Reactome | RPS8 [nucleoplasm]

RPS8 [nucleoplasm]

Stable Identifier

R-HSA-6791203

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

40S ribosomal protein S8, RS8_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O60832 DKC1

Expand all

External Reference Information

External Reference

UniProt:P62241 RPS8

Gene Names

RPS8, OK/SW-cl.83

Chain

initiator methionine:, chain:2-208

Reference Genes

BioGPS Gene:6202 RPS8

COSMIC (genes):RPS8 RPS8

CTD Gene:6202 RPS8

dbSNP Gene:6202 RPS8

ENSEMBL:ENSG00000142937 RPS8

ENSEMBL_homo_sapiens_GENE:ENSG00000142937.12 RPS8

HGNC:10441 RPS8

KEGG Gene (Homo sapiens):6202 RPS8

Monarch:6202 RPS8

NCBI Gene:6202 RPS8

OMIM:600357 RPS8

Reference Transcript

RefSeq:NM_001012.1 RPS8

Other Identifiers

11715543_x_at

16663989

200858_PM_s_at

200858_s_at

2334165

2334166

2334170

2334174

2334175

2334176

2334179

2334180

2334184

2334189

2334190

2805737

2805739

2805742

31583_at

3203916

3203922

3582023

3613011

3613012

6202

74705_s_at

7901038

A_23_P46182

GO:0000462

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005783

GO:0005829

GO:0005840

GO:0005925

GO:0006412

GO:0016020

GO:0022626

GO:0022627

GO:0032040

GO:0042254

GO:0042274

GO:0043226

GO:0070062

GO:1990904

HMNXSV003008668

PH_hs_0034351

X67247_rna1_at

g4506742_3p_s_at

Participates

as a component of

18SE pre-40S particle [nucleoplasm] (Homo sapiens)

This entity regulates

Positively

30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)

Other forms of this molecule

RPS8 [cytosol]

Inferred To

RPS8A [nucleoplasm] (Saccharomyces cerevisiae)

Rps8 [nucleoplasm] (Mus musculus)

Rps8 [nucleoplasm] (Rattus norvegicus)

rps8 [nucleoplasm] (Dictyostelium discoideum)

rps8 [nucleoplasm] (Xenopus tropicalis)

RPS8 [nucleoplasm] (Bos taurus)

RPS8 [nucleoplasm] (Canis familiaris)

RPS8 [nucleoplasm] (Gallus gallus)

RPS8 [nucleoplasm] (Plasmodium falciparum)

RPS8 [nucleoplasm] (Sus scrofa)

rps-8 [nucleoplasm] (Caenorhabditis elegans)

rps8b [nucleoplasm] (Danio rerio)

RpS8 [nucleoplasm] (Drosophila melanogaster)

Homologues of RPS8 [nucleoplasm] (Saccharomyces cerevisiae)

RPS8B [nucleoplasm] (Saccharomyces cerevisiae)

rps802 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001003.1

OpenTargets

ENSG00000142937

HPA

ENSG00000142937-RPS8

GeneCards

P62241

Ensembl

ENSG00000142937, ENST00000396651, ENSP00000379888

PRO

P62241

Pharos - Targets

P62241

PDB

6ZMT, 7WTU, 8IFE, 7MQ9, 8G61, 6Z6M, 6ZVH, 5AJ0, 6ZMW, 8Y0W, 6ZOJ, 7WTT, 6Z6N, 7WTW, 7QVP, 6OLG, 6IP5, 6ZON, 6OLI, 6IP6, 5OA3, 6G18, 6ZVJ, 7MQA, 7WTV, 6ZOK, 8G5Y, 6G4S, 6Y2L, 6IP8, 6G51, 6ZP4, 6ZMI, 6G4W, 7K5I, 4V6X, 5VYC, 6QZP, 8JDJ, 6ZMO, 7WTS, 6G53, 8G60, 7QP7, 6OM0, 6OLZ, 8GLP, 5A2Q, 5FLX, 8OZ0, 7R4X, 6ZLW, 6OLE, 7TQL, 6ZM7, 8JDL, 6OLF, 4UG0, 6FEC, 6XA1, 6G5H, 6ZN5, 6G5I, 7XNX, 6Y0G, 6ZME, 8Y0X, 6ZXD, 8JDM, 6ZXE, 5LKS, 5T2C, 8T4S, 7XNY, 6YBW, 8PPK, 7WTX, 6ZUO, 7A09, 6ZXF, 8G5Z, 7QP6, 8IFD, 6ZXG, 7MQ8, 8PPL, 7WU0, 8G6J, 6Y57, 6OM7, 6Z6L, 8JDK, 6ZV6, 6ZXH, 7WTZ

Interactors (77)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P84098 RPL19	1	RPL19 [cytosol] (R-HSA-72424)	0.643	3
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.643	4
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:P62280 RPS11	2	RPS11 [nucleoplasm] (R-HSA-6791212) RPS11 [cytosol] (R-HSA-72327)	0.564	2
UniProt:Q15700 DLG2	2	DLG2 [plasma membrane] (R-HSA-9610662) DLG2 [cytosol] (R-HSA-6794230)	0.556	3
UniProt:Q92796 DLG3	2	DLG3 [plasma membrane] (R-HSA-443609) DLG3 [cytosol] (R-HSA-6794232)	0.556	3
UniProt:Q8IUE6 H2AC21	11	AcK-HIST2H2AB [nucleoplasm] (R-HSA-4551335) HIST2H2AB [nucleoplasm] (R-HSA-4549212) MeR12-HIST2H2AB [nucleoplasm] (R-HSA-5229207) Me2aR12-HIST2H2AB [nucleoplasm] (R-HSA-5229314) MeR4-HIST2H2AB [nucleoplasm] (R-HSA-5244632) Me2aR4-HIST2H2AB [nucleoplasm] (R-HSA-5244588) MeR30-HIST2H2AB [nucleoplasm] (R-HSA-5244540) Me2aR30-HIST2H2AB [nucleoplasm] (R-HSA-5244567) AcK6-HIST2H2AB [nucleoplasm] (R-HSA-4568609) Ub-HIST2H2AB [nucleoplasm] (R-HSA-6782490) K63polyUb-HIST2H2AB [nucleoplasm] (R-HSA-6783295)	0.527	2
UniProt:Q6NSZ9 ZSCAN25	1	ZSCAN25 [nucleoplasm] (R-HSA-1247859)	0.527	2
UniProt:P13693 TCTP			0.527	2
UniProt:P82675 MRPS5	1	MRPS5 [mitochondrial inner membrane] (R-HSA-5368176)	0.527	3
UniProt:Q14197 MRPL58	2	ICT1 [mitochondrial matrix] (R-HSA-5368175) ICT1 [mitochondrial inner membrane] (R-HSA-5624366)	0.527	3
UniProt:Q8TAE8 GADD45GIP1	1	GADD45GIP1 [mitochondrial matrix] (R-HSA-5368253)	0.527	3
UniProt:P42696 RBM34			0.527	2
UniProt:P51608 MECP2			0.527	3
UniProt:P50914 RPL14	1	RPL14 [cytosol] (R-HSA-72414)	0.527	2
UniProt:P26373 RPL13	1	RPL13 [cytosol] (R-HSA-72410)	0.527	2
UniProt:Q7Z7H8 MRPL10	1	MRPL10 [mitochondrial inner membrane] (R-HSA-5368182)	0.527	2
UniProt:P49406 MRPL19	1	MRPL19 [mitochondrial inner membrane] (R-HSA-5368215)	0.527	3
UniProt:Q9H0U6 MRPL18	1	MRPL18 [mitochondrial inner membrane] (R-HSA-5368207)	0.527	3
UniProt:Q99848 EBNA1BP2	1	EBNA1BP2 [nucleoplasm] (R-HSA-8869325)	0.527	2
UniProt:P39019 RPS19	2	RPS19 [nucleoplasm] (R-HSA-6798710) RPS19 [cytosol] (R-HSA-72343)	0.527	3
UniProt:P09001 MRPL3	1	MRPL3 [mitochondrial inner membrane] (R-HSA-5368242)	0.527	2
UniProt:Q15050 RRS1			0.527	3
UniProt:Q5T653 MRPL2	1	MRPL2 [mitochondrial inner membrane] (R-HSA-5368170)	0.527	3
UniProt:Q9BYC8 MRPL32	2	MRPL32 [mitochondrial matrix] (R-HSA-9839664) MRPL32 [mitochondrial inner membrane] (R-HSA-5368195)	0.527	3
UniProt:Q1ED39 KNOP1			0.527	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	4
UniProt:Q9P0M9 MRPL27	1	MRPL27 [mitochondrial inner membrane] (R-HSA-5368189)	0.527	2
UniProt:Q9H9J2 MRPL44	1	MRPL44 [mitochondrial inner membrane] (R-HSA-5368245)	0.527	3
UniProt:Q96A35 MRPL24	1	MRPL24 [mitochondrial inner membrane] (R-HSA-5368177)	0.527	3
UniProt:Q4G0J3 LARP7			0.527	2
UniProt:Q9Y2R9 MRPS7	1	MRPS7 [mitochondrial inner membrane] (R-HSA-5368191)	0.527	2
UniProt:Q9UN86 G3BP2	1	G3BP2 [cytosol] (R-HSA-9729507)	0.527	2
UniProt:Q96DV4 MRPL38	1	MRPL38 [mitochondrial inner membrane] (R-HSA-5368202)	0.527	3
UniProt:Q66K89 E4F1			0.527	2
UniProt:Q9NP92 MRPS30	1	MRPS30 [mitochondrial inner membrane] (R-HSA-5368258)	0.527	3
UniProt:Q9BQC6 MRPL57	1	MRPL57 [mitochondrial inner membrane] (R-HSA-8866678)	0.527	2
UniProt:P62888 RPL30	1	RPL30 [cytosol] (R-HSA-72452)	0.527	2
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.527	3
UniProt:Q9BYD6 MRPL1	1	MRPL1 [mitochondrial inner membrane] (R-HSA-5368196)	0.527	3
UniProt:Q13084 MRPL28	1	MRPL28 [mitochondrial inner membrane] (R-HSA-5368246)	0.527	3
UniProt:Q9Y4C8 RBM19			0.527	2
UniProt:Q15020 SART3			0.527	3
UniProt:Q13283 G3BP1	1	G3BP1 [cytosol] (R-HSA-9729517)	0.527	2
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.527	2
UniProt:Q9NX20 MRPL16	1	MRPL16 [mitochondrial inner membrane] (R-HSA-5368216)	0.527	3
UniProt:Q9NWU5 MRPL22	1	MRPL22 [mitochondrial inner membrane] (R-HSA-5368209)	0.527	3
UniProt:Q8TEX9 IPO4			0.527	3
UniProt:Q9H0A0 NAT10	1	NAT10 [nucleoplasm] (R-HSA-6791008)	0.527	2
UniProt:Q9P015 MRPL15	1	MRPL15 [mitochondrial inner membrane] (R-HSA-5368193)	0.527	3
UniProt:P82933 MRPS9	1	MRPS9 [mitochondrial inner membrane] (R-HSA-5368194)	0.527	3
UniProt:Q14684 RRP1B			0.527	2
UniProt:Q9BYD1 MRPL13	1	MRPL13 [mitochondrial inner membrane] (R-HSA-5368244)	0.527	3
UniProt:Q8IWX8 CHERP	1	CHERP [nucleoplasm] (R-HSA-8865901)	0.527	2
UniProt:P62277 RPS13	2	RPS13 [nucleoplasm] (R-HSA-6791198) RPS13 [cytosol] (R-HSA-72331)	0.527	2
UniProt:Q15397 PUM3			0.527	3
UniProt:O95793 STAU1			0.527	2
UniProt:Q5C9Z4 NOM1			0.527	2
UniProt:Q9NQ50 MRPL40	1	MRPL40 [mitochondrial inner membrane] (R-HSA-5368222)	0.527	3
UniProt:Q9NRX2 MRPL17	1	MRPL17 [mitochondrial inner membrane] (R-HSA-5368217)	0.527	2
UniProt:Q13405 MRPL49	1	MRPL49 [mitochondrial inner membrane] (R-HSA-5368260)	0.527	3
UniProt:Q4U2R6 MRPL51	1	MRPL51 [mitochondrial inner membrane] (R-HSA-5368168)	0.527	3
UniProt:O75607 NPM3			0.527	2
UniProt:P49711 CTCF	1	CTCF [nucleoplasm] (R-HSA-3782562)	0.527	2
UniProt:O43167 ZBT24			0.527	2
UniProt:Q2NL82 TSR1	2	TSR1 [nucleoplasm] (R-HSA-6791574) TSR1 [cytosol] (R-HSA-6791570)	0.527	2
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-81) [cytosol] (R-HSA-6782654) NEDD8(1-81) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.527	2
UniProt:O60832 DKC1	1	DKC1 [nucleoplasm] (R-HSA-163102)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P62249 RPS16	2	RPS16 [nucleoplasm] (R-HSA-6791196) RPS16 [cytosol] (R-HSA-72337)	0.527	2
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.527	2
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.527	2
UniProt:P61247 RPS3A	2	RPS3A [nucleoplasm] (R-HSA-6791182) RPS3A [cytosol] (R-HSA-72373)	0.527	3
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12
UniProt:P62753 RPS6	4	RPS6 [nucleoplasm] (R-HSA-6790606) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) p-5S-RPS6 [cytosol] (R-HSA-165727) RPS6 [cytosol] (R-HSA-72381)	0.483	2
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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