTREX

Other Identifiers

11720465_a_at

11758835_at

16984829

212896_PM_at

212896_at

227447_PM_at

227447_at

23517

2809887

2809893

2809895

2809896

2809897

2809898

2809899

2809900

2809901

2809902

2809903

2809904

2809905

2809906

2809907

2809916

2809917

2809919

2809923

2809924

2809926

2809930

2809932

2809938

2809940

2809942

2809944

2809951

2809955

2809956

2809957

2809958

41557_at

8105353

A_14_P100709

A_14_P103213

A_14_P139060

A_23_P110661

D29641_at

GE61016

GO:0000166

GO:0000176

GO:0000178

GO:0000398

GO:0000460

GO:0003676

GO:0003723

GO:0003724

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005681

GO:0005730

GO:0006364

GO:0006397

GO:0006401

GO:0006974

GO:0008380

GO:0016071

GO:0016073

GO:0016076

GO:0016607

GO:0016787

GO:0016887

GO:0031499

GO:0042254

GO:0043226

GO:0071013

GO:0140098

GO:0140657

HMNXSV003040130

Hs.278608.0.S1_3p_at

Hs.41569.2.S1_3p_at

ILMN_1651513

PH_hs_0014173

TC05000234.hg

TC05002382.hg

Participates

as a component of

as an input of

Formation of the Spliceosomal Pre-B complex (Homo sapiens)

as an output of

Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)

This entity regulates

Positively

Inferred To

SKIV2L2 [nucleoplasm] (Caenorhabditis elegans)

SKIV2L2 [nucleoplasm] (Canis familiaris)

SKIV2L2 [nucleoplasm] (Danio rerio)

SKIV2L2 [nucleoplasm] (Dictyostelium discoideum)

SKIV2L2 [nucleoplasm] (Gallus gallus)

SKIV2L2 [nucleoplasm] (Mus musculus)

SKIV2L2 [nucleoplasm] (Plasmodium falciparum)

SKIV2L2 [nucleoplasm] (Saccharomyces cerevisiae)

SKIV2L2 [nucleoplasm] (Schizosaccharomyces pombe)

mtrex [nucleoplasm] (Xenopus tropicalis)

MTREX [nucleoplasm] (Bos taurus)

MTREX [nucleoplasm] (Sus scrofa)

Mtr4 [nucleoplasm] (Drosophila melanogaster)

Mtrex [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_056175.3

OpenTargets

ENSG00000039123

GeneCards

P42285

HPA

ENSG00000039123-MTREX

Ensembl

ENSP00000230640, ENSG00000039123, ENST00000230640

PRO

P42285

Pharos - Targets

P42285

HMDB Protein

HMDBP11958

PDB

7S7C, 6IEH, 7Z4Y, 6D6Q, 6C90, 7S7B, 6D6R, 7Z52, 6RO1, 7Z4Z, 6IEG

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q66LE6 PPP2R2D	1	PPP2R2D [nucleoplasm] (R-HSA-2160962)	0.671	4
UniProt:Q99547 MPHOSPH6	1	MPHOSPH6 [nucleoplasm] (R-HSA-6791553)	0.592	2
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.569	3
UniProt:Q9NQT5 EXOSC3	2	EXOSC3 [nucleoplasm] (R-HSA-6791572) EXOSC3 [cytosol] (R-HSA-430017)	0.527	2
UniProt:P52298 NCBP2	2	NCBP2 [nucleoplasm] (R-HSA-51463) NCBP2 [cytosol] (R-HSA-162458)	0.527	4
UniProt:Q9Y580 RBM7	1	RBM7 [nucleoplasm] (R-HSA-8985564)	0.527	2
UniProt:Q9NQT4 EXOSC5	2	EXOSC5 [cytosol] (R-HSA-429889) EXOSC5 [nucleoplasm] (R-HSA-6791550)	0.527	2
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	6
UniProt:Q00005 2ABB			0.462	2

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