Reactome | NCL [nucleoplasm]

NCL [nucleoplasm]

Stable Identifier

R-HSA-6791213

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Nucleolin, NUCL_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q99608 NDN

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External Reference Information

External Reference

UniProt:P19338 NCL

Gene Names

NCL

Chain

initiator methionine:, chain:2-710

Reference Genes

BioGPS Gene:4691 NCL

COSMIC (genes):NCL NCL

CTD Gene:4691 NCL

dbSNP Gene:4691 NCL

ENSEMBL:ENSG00000115053 NCL

HGNC:7667 NCL

Monarch:4691 NCL

NCBI Gene:4691 NCL

OMIM:164035 NCL

UCSC:P19338 NCL

Reference Transcript

RefSeq:NM_005381.2 NCL

Other Identifiers

11745154_a_at

11745155_s_at

11763921_at

16909491

16909520

16909522

200610_PM_s_at

200610_s_at

241892_PM_at

241892_at

2603459

2603461

2603462

2603463

2603464

2603465

2603466

2603467

2603468

2603469

2603470

2603471

2603472

2603473

2603474

2603475

2603476

2603477

2603478

2603479

2603480

2603481

2603483

2603485

2603486

2603487

2603488

2603489

2603490

2603491

2603492

2603493

2603494

2603495

2603496

2603497

2603498

2603503

2603504

2603505

2603506

32590_at

4691

8059689

8059708

8059710

A_21_P0000293

A_21_P0000303

A_23_P5551

GE81501

GO:0001525

GO:0001533

GO:0003676

GO:0003677

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005694

GO:0005730

GO:0005737

GO:0005886

GO:0005938

GO:0006355

GO:0016020

GO:0017148

GO:0036464

GO:0042162

GO:0042731

GO:0042802

GO:0043226

GO:0043560

GO:0044547

GO:0045944

GO:0046627

GO:0048026

GO:0048027

GO:0050730

GO:0070062

GO:0071364

GO:0160056

GO:1901838

GO:1990830

GO:1990904

HMNXSV003009139

HMNXSV003016846

HMNXSV003041434

Hs.253767.0.A1_3p_at

ILMN_1695422

ILMN_2121437

M60858_rna1_at

PH_hs_0004572

RNA33455|snoRNA_scaRNA_51_137

RNA33661|snoRNA_scaRNA_257_80

TC02002859.hg

TC02002860.hg

TC02002861.hg

g4885510_3p_a_at

This entity regulates

Positively

47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA (Homo sapiens)

Other forms of this molecule

NCL [plasma membrane]

NCL [macropinosome membrane]

Inferred To

NCL [nucleoplasm] (Bos taurus)

NCL [nucleoplasm] (Canis familiaris)

NCL [nucleoplasm] (Dictyostelium discoideum)

NCL [nucleoplasm] (Gallus gallus)

NCL [nucleoplasm] (Sus scrofa)

Ncl [nucleoplasm] (Mus musculus)

Ncl [nucleoplasm] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000115053

ENSEMBL

ENST00000322723, ENSP00000318195

HPA

ENSG00000115053-NCL

PRO

P19338

Pharos - Targets

P19338

GlyGen

P19338

PDB

2FC8, 2FC9, 2KRR

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P39060-PRO_0000005794 COL18A1			0.784	12
ChEBI:28304 HEPARIN			0.722	3
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.71	8
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.643	5
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.643	4
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.615	3
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.59	3
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.59	2
UniProt:O95793 STAU1			0.577	3
UniProt:P16401 H1-5	1	HIST1H1B [nucleoplasm] (R-HSA-211248)	0.564	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.558	2
UniProt:P19338 NCL	3	NCL [plasma membrane] (R-HSA-9836466) NCL [macropinosome membrane] (R-HSA-9837666) NCL [nucleoplasm] (R-HSA-6791213)	0.558	5
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.547	2
UniProt:Q99608 NDN	1	NDN [nucleoplasm] (R-HSA-6789966)	0.536	2
UniProt:O75940 SMNDC1	1	SMNDC1 [nucleoplasm] (R-HSA-8865958)	0.536	2
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.527	2
UniProt:Q4G0J3 LARP7			0.527	2
UniProt:Q15050 RRS1			0.527	2
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.527	2
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.527	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:Q9CR42 ANKR1			0.524	2
UniProt:Q14684-1 RRP1B			0.512	4
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.499	3
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.499	3
IntAct:EBI-1549314 PROBE			0.499	2
IntAct:EBI-1549316 PROBE			0.499	2
UniProt:Q9Y6D6 BIG1			0.499	5
UniProt:Q8AZK7 EBNA5			0.499	2
UniProt:Q9UQ80 PA2G4	2	PA2G4 [extracellular region] (R-HSA-6806200) PA2G4 [azurophil granule lumen] (R-HSA-6799205)	0.499	2
UniProt:P62280 RPS11	2	RPS11 [cytosol] (R-HSA-72327) RPS11 [nucleoplasm] (R-HSA-6791212)	0.483	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	10
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.483	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.483	2
UniProt:Q01130 SRSF2	1	SRSF2 [nucleoplasm] (R-HSA-72033)	0.463	2
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.463	3
UniProt:P61586 RHOA	6	RHOA [plasma membrane] (R-HSA-194510) RHOA [cell junction] (R-HSA-2134503) RHOA [cytosol] (R-HSA-194866) RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082)	0.463	3
UniProt:P27958-PRO_0000037577			0.463	4
UniProt:P62140 PPP1CB	4	PPP1CB [cytosol] (R-HSA-163405) PPP1CB P49R [cytosol] (R-HSA-9660547) PPP1CB A56P [cytosol] (R-HSA-9660543) PPP1CB [nucleoplasm] (R-HSA-62003)	0.463	2
UniProt:Q8N0X7 SPART			0.462	2
IntAct:EBI-5333170 SSRNA			0.462	3
IntAct:EBI-5333168 SSRNA			0.462	4
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2
IntAct:EBI-5333262 SSDNA			0.462	4

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