Reactome | TP53 binds the BCL2L14 gene

TP53 binds the BCL2L14 gene

Stable Identifier

R-HSA-6791327

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
        
        TP53 binds the BCL2L14 gene (Homo sapiens)

General

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TP53 (p53) binds the p53 response element in the first intron of the BCL2L14 (BCLG) gene. Another p53 response element is found in the promoter region of the BCL2L14 gene but seems to interact with TP53 with low affinity (Miled et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15958553	A genomic map of p53 binding sites identifies novel p53 targets involved in an apoptotic network Garbay, S, Miled, C, Weitzman, JB, Yaniv, M, Pontoglio, M	Cancer Res.	2005

Participants

Input

Output

p-S15,S20-TP53 Tetramer:BCL2L14 Gene [nucleoplasm] (Homo sapiens)

Participates

as an event of

TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-08-20)

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