Reactome | RPS13 [nucleoplasm]

RPS13 [nucleoplasm]

Stable Identifier

R-HSA-6791198

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

40S ribosomal protein S13, RS13_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9UHB9 SRP68

Expand all

External Reference Information

External Reference

UniProt:P62277 RPS13

Gene Names

RPS13

Chain

initiator methionine:, chain:2-151

Reference Genes

BioGPS Gene:6207 RPS13

COSMIC (genes):RPS13 RPS13

CTD Gene:6207 RPS13

dbSNP Gene:6207 RPS13

ENSEMBL:ENSG00000110700 RPS13

HGNC:10386 RPS13

KEGG:hsa:6207 RPS13

Monarch:6207 RPS13

NCBI Gene:6207 RPS13

OMIM:180476 RPS13

UCSC:P62277 RPS13

Reference Transcript

RefSeq:NM_001017.2 RPS13

Other Identifiers

11756060_s_at

16654055

16654057

16654059

16654061

16654063

16654065

16654067

16736211

16736224

17118820

18671365

18671366

18671367

18671368

18671369

18671370

18671371

18671372

18671373

18671374

18671375

18671376

200018_PM_at

200018_at

2413009

2413011

33619_at

3364723

3364724

3364725

3364726

3364727

3364728

3364729

3364730

3364731

3364732

3364733

3364734

3364735

3364736

3364737

3364738

3364739

3364740

3364741

3364743

3364745

3364747

3364749

3364751

3364753

3364755

6207

7892520

7893298

7893573

7893850

7894106

7894254

7894916

7895392

7895780

7895936

7895972

7896363

7896368

7896446

7946812

ADDON000110.hg

A_21_P0014671

A_23_P24763

A_24_P372608

A_32_P86028

GE61226

GO:0002181

GO:0003723

GO:0003729

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0005840

GO:0005925

GO:0006396

GO:0006412

GO:0014069

GO:0016020

GO:0022626

GO:0022627

GO:0032040

GO:0033119

GO:0042274

GO:0043226

GO:0048027

GO:0070062

GO:0070181

GO:1990904

HMNXSV003027517

ILMN_1707598

ILMN_1777344

ILMN_1799381

PH_hs_0030325

TC11001453.hg

TC11001454.hg

TC11003072.hg

TC11003475.hg

g4506684_3p_at

g4506684_3p_s_at

Participates

as a component of

18SE pre-40S particle [nucleoplasm] (Homo sapiens)

This entity regulates

Positively

30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)

Other forms of this molecule

RPS13 [cytosol]

Inferred To

rps13 [nucleoplasm] (Danio rerio)

rps13 [nucleoplasm] (Dictyostelium discoideum)

rps13 [nucleoplasm] (Schizosaccharomyces pombe)

Ghost homologue of RPS13 [nucleoplasm] (Xenopus tropicalis)

rps-13 [nucleoplasm] (Caenorhabditis elegans)

Rps13 [nucleoplasm] (Mus musculus)

Rps13 [nucleoplasm] (Rattus norvegicus)

RpS13 [nucleoplasm] (Drosophila melanogaster)

RPS13 [nucleoplasm] (Bos taurus)

RPS13 [nucleoplasm] (Canis familiaris)

RPS13 [nucleoplasm] (Gallus gallus)

RPS13 [nucleoplasm] (Plasmodium falciparum)

RPS13 [nucleoplasm] (Saccharomyces cerevisiae)

RPS13 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001008.1

OpenTargets

ENSG00000110700

ENSEMBL

ENSP00000435777, ENST00000525634

HPA

ENSG00000110700-RPS13

PRO

P62277

Pharos - Targets

P62277

GlyGen

P62277

PDB

5FLX, 6ZON, 8XXM, 6Y2L, 6ZXD, 6OLF, 6ZUO, 6ZXF, 7QP6, 6G5H, 8JDK, 8G60, 8G5Z, 6ZLW, 7WTT, 8QOI, 6ZMT, 6Z6M, 8IFE, 6ZV6, 6ZMW, 6QZP, 6G53, 6G4S, 6OM0, 6FEC, 6Y57, 6OLE, 7MQ9, 7JQB, 7TQL, 7MQ8, 8GLP, 6ZXH, 6ZMO, 7QP7, 6IP6, 8G61, 8JDL, 8Y0X, 8PPL, 7WTV, 7WTU, 6Z6L, 6ZN5, 7WTX, 5T2C, 6ZVH, 6G4W, 7K5I, 8G6J, 8XXL, 6ZM7, 7A09, 6ZP4, 5A2Q, 4V6X, 6ZME, 7JQC, 6ZXG, 5OA3, 8G5Y, 6IP5, 8JDM, 6YBD, 8XXN, 6YBW, 6OM7, 6ZMI, 6G18, 7XNX, 6Z6N, 7MQA, 8IFD, 7R4X, 4UG0, 8OZ0, 6XA1, 7WU0, 6OLG, 6ZXE, 7WTS, 5AJ0, 8PPK, 6G5I, 8JDJ, 8Y0W, 6OLI, 6ZOK, 6IP8, 5LKS, 8T4S, 7WTW, 7XNY, 7WTZ, 6ZOJ, 6ZVJ, 6Y0G, 6G51, 5VYC, 6OLZ

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	19
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.59	3
UniProt:Q99558 MAP3K14	5	Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.564	3
UniProt:P62241 RPS8	2	RPS8 [cytosol] (R-HSA-72385) RPS8 [nucleoplasm] (R-HSA-6791203)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	6
UniProt:P62249 RPS16	2	RPS16 [cytosol] (R-HSA-72337) RPS16 [nucleoplasm] (R-HSA-6791196)	0.527	2
UniProt:Q13601 KRR1	1	KRR1 [nucleoplasm] (R-HSA-6790611)	0.527	3
UniProt:Q96HE9 PRR11			0.527	2
UniProt:Q9UN86 G3BP2	1	G3BP2 [cytosol] (R-HSA-9729507)	0.527	2
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.527	2
UniProt:Q53EL6 PDCD4	1	PDCD4 [cytosol] (R-HSA-5432887)	0.527	2
UniProt:Q15050 RRS1			0.527	2
UniProt:P39019 RPS19	2	RPS19 [cytosol] (R-HSA-72343) RPS19 [nucleoplasm] (R-HSA-6798710)	0.527	3
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	4
UniProt:Q9UHB9 SRP68	1	SRP68 [cytosol] (R-HSA-445234)	0.527	2
UniProt:P62263 RPS14	2	RPS14 [cytosol] (R-HSA-72333) RPS14 [nucleoplasm] (R-HSA-6790669)	0.527	2
UniProt:Q2NL82 TSR1	2	TSR1 [nucleoplasm] (R-HSA-6791574) TSR1 [cytosol] (R-HSA-6791570)	0.527	2
UniProt:P42696 RBM34			0.527	2
UniProt:P62888 RPL30	1	RPL30 [cytosol] (R-HSA-72452)	0.527	3
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	3
UniProt:Q8NAV1 PRPF38A	1	PRPF38A [nucleoplasm] (R-HSA-8867897)	0.508	2
UniProt:Q8WYQ5 DGCR8	1	DGCR8 [nucleoplasm] (R-HSA-1482509)	0.483	2
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.483	2
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.483	2
UniProt:Q92731 ESR2	5	ESR2 [cytosol] (R-HSA-9020970) ESR2 [nucleoplasm] (R-HSA-446165) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979)	0.462	2

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