GADD45A binds AURKA

Stable Identifier
R-HSA-6791235
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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GADD45A binds Aurora-A protein kinase (AURKA). GADD45A inhibits the kinase activity of AURKA and AURKA-induced centrosome amplification, thus interfering with the G2/M transition (Shao et al. 2006, Sanchez et al. 2010).
Literature References
PubMed ID Title Journal Year
20460379 Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase

Prieto, J, Marcaida, MJ, Montoya, G, Campos-Olivas, R, Blanco, FJ, Sánchez, R, Pantoja-Uceda, D, Diercks, T

J. Biol. Chem. 2010
16772293 Gadd45a interacts with aurora-A and inhibits its kinase activity

Zhao, Z, Dong, L, Wang, Y, Shao, S, Jin, S, Fu, M, Fan, F, Xu, N, Song, Y, Zhan, Q, Fan, W, Wang, X, Tong, T

J. Biol. Chem. 2006
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