Reactome | 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA

12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA

Stable Identifier

R-HSA-6791218

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

ReviewStatus

5/5

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12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA

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The 12S pre-rRNA is nucleolytically cleaved to yield 5.8S rRNA. C1D, MPHOSPH6 (MPP6), and EXOSC10 (Pm/Scl-100) of the exosome associate and, together with SKIV2L2 (MTR4), are required for 3' processing of mature 5.8S rRNA therefore the exonuclease activity of the exosome seems to be involved (Schilders et al. 2007). Similarly, the DIS3 subunit of the nuclear exosome is required for production of 5.8S rRNA (Tomecki et al. 2010) and the 3'-5' exoribonuclease ISG20L2 (Coute et al. 2008) are also required for production of 5.8S rRNA from 12S pre-rRNA. As inferred from the mouse homolog, the 3'-5' exonuclease ERI1 also plays a role in trimming the 3' end of pre-5.8S rRNA (Ansel et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
20531386	The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L Pastula, A, Kristiansen, MS, Dziembowski, A, Larsen, KM, Andersen, JS, Tomecki, R, Jensen, TH, Chlebowski, A, Stepien, PP, Szczesny, RJ, Drazkowska, K, Lykke-Andersen, S	EMBO J.	2010
18438418	Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing Rao, A, Heissmeyer, V, Pastor, WA, Ansel, KM, Smith, LC, Glasmacher, E, Kremmer, E, Lamperti, ED, Ellwart, JW, Papadopoulou, N, Wolf, C, Rath, N, Shi, Y, Tahiliani, M, Lapan, AD	Nat. Struct. Mol. Biol.	2008
17412707	C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing Schilders, G, van Dijk, E, Pruijn, GJ	Nucleic Acids Res.	2007
18065403	ISG20L2, a novel vertebrate nucleolar exoribonuclease involved in ribosome biogenesis Sanchez, JC, Duret, L, Belin, S, Bezin, L, Diaz, JJ, Dieckmann, R, Couté, Y, Kindbeiter, K	Mol. Cell Proteomics	2008