Reactome | WDR12 [nucleoplasm]

WDR12 [nucleoplasm]

Stable Identifier

R-HSA-6791215

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

fullName evidence="1"Ribosome biogenesis protein WDR12, WDR12_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9GZL7 WDR12

Gene Names

WDR12

Chain

initiator methionine:, chain:2-423

Reference Genes

BioGPS Gene:55759 WDR12

COSMIC (genes):WDR12 WDR12

CTD Gene:55759 WDR12

dbSNP Gene:55759 WDR12

ENSEMBL:ENSG00000138442 WDR12

ENSEMBL_homo_sapiens_GENE:ENSG00000138442.11 WDR12

HGNC:14098 WDR12

KEGG Gene (Homo sapiens):55759 WDR12

Monarch:55759 WDR12

NCBI Gene:55759 WDR12

OMIM:616620 WDR12

UCSC:Q9GZL7 WDR12

Reference Transcript

RefSeq:NM_018256.3 WDR12

Other Identifiers

11744275_a_at

11746789_x_at

11760594_at

16907458

218512_PM_at

218512_at

238826_3p_x_at

238826_PM_x_at

238826_x_at

241687_PM_at

241687_at

2595432

2595433

2595434

2595435

2595436

2595437

2595438

2595440

2595442

2595444

2595445

2595446

2595447

2595448

2595449

2595450

2595451

2595452

2595454

2595455

2595457

2595459

2595460

2595463

2595464

2595465

2595466

2595467

2595468

2595469

2595470

2595471

46401_i_at

46402_r_at

55759

62554_at

71122_at

8058373

81158_r_at

A_23_P28625

A_32_P155563

GE55897

GE833775

GO:0000463

GO:0000466

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0006364

GO:0007219

GO:0023052

GO:0030687

GO:0042254

GO:0042273

GO:0043021

GO:0043226

GO:0051726

GO:0070545

HMNXSV003004262

Hs.155775.0.A1_3p_at

Hs.42612.0.A1_3p_at

Hs.42612.0.A1_3p_x_at

ILMN_1770692

ILMN_2045729

PH_hs_0004205

PH_hs_0008687

TC02002684.hg

g8922736_3p_at

Participates

as a component of

PeBoW complex [nucleoplasm] (Homo sapiens)

Inferred To

WDR12 [nucleoplasm] (Bos taurus)

WDR12 [nucleoplasm] (Canis familiaris)

WDR12 [nucleoplasm] (Drosophila melanogaster)

WDR12 [nucleoplasm] (Gallus gallus)

WDR12 [nucleoplasm] (Sus scrofa)

wdr12 [nucleoplasm] (Danio rerio)

wdr12 [nucleoplasm] (Dictyostelium discoideum)

wdr12 [nucleoplasm] (Xenopus tropicalis)

YTM1 [nucleoplasm] (Saccharomyces cerevisiae)

wdr-12 [nucleoplasm] (Caenorhabditis elegans)

Wdr12 [nucleoplasm] (Mus musculus)

Wdr12 [nucleoplasm] (Rattus norvegicus)

ytm1 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_060726.3

OpenTargets

ENSG00000138442

HPA

ENSG00000138442-WDR12

GeneCards

Q9GZL7

Ensembl

ENST00000688520, ENST00000261015, ENSP00000509107, ENSP00000261015, ENSG00000138442

PRO

Q9GZL7

Pharos - Targets

Q9GZL7

PDB

6N31, 6P0Q, 8FKY

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.615	3
UniProt:Q14137 BOP1	1	BOP1 [nucleoplasm] (R-HSA-6791206)	0.597	4
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.527	2

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