Reactome | RPS28 [nucleoplasm]

RPS28 [nucleoplasm]

Stable Identifier

R-HSA-6791202

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

40S ribosomal protein S28, RS28_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P62857 RPS28

Gene Names

RPS28

Chain

chain:1-69

Reference Genes

BioGPS Gene:6234 RPS28

COSMIC (genes):RPS28 RPS28

CTD Gene:6234 RPS28

dbSNP Gene:6234 RPS28

ENSEMBL:ENSG00000233927 RPS28

HGNC:10418 RPS28

KEGG:hsa:6234 RPS28

Monarch:6234 RPS28

NCBI Gene:6234 RPS28

OMIM:603685 RPS28

UCSC:P62857 RPS28

Reference Transcript

RefSeq:NM_001031.4 RPS28

Other Identifiers

11742666_s_at

11742667_x_at

11757387_x_at

11759537_a_at

11759538_at

11761031_x_at

11763284_a_at

16729548

16857878

208902_PM_s_at

208902_s_at

208903_PM_at

208903_at

208904_PM_s_at

208904_s_at

2531815

2531816

2531817

3342374

3342375

3342376

3342377

3713452

3713453

3819460

3819461

3819462

3819463

3819464

3819465

3819466

3819467

39798_at

48357_at

6234

7942824

8005471

8025395

A_14_P135680

A_24_P40010

A_33_P3282836

GE54648

GE85004

GO:0000028

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005783

GO:0005791

GO:0005829

GO:0005840

GO:0006364

GO:0006412

GO:0015935

GO:0022627

GO:0030490

GO:0032040

GO:0042254

GO:0042274

GO:0043226

GO:0045202

GO:0065003

GO:0070062

GO:0098556

GO:1990904

HMNXSV003031681

Hs.153177.1.A2_3p_at

ILMN_1651228

ILMN_1684258

PH_hs_0031869

TC19000146.hg

U58682_at

g12653172_3p_a_at

Participates

as a component of

18SE pre-40S particle [nucleoplasm] (Homo sapiens)

This entity regulates

Positively

30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)

Other forms of this molecule

RPS28 [cytosol]

Inferred To

RPS28 [nucleoplasm] (Bos taurus)

RPS28 [nucleoplasm] (Canis familiaris)

RPS28 [nucleoplasm] (Gallus gallus)

RPS28 [nucleoplasm] (Plasmodium falciparum)

RPS28 [nucleoplasm] (Sus scrofa)

RpS28b [nucleoplasm] (Drosophila melanogaster)

rps-28 [nucleoplasm] (Caenorhabditis elegans)

RPS28B [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of RPS28 [nucleoplasm] (Schizosaccharomyces pombe)

rps2801 [nucleoplasm] (Schizosaccharomyces pombe)

rps2802 [nucleoplasm] (Schizosaccharomyces pombe)

Rps28 [nucleoplasm] (Mus musculus)

Rps28 [nucleoplasm] (Rattus norvegicus)

rps28 [nucleoplasm] (Danio rerio)

rps28 [nucleoplasm] (Dictyostelium discoideum)

rps28 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001022.1

OpenTargets

ENSG00000233927

ENSEMBL

ENSP00000472469, ENST00000600659

HPA

ENSG00000233927-RPS28

PRO

P62857

Pharos - Targets

P62857

Orphanet

RPS28

GlyGen

P62857

PDB

6IP5, 7QP7, 4V6X, 8G5Y, 6ZOJ, 6ZVJ, 6Y0G, 7XNY, 6G51, 6OLZ, 7WTZ, 8T4S, 5LKS, 7WTW, 5VYC, 7R4X, 5OA3, 6ZXG, 7MQ9, 8XXN, 7A09, 6ZP4, 6FEC, 5A2Q, 8JDM, 8XXL, 6IP6, 6OLE, 8JDL, 8G61, 6ZMO, 7QP6, 7MQA, 8IFD, 6Z6N, 6ZMI, 7XNX, 4UG0, 6G18, 6OM7, 7K5I, 6ZXH, 5T2C, 7TQL, 7MQ8, 8GLP, 6Y57, 6ZLW, 6Y2L, 8Y0X, 6OM0, 8PPL, 6OLF, 6G4W, 6ZVH, 6Z6L, 6ZN5, 7WTX, 7WTV, 8G6J, 7WTU, 6QZP, 6ZUO, 6ZXF, 8XXM, 6G5H, 8G5Z, 5FLX, 6ZXD, 8JDK, 8G60, 6YBS, 8OZ0, 6ZON, 7WU0, 6IP8, 8Y0W, 6ZOL, 8JDJ, 8PPK, 6G4S, 6Z6M, 6ZMT, 6ZMW, 6G53, 8IFE, 6ZV6, 7WTT, 8QOI, 6OLI, 6ZME, 5AJ0, 6G5I, 6OLG, 6XA1, 6ZM7, 6ZXE

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.715	4
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:P0C7H8 KRTAP2-3	1	KRTAP2-3 [cytosol] (R-HSA-6809959)	0.556	3
UniProt:Q07627 KRTAP1-1	1	KRTAP1-1 [cytosol] (R-HSA-6809855)	0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:O95273 CCDB1			0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:O75031 HSF2B			0.556	3
UniProt:P26583 HMGB2	1	HMGB2 [nucleoplasm] (R-HSA-266211)	0.547	2
UniProt:P62280 RPS11	2	RPS11 [cytosol] (R-HSA-72327) RPS11 [nucleoplasm] (R-HSA-6791212)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.527	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.527	2
UniProt:P84098 RPL19	1	RPL19 [cytosol] (R-HSA-72424)	0.527	2
UniProt:Q15050 RRS1			0.527	2
UniProt:Q15599 NHRF2			0.508	2

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